Výsledky vyhledávání - "Franck Lemiale"

Akademický článek

Safety and immunogenicity of a thermostable ID93 + GLA-SE tuberculosis vaccine candidate in healthy adults

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Here the authors present results from a randomized, double-blinded Phase 1 clinical trial, testing a thermostable presentation of a clinical-stage adjuvanted subunit tuberculosis vaccine candidate. The vaccine candidate is safe and well tolerated, an

Externí odkaz: https://doaj.org/article/0416e608bded4e49acce0289f6385372

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Akademický článek

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein.

Autor: David Oyen, Jonathan L Torres, Phillip C Aoto, Yevel Flores-Garcia, Špela Binter, Tossapol Pholcharee, Sean Carroll, Sini Reponen, Rachael Wash, Qi Liang, Franck Lemiale, Emily Locke, Allan Bradley, C Richter King, Daniel Emerling, Paul Kellam, Fidel Zavala, Andrew B Ward, Ian A Wilson

Publikováno v: PLoS Pathogens, Vol 16, Iss 3, p e1008373 (2020)

Lasting protection has long been a goal for malaria vaccines. The major surface antigen on Plasmodium falciparum sporozoites, the circumsporozoite protein (PfCSP), has been an attractive target for vaccine development and most protective antibodies s

Externí odkaz: https://doaj.org/article/2b45fbb0cb2843a2913970e92e8e5bed

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Akademický článek

Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

Autor: Stephen W. Scally, Brandon McLeod, Alexandre Bosch, Kazutoyo Miura, Qi Liang, Sean Carroll, Sini Reponen, Ngan Nguyen, Eldar Giladi, Sebastian Rämisch, Vidadi Yusibov, Allan Bradley, Franck Lemiale, William R. Schief, Daniel Emerling, Paul Kellam, C. Richter King, Jean-Philippe Julien

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Plasmodium falciparum protein Pfs25 is a promising malaria transmission blocking vaccine antigen. Here, Scally et al. determine the crystal structure of Pfs25 and identify antigenic sites that are recognized by transmission-blocking antibodies elicit

Externí odkaz: https://doaj.org/article/d1902f6099734fd8a2c75117c776ee4d

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Akademický článek

Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

Autor: Sidhartha Chaudhury, Jason A. Regules, Christian A. Darko, Sheetij Dutta, Anders Wallqvist, Norman C. Waters, Erik Jongert, Franck Lemiale, Elke S. Bergmann-Leitner

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month

Externí odkaz: https://doaj.org/article/da43572f2ab14d5da906e3ca77074fd9

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Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

Autor: Špela Binter, Daniel Emerling, Yevel Flores-Garcia, Sini Reponen, Andrew B. Ward, C. Richter King, Rachael S. Wash, Sean M. Carroll, Paul Kellam, Phillip C. Aoto, Jonathan L. Torres, David Oyen, Fidel Zavala, Allan Bradley, Emily Locke, Franck Lemiale, Ian A. Wilson, Qi Liang, T. Pholcharee

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 3, p e1008373 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c6d0fca680bc5b7a215b61e2d3b555
http://hdl.handle.net/10044/1/81513

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Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25

Autor: Stephen W, Scally, Brandon, McLeod, Alexandre, Bosch, Kazutoyo, Miura, Qi, Liang, Sean, Carroll, Sini, Reponen, Ngan, Nguyen, Eldar, Giladi, Sebastian, Rämisch, Vidadi, Yusibov, Allan, Bradley, Franck, Lemiale, William R, Schief, Daniel, Emerling, Paul, Kellam, C Richter, King, Jean-Philippe, Julien

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications

The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies that inhibit parasite development when ingested by Anopheles mosquitoes during blood meals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::279abaecce8e54bb2d05b0b0f232f200
http://hdl.handle.net/10044/1/70143

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Delayed fractional dose regimen of the RTS,S/AS01 malaria vaccine candidate enhances an IgG4 response that inhibits serum opsonophagocytosis

Autor: Franck Lemiale, Elke S. Bergmann-Leitner, Sheetij Dutta, Norman C. Waters, Anders Wallqvist, Jason A. Regules, Erik Jongert, Christian A. Darko, Sidhartha Chaudhury

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

A recent study of the RTS,S malaria vaccine, which is based on the circumsporozoite protein (CSP), demonstrated an increase in efficacy from 50–60% to 80% when using a delayed fractional dose regimen, in which the standard 0–1–2 month immunizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028781fdab29bf78a5eebbdcc2318ae0
https://pubmed.ncbi.nlm.nih.gov/28801554

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The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity

Autor: Elke S. Bergmann-Leitner, Sheetij Dutta, Franck Lemiale, Jason A. Regules, Erik Jongert, Sidhartha Chaudhury, Christian F. Ockenhouse, Norman C. Waters, Anders Wallqvist

Publikováno v: Malaria Journal

Background Recent vaccine studies have shown that the magnitude of an antibody response is often insufficient to explain efficacy, suggesting that characteristics regarding the quality of the antibody response, such as its fine specificity and functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d523775bc1c039f29f62727c6f246f68
http://europepmc.org/articles/PMC4886414

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Heterologous HIV-based lentiviral/adenoviral vectors immunizations result in enhanced HIV-specific immunity

Autor: Nikolay Korokhov, Franck Lemiale, Benyam Asefa

Publikováno v: Vaccine. 28:3617-3624

Viral vectors are considered as one of the major means for the induction of strong immune responses against recombinant antigens by genetic immunization. Among these, lentiviral vectors are particularly attractive vehicles, as they can infect a wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9407308bf712bf06efb63d61e538a17f
https://doi.org/10.1016/j.vaccine.2009.12.047

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An HIV-based lentiviral vector as HIV vaccine candidate: Immunogenic characterization

Autor: Delia Ye, Christopher Chen, Laurent Humeau, Franck Lemiale, Nikolay Korokhov, Benyam Asefa

Publikováno v: Vaccine. 28:1952-1961

Recently developed viral-vectored HIV vaccine candidates, despite achieving high levels transgene expression and inducing high magnitude immune responses to HIV, have faced limitations related to anti-vector immunity. In contrast, lentiviral vectors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c60deb2f48195e528dc853e986f1074
https://doi.org/10.1016/j.vaccine.2009.10.089

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