Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL–induced retinal pigment epithelial cell death as a potential pharmacotherapy

Autor: Franco Aparecido Rossato, Eun Young Choi, Andrew J. Urquhart, David A. Scott, Yin Shan E. Ng, Gopalan Gnanaguru, Ashley Mackey, Anthoula Arta, Patricia A. D'Amore, Thomas W. Gero

Publikováno v: Free Radic Biol Med

Late-stage dry age-related macular degeneration (AMD) or geographic atrophy (GA) is an irreversible blinding condition characterized by degeneration of retinal pigment epithelium (RPE) and the associated photoreceptors. Clinical and genetic evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691e14ee0f6eb5eaca0221237af4d0e9
https://doi.org/10.1016/j.freeradbiomed.2021.11.026

Cytotoxicity of the coagulant Moringa oleifera lectin (cMoL) to B16-F10 melanoma cells

Autor: Thiago Henrique Napoleão, Rute Alves Pereira e Costa, Patrícia Maria Guedes Paiva, Luciana A. Luz, Franco Aparecido Rossato, Luana Cassandra Breitenbach Barroso Coelho

Publikováno v: Toxicology in Vitro. 44:94-99

Moringa oleifera seeds are used in alternative medicine to treat inflammation, tumors and bacterial and protozoan infections, for example. The seeds contain lectins, which are carbohydrate-binding proteins with several biological properties including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cde64030e96a1656e6e95219da8c12b
https://doi.org/10.1016/j.tiv.2017.06.019

Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth

Autor: Felipe Osório-Costa, Marília M. Dias, Anibal E. Vercesi, Mario J.A. Saad, Eduardo R. Ropelle, José B.C. Carvalheira, Franco Aparecido Rossato, Guilherme Z. Rocha

Publikováno v: Clinical Cancer Research. 17:3993-4005

Purpose: Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by the activation of AMP-activated protein kinase (AMPK) and reduction of mTOR signaling, have become noteworthy. Chemotherapy produces genotoxic stress and indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95788e2c51ca710321436745b4e7a26
https://doi.org/10.1158/1078-0432.ccr-10-2243

Endocytosis of tight junctions caveolin nitrosylation dependent is improved by cocoa via opioid receptor on RPE cells in diabetic conditions

Autor: Mariana Aparecida Brunini Rosales, Diego Andreazzi Duarte, Franco Aparecido Rossato, José B. Lopes de Faria, Jacqueline M. Lopes de Faria, Kamila C. Silva

Publikováno v: Investigative ophthalmologyvisual science. 55(9)

PURPOSE Retinal pigment epithelium cells, along with tight junction (TJ) proteins, constitute the outer blood retinal barrier (BRB). Contradictory findings suggest a role for the outer BRB in the pathogenesis of diabetic retinopathy (DR). The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd9f053d1c8750e52998f9cbdd4a654
https://pubmed.ncbi.nlm.nih.gov/25190662

Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration

Autor: Franco Aparecido Rossato, Roger F. Castilho, Luciane C. Alberici, Rose Mara Ortega, Paolo G. La Guardia, Rodrigo Ramos Catharino, Anibal E. Vercesi, Rute Alves Pereira e Costa, Edgard Graner, Karina G. Zecchin

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e101060 (2014)
PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0652824fcef0e51351d946686db9ac6a
http://europepmc.org/articles/PMC4071076?pdf=render