Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Franco A Laimo"'
Autor:
Robert B Shultz, Kritika S Katiyar, Franco A Laimo, Justin C Burrell, Kevin D Browne, Zarina S Ali, Daniel K Cullen
Publikováno v:
Journal of Tissue Engineering, Vol 12 (2021)
Tissue engineered nerve grafts (TENGs) built from living neurons and aligned axon tracts offer a revolutionary new approach as “living scaffolds” to bridge major peripheral nerve defects. Clinical application, however, necessitates sufficient she
Externí odkaz:
https://doaj.org/article/d8746a4133624040a6146f1113537dc1
Autor:
Justin C. Burrell, Suradip Das, Franco A. Laimo, Kritika S. Katiyar, Kevin D. Browne, Robert B. Shultz, Vishal J. Tien, Phuong T. Vu, Dmitriy Petrov, Zarina S. Ali, Joseph M. Rosen, D. Kacy Cullen
Publikováno v:
Bioactive Materials, Vol 18, Iss , Pp 339-353 (2022)
Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle. While surgeons can re-route local axon fascicles t
Externí odkaz:
https://doaj.org/article/c77db7d415d3482bb7754e248e0058d9
Autor:
Kritika S. Katiyar, Laura A. Struzyna, Joseph P. Morand, Justin C. Burrell, Basak Clements, Franco A. Laimo, Kevin D. Browne, Joachim Kohn, Zarina Ali, Harry C. Ledebur, Douglas H. Smith, D. Kacy Cullen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects. We are advancing tissue engineered nerve grafts (TENGs) comprised o
Externí odkaz:
https://doaj.org/article/94c3a84b7693496cbc16aa2aa5b2c7a6
Autor:
Douglas H. Smith, Justin C. Burrell, Kevin D. Browne, Kritika S. Katiyar, Mindy I. Ezra, John L. Dutton, Joseph P. Morand, Laura A. Struzyna, Franco A. Laimo, H. Isaac Chen, John A. Wolf, Hilton M. Kaplan, Joseph M. Rosen, Harry C. Ledebur, Eric L. Zager, Zarina S. Ali, D. Kacy Cullen
Publikováno v:
Science Advances. 8
Functional restoration following major peripheral nerve injury (PNI) is challenging, given slow axon growth rates and eventual regenerative pathway degradation in the absence of axons. We are developing tissue-engineered nerve grafts (TENGs) to simul
Autor:
Dmitriy Petrov, Justin C. Burrell, Kevin D. Browne, Franco A. Laimo, Sanford E. Roberts, Zarina S. Ali, D. Kacy Cullen
Publikováno v:
Frontiers in Surgery. 9
Facial nerve trauma often leads to disfiguring facial muscle paralysis. Despite several promising advancements, facial nerve repair procedures often do not lead to complete functional recovery. Development of novel repair strategies requires testing
Autor:
D. Kacy Cullen, Halimulati Kaisaier, Zarina S. Ali, Kevin D. Browne, Foteini Mourkioti, Melanie C Hilman, Franco A Laimo, Carlos A. Aguilar, Suradip Das, Joseph C. Maggiore
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Communications Biology
Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle beyond the inherent regenerative capacity of the body, generally leading to severe functional deficit. Formation of appropriate somato-motor innervations remains one of
Autor:
Justin C. Burrell, John A. Wolf, Douglas H. Smith, Daniel P. Brown, Harry C. Ledebur, Dmitriy Petrov, Zarina S. Ali, Suradip Das, Kevin D. Browne, Hilton M. Kaplan, Franco A Laimo, John L. Dutton, Sanford E. Roberts, D. Kacy Cullen, H. Isaac Chen, Joseph M. Rosen
Publikováno v:
Neurosurgery. 87:833-846
Approximately 20 million Americans currently experience residual deficits from traumatic peripheral nerve injury. Despite recent advancements in surgical technique, peripheral nerve repair typically results in poor functional outcomes due to prolonge
Autor:
Justin C. Burrell, Suradip Das, Franco A. Laimo, Kritika S. Katiyar, Kevin D. Browne, Robert B. Shultz, Vishal J. Tien, Phuong T. Vu, Dmitriy Petrov, Zarina S. Ali, Joseph M. Rosen, D. Kacy Cullen
Publikováno v:
Bioactive materials. 18
Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle. While surgeons can re-route local axon fascicles t
Autor:
John Bianchi, Zarina S. Ali, Douglas H. Smith, Justin C. Burrell, David Ayares, Kevin D. Browne, Harry C. Ledebur, Franco A Laimo, D. Kacy Cullen, Anneke Walters, Kritika S. Katiyar
Publikováno v:
Tissue Eng Part A
Existing strategies for repair of major peripheral nerve injury (PNI) are inefficient at promoting axon regeneration and functional recovery and are generally ineffective for nerve lesions >5 cm. To address this need, we have previously developed tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f59877d06bb5f80732ed356c046fbb
https://europepmc.org/articles/PMC8610031/
https://europepmc.org/articles/PMC8610031/
Autor:
Divya Bhatnagar, John L. Dutton, Kevin D. Browne, N. Sanjeeva Murthy, Daniel P. Brown, Zarina S. Ali, Justin C. Burrell, Joseph M. Rosen, Joachim Kohn, D. Kacy Cullen, Hilton M. Kaplan, Franco A Laimo
Publikováno v:
Journal of biomedical materials research. Part AREFERENCES. 109(7)
Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies have shown tyrosine-derived polycarbonates (TyrPC) are versatile biomaterials with a wide ran