Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Franck Polleux"'
Autor:
Daniel M. Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J. Park, Victoria L. Hewitt, David Zhang, Kevin C. Gonzalez, Fiona M. Russell, D. Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the a
Externí odkaz:
https://doaj.org/article/4622b875797a4a148a830a6b459942d0
Autor:
Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet-Coello, Sebastien Herzig, Marc Foretz, Benoit Viollet, Reuben Shaw, Andrew Sproul, Franck Polleux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Loss of excitatory synapses occur prior to the formation of amyloid plaques in Alzheimer’s disease. Here the authors show in an animal model that the loss of synapses induced by amyloid-beta oligomers requires over-activation of a stress-response p
Externí odkaz:
https://doaj.org/article/e4cca8864343441c862cd2169b11e9ee
Autor:
Ewoud R. E. Schmidt, Franck Polleux
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2022)
One of the most salient features defining modern humans is our remarkable cognitive capacity, which is unrivaled by any other species. Although we still lack a complete understanding of how the human brain gives rise to these unique abilities, the pa
Externí odkaz:
https://doaj.org/article/34a4c41e894f46889a7ef6bb6b988deb
Autor:
Heike Blockus, Sebi V. Rolotti, Miklos Szoboszlay, Eugénie Peze-Heidsieck, Tiffany Ming, Anna Schroeder, Nuno Apostolo, Kristel M. Vennekens, Phinikoula S. Katsamba, Fabiana Bahna, Seetha Mannepalli, Goran Ahlsen, Barry Honig, Lawrence Shapiro, Joris de Wit, Attila Losonczy, Franck Polleux
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109828- (2021)
Summary: Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in establishing synaptic specificity in hippocampal CA1. In vivo,
Externí odkaz:
https://doaj.org/article/ca93291c525c4a8aa7c919fed9005f37
Autor:
Tamara Zehnder, Francesco Petrelli, Jennifer Romanos, Eva C. De Oliveira Figueiredo, Tommy L. Lewis, Jr., Nicole Déglon, Franck Polleux, Mirko Santello, Paola Bezzi
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108952- (2021)
Summary: The mechanisms controlling the post-natal maturation of astrocytes play a crucial role in ensuring correct synaptogenesis. We show that mitochondrial biogenesis in developing astrocytes is necessary for coordinating post-natal astrocyte matu
Externí odkaz:
https://doaj.org/article/f1df3debacce4887983091ca5960c352
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
It is unclear how and why axonal mitochondria are kept so small in axons. Authors show here that MFF-mediated fission is required for determining the size of mitochondria both entering and along the axon, and this is critical for mitochondrial calciu
Externí odkaz:
https://doaj.org/article/6011499af941422d9a5a9a83b3117271
Autor:
Virginie Courchet, Amanda J. Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L. Lewis, Franck Polleux, Julien Courchet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders
Externí odkaz:
https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6
Autor:
Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L. Lewis Jr., Christopher Conrad, Jonathan M. Rothberg, Jonathan O. Lipton, Stefan Kölker, Georg F. Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1053-1070 (2016)
Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same ti
Externí odkaz:
https://doaj.org/article/5ed8e2bf932447198481e0e69bebd50d
Autor:
Seok-Kyu Kwon, Richard Sando, Tommy L Lewis, Yusuke Hirabayashi, Anton Maximov, Franck Polleux
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e3000040 (2018)
[This corrects the article DOI: 10.1371/journal.pbio.1002516.].
Externí odkaz:
https://doaj.org/article/83f06acd8b48457f8fb0992da6fcbe2d
Autor:
Masafumi Shimojo, Julien Courchet, Simon Pieraut, Nina Torabi-Rander, Richard Sando III, Franck Polleux, Anton Maximov
Publikováno v:
Cell Reports, Vol 11, Iss 7, Pp 1054-1066 (2015)
At presynaptic active zones, exocytosis of neurotransmitter vesicles (SVs) is driven by SNARE complexes that recruit Syb2 and SNAP25. However, it remains unknown which SNAREs promote the secretion of neuronal proteins, including those essential for c
Externí odkaz:
https://doaj.org/article/fcd323bfb0454da59e71731c6fece7f9