Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Franck Raeppel"'
SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes
Autor:
Stephen William Claridge, Daniel Delorme, Ljubomir Isakovic, David B. Llewellyn, Franck Raeppel, A. Robert MacLeod, Jeffrey M. Besterman, Amal Wahhab, Norman Beaulieu, Arkadii Vaisburg, Lijie Zhan, Jubrail Rahil, Oscar Mario Saavedra, Nadine Elowe, Naomy Bernstein, Andrea J. Petschner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2747-2751
The inhibitory activity of base-modified SAH analogues and the specificity of inhibiting human DNMT1 and DNMT3b2 enzymes was explored. The 6-amino group was essential while the 7-N of the adenine ring of SAH could be replaced by CH- without loss of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33ea1411905c14a49c5e81eae5869a9
https://doi.org/10.1016/j.bmcl.2009.03.113
https://doi.org/10.1016/j.bmcl.2009.03.113
Autor:
Annie Barsalou, Normand Beaulieu, Marja Dubay, Naomy Bernstein, Jeff Gillespie, Marie-France Robert, Jubrail Rahil, Isabelle Dupont, Ian Chute, Sylvain Lefebvre, Marie-Claude Granger, Hannah Nguyen, Oscar Mario Saavedra, James Wang, Jeffrey M. Besterman, Serge Gravel, Amal Wahhab, Lijie Zhan, Arkadii Vaisburg, Roussen Pascal, Carole Beaulieu, Zhiyun Jin, Franck Raeppel, Robert Deziel, David B. Llewellyn, A. Robert MacLeod, Stephen William Claridge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2793-2798
A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c793d69f791b3bd653b579bbb81a8c8
https://doi.org/10.1016/j.bmcl.2008.04.009
https://doi.org/10.1016/j.bmcl.2008.04.009
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(18)
New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49e322b9bebf56cc8599ca78978d007
https://pubmed.ncbi.nlm.nih.gov/26243370
https://pubmed.ncbi.nlm.nih.gov/26243370
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(17)
New fused bicyclic lactam head groups as rigidified analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Depending on the functionalities and the size of these bicyclic head groups, potent inhibitors of RON
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b162ba35d62dd4d77f4289de0539e6fa
https://pubmed.ncbi.nlm.nih.gov/26112445
https://pubmed.ncbi.nlm.nih.gov/26112445
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(12)
New carboxamide head group analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent and selective inhibitors of RON enzyme versus c-Met RTK were obtained.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ff7b2356b84773df4d340caf0e3b39
https://pubmed.ncbi.nlm.nih.gov/25953155
https://pubmed.ncbi.nlm.nih.gov/25953155
Publikováno v:
Tetrahedron Letters. 40:6377-6381
The perhydrobenz[ e ]indene moiety of the stellettins and of the stelliferins, two families of isomalabaricane-type triterpenes with trans-syn-trans ring junctions, has been built from a bicyclic γ,δ-unsaturated aldehyde by a reaction sequence incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40e641abeca84256302792dc42d474aa
https://doi.org/10.1016/s0040-4039(99)01240-x
https://doi.org/10.1016/s0040-4039(99)01240-x
Autor:
Franck Raeppel, Denis Heissler
Publikováno v:
Synlett. :2534-2536
The difficult coupling of a geranyl- and an isocopalenyl moiety to form tricyclohexaprenol could be carried out by allylation of isocopalenal with an 8-geranylbarium chloride followed by reduction of the so-formed hindered hydroxy group via a xanthat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e85f49fb71228d1f4fdbaa13e332308
https://doi.org/10.1055/s-2005-917090
https://doi.org/10.1055/s-2005-917090
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2388081ec2e096573e96fd7e56ed24e
https://doi.org/10.1002/chin.199843088
https://doi.org/10.1002/chin.199843088
Publikováno v:
Synlett. 2000:0874-0876
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949eb086592ae5e3fb6dc958f437e2e3
https://doi.org/10.1055/s-2000-6703
https://doi.org/10.1055/s-2000-6703
Autor:
Jeffrey M. Besterman, Naomy Bernstein, Hannah Nguyen, Franck Raeppel, Lijie Zhan, Stephane Raeppel, James Wang, A. Robert MacLeod, Marie-Claude Granger, Ljubomir Isakovic, Stephen William Claridge, Normand Beaulieu, Carole Beaulieu, Oscar Mario Saavedra, Frédéric Gaudette, Arkadii Vaisburg, Isabelle Dupont, Michael Mannion, Nancy Z. Zhou, Robert Deziel
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(24)
A family of thieno[3,2-b]pyridine based small molecule inhibitors of c-Met and VEGFR2 were designed based on lead structure 2. These compounds were shown to have IC(50) values in the low nanomolar range in vitro and were efficacious in human tumor xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64dc57acf05dac78df5d852f13dcfc5
https://pubmed.ncbi.nlm.nih.gov/19896842
https://pubmed.ncbi.nlm.nih.gov/19896842