Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica

Autor: Carmen Quiñonero López, Patricia Corral, Bénédicte Lorrain-Lorrette, Karen Martinez-Swatson, Franck Michoux, Henrik Toft Simonsen

Publikováno v: Plant Methods, Vol 14, Iss 1, Pp 1-17 (2018)

Abstract Background Thapsigargin and nortrilobolide are sesquiterpene lactones found in the Mediterranean plant Thapsia garganica L. Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum calcium ATPase pump, inducing apoptosis in mamm

Externí odkaz: https://doaj.org/article/18998d9fb45b4057a85346a0c9b1d8c2

Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica

Autor: Franck Michoux, Carmen Quinonero Lopez, Bénédicte Lorrain-Lorrette, Henrik Toft Simonsen, Patricia Corral, Karen Martinez-Swatson

Publikováno v: Plant Methods, Vol 14, Iss 1, Pp 1-17 (2018)
Plant Methods
López, C Q, Corral, P, Lorrain-Lorrette, B, Martinez-Swatson, K, Michoux, F & Simonsen, H T 2018, ' Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica ', Plant Methods, vol. 14, no. 1, 79 . https://doi.org/10.1186/s13007-018-0346-z
Lopez, C Q, Corral, P, Lorrain-Lorrette, B, Martinez-Swatson, K, Michoux, F & Simonsen, H T 2018, ' Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of Thapsia garganica ', Plant Methods, vol. 14, 79, pp. 1-17 . https://doi.org/10.1186/s13007-018-0346-z

Background Thapsigargin and nortrilobolide are sesquiterpene lactones found in the Mediterranean plant Thapsia garganica L. Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum calcium ATPase pump, inducing apoptosis in mammalian cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049913d49b36d7dd2b214ff74b31a80f
http://link.springer.com/article/10.1186/s13007-018-0346-z

Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast

Autor: Alain Goossens, Eleni Lazaridi, Søren Bak, Philipp Arendt, Jean-Etienne Bassard, Aldo Almeida, Jacob Pollier, Franck Michoux, Louisi Souza de Oliveira, Bekzod Khakimov, Lemeng Dong, Georgios Ntallas, Frédéric Lota

Publikováno v: Metabolic Engineering
Metabolic Engineering, Elsevier, 2018, 49, pp.1-12. ⟨10.1016/j.ymben.2018.07.002⟩

Triterpene cyclases catalyze the first committed step in triterpene biosynthesis, by forming mono- to pentacyclic backbone structures from oxygenated C30 isoprenoid precursors. Squalene epoxidase precedes this cyclization by providing the oxygenated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9ba6eb520a49837d650d3665ae318
https://hal.archives-ouvertes.fr/hal-02885736

Triterpene Messages from the EU-FP7 Project TriForC

Autor: Anne Osbourn, Alain Goossens, Franck Michoux, Søren Bak

Publikováno v: Trends in plant science. 23(4)

TriForC is an innovative EU-funded collaborative project that has established an integrative pipeline for the exploitation of plant triterpenes for commercialization in agriculture and pharmacology. We discuss the main outcomes of TriForC and reflect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6691f495ad2108d048eb7266c371260
https://pubmed.ncbi.nlm.nih.gov/29483042

Crystal structure of the Psb28 accessory factor of Thermosynechococcus elongatus photosystem II at 2.3 Å

Autor: Josef Komenda, Franck Michoux, Peter J. Nixon, James W. Murray, Wojciech Bialek, Martina Bečková, Songjia Wen

Publikováno v: Photosynthesis Research. 117:375-383

Members of the Psb28 family of proteins are accessory factors implicated in the assembly and repair of the photosystem II complex. We present here the crystal structure of the Psb28 protein (Tlr0493) found in the thermophilic cyanobacterium Thermosyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5e6787bee8d5a1f3b07d305c4d1cb2
https://doi.org/10.1007/s11120-013-9939-6