Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

Autor: Marion David, Chantal Lebrun, Thomas Duguet, Franck Talmont, Robin Beech, Stéphane Orlowski, François André, Roger K. Prichard, Anne Lespine

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 145-157 (2018)

Haemonchus contortus, one of the most economically important parasites of small ruminants, has become resistant to the anthelmintic ivermectin. Deciphering the role of P-glycoproteins in ivermectin resistance is desirable for understanding and overco

Externí odkaz: https://doaj.org/article/8c003bc3fbe248e0b8a0a3cf2f63c38a

Denatured G-protein coupled receptors as immunogens to generate highly specific antibodies.

Autor: Franck Talmont, Lionel Moulédous, Jérôme Boué, Catherine Mollereau, Gilles Dietrich

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46348 (2012)

G-protein coupled receptors (GPCRs) play a major role in a number of physiological and pathological processes. Thus, GPCRs have become the most frequent targets for development of new therapeutic drugs. In this context, the availability of highly spe

Externí odkaz: https://doaj.org/article/9ea70d9f8c434eaa98ce31cfaae5a116

Sphingosine kinase-1 is overexpressed and correlates with hypoxia in osteosarcoma: relationship with clinicopathological parameters

Autor: Anne Gomez-Brouchet, Claire Illac, Adeline Ledoux, Pierre-Yves Fortin, Sandra de Barros, Clémentine Vabre, Fabien Despas, Sophie Peries, Christelle Casaroli, Corinne Bouvier, Sébastien Aubert, Gonzague de Pinieux, Frédérique Larousserie, Louise Galmiche, Franck Talmont, Stuart Pitson, Marie-Lise Maddelein, Olivier Cuvillier

Publikováno v: Cancers; Volume 14; Issue 3; Pages: 499
Cancers, Vol 14, Iss 499, p 499 (2022)

The Sphingosine kinase-1/Sphingosine 1-Phosphate (SphK1/S1P) signaling pathway is overexpressed in various cancers, and is instrumental for the adaptation to hypoxia in a number of solid tumor models, but no data are available in osteosarcoma. Here w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b399a9bb5bdb0c14a183fc846a780c
https://hdl.handle.net/11541.2/27082

Pharmacological insight into the activation of the human Neuropeptide FF2 receptor

Autor: Catherine Mollereau, Franck Talmont, Remi Veneziano, Jean-Marie Zajac, Lionel Moulédous, Gilles Dietrich

Publikováno v: Peptides
Peptides, Elsevier, In press, pp.170406. ⟨10.1016/j.peptides.2020.170406⟩
Peptides, Elsevier, In press, 134, pp.170406. ⟨10.1016/j.peptides.2020.170406⟩

International audience; The neuropeptide FF2 (NPFF 2) receptor, predominantly expressed in the central nervous system, plays an important role in the modulation of sensory input and opioid analgesia, as well as in locomotion, feeding, intestinal moti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20310ea234c1be9a39fea73f928e72ae
https://hal.archives-ouvertes.fr/hal-02983059

Multiple sclerosis and modulators of sphingosine 1-phosphate receptors

Autor: Olivier Cuvillier, Anastassia Hatzoglou, Franck Talmont

Publikováno v: médecine/sciences
médecine/sciences, EDP Sciences, 2020, 36 (3), pp.243-252. ⟨10.1051/medsci/2020026⟩

Multiple sclerosis (MS) is a disease of the central nervous system with a very debilitating inflammatory component that usually affects young people (years 20-40). This disease is characterized by the progressive destruction of the myelin sheath of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88a54b3d99de9087b78a5ac73b74f22
https://hal.archives-ouvertes.fr/hal-02903955/file/msc190224.pdf