Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Franck Duclos"'
Autor:
Mark S Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S Budamagunta, Jacques Genest, Gregory C Shearer, Franck Duclos, Michael N Oda
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71541 (2013)
High density lipoprotein (HDL) cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL are functionally equivalent. A primary determinant of HDL functional status is the conformational adaptability of its main
Externí odkaz:
https://doaj.org/article/1e58836a5d004ecdb31766e8e2e6b96a
Autor:
Javed Khan, Xiaoqin Liu, Sutjano Jusuf, Carol Hui Hu, Gregory A. Locke, Franck Duclos, Ruth R. Wexler, Gerald J. Duke, Joanne M. Smallheer, Ellen K. Kick, Meriah Neissel Valente, O. Scott Halpern
Publikováno v:
Bioorganicmedicinal chemistry letters. 42
Myeloperoxidase (MPO), a critical enzyme in antimicrobial host-defense, has been implicated in chronic inflammatory diseases such as coronary artery disease. The design and evaluation of MPO inhibitors for the treatment of cardiovascular disease are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60d009ac35f0cf724f08285cd374dfa
https://pubmed.ncbi.nlm.nih.gov/33811992
https://pubmed.ncbi.nlm.nih.gov/33811992
Autor:
Arathi Krishnakumar, Lisa M. Kopcho, Michael Basso, Benjamin P. Vokits, Glenn H. Cantor, Sutjano Jusuf, Lei Zhao, Lynn M. Abell, Ashok Dongre, Javed Khan, Steven A. Spronk, Gregory A. Locke, Gerald J. Duke, Andrew Quoc Viet, Scott A. Shaw, Franck Duclos, Ellen K. Kick, Joelle M. Onorato, Charles G. Clark, Ruth R. Wexler, Dilger Andrew K, Ji Gao
Publikováno v:
Bioorganicmedicinal chemistry. 28(22)
Myeloperoxidase (MPO) is a heme peroxidase found in neutrophils, monocytes and macrophages that efficiently catalyzes the oxidation of endogenous chloride into hypochlorous acid for antimicrobial activity. Chronic MPO activation can lead to indiscrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30388866645cc723c34668c20055fd32
https://pubmed.ncbi.nlm.nih.gov/33007547
https://pubmed.ncbi.nlm.nih.gov/33007547
Autor:
Lei Zhao, Scott A. Shaw, Lynn M. Abell, Fred Lo, Gregory A. Locke, Meriah Neissel Valente, Xiaoqin Liu, Paul G. Sleph, Lisa M. Kopcho, Michael Basso, Andrew Quoc Viet, Rangaraj Narayanan, Nicholas R. Wurtz, Franck Duclos, Sutjano Jusuf, Ellen K. Kick, Dilger Andrew K, Ruth R. Wexler, Gayani Fernando, Javed Khan
[Image: see text] Myeloperoxidase (MPO) generates reactive oxygen species that potentially contribute to many chronic inflammatory diseases. A recently reported triazolopyrimidine MPO inhibitor was optimized to improve acid stability and remove methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146ac6bd8e0ed839899be07882101e6
https://europepmc.org/articles/PMC6295853/
https://europepmc.org/articles/PMC6295853/
Autor:
Lynn M. Abell, Scott A. Shaw, David G. Harden, Meriah Neissel Valente, Sylwia Stachura, Xiaoqin Liu, Kristen Pike, Ellen K. Kick, Kimberly Nowak, Benjamin P. Vokits, Andrew Quoc Viet, Nicholas R. Wurtz, Ji Gao, Javed Khan, Gayani Fernando, Gerald J. Duke, Ruth R. Wexler, Franck Duclos, Gregory A. Locke, Lei Zhao, Ashok Dongre, Paul G. Sleph, David A. Gordon
Publikováno v:
MedChemComm. 8(11)
Myeloperoxidase, a mammalian peroxidase involved in the immune system as an anti-microbial first responder, can produce hypochlorous acid in response to invading pathogens. Myeloperoxidase has been implicated in several chronic pathological diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6938309a24e135aae00aaf681ec2a84d
https://pubmed.ncbi.nlm.nih.gov/30108726
https://pubmed.ncbi.nlm.nih.gov/30108726
Autor:
Rachid Essalmani, Bowman Miao, Franck Duclos, Josée Hamelin, Gerald J. Duke, Suzanne Benjannet, Nabil G. Seidah, Yascara Grisel Luna Saavedra, Marie-Claude Asselin, Rex A. Parker, Gaétan Mayer, Peter A. Lemaire, Antonella Pasquato
Publikováno v:
Journal of Biological Chemistry. 285:40965-40978
PCSK9, a target for the treatment of dyslipidemia, enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes, up-regulating LDL-cholesterol levels. Whereas the targeting and degradation of the PCSK9-LDLR complex are under scrutiny, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6e47989049dcecb9f3e908555dec41
https://doi.org/10.1074/jbc.m110.154815
https://doi.org/10.1074/jbc.m110.154815
Autor:
Viviane Poupon, Peter S. McPherson, Mark R. Witmer, Rex A. Parker, Franck Duclos, Kévin Ly, Steve Poirier, R Day, Annik Prat, Nabil G. Seidah, Marie-Claude Asselin, Roxane Desjardins, Gaétan Mayer
Publikováno v:
Journal of Biological Chemistry. 284:28856-28864
Elevated levels of plasma low density lipoprotein (LDL)-cholesterol, leading to familial hypercholesterolemia, are enhanced by mutations in at least three major genes, the LDL receptor (LDLR), its ligand apolipoprotein B, and the proprotein convertas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88550437c7d30f03fa122be97cbdab91
https://doi.org/10.1074/jbc.m109.037085
https://doi.org/10.1074/jbc.m109.037085
Autor:
Franck Duclos
Publikováno v:
Regards. :147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba22798a62fb0bd6a727283dd84f234
https://doi.org/10.3917/regar.051.0147
https://doi.org/10.3917/regar.051.0147
Autor:
Jack H. Van Der Meulen, Steven A. Moore, Kathleen H. Holt, Connie S. Lebakken, Leland E. Lim, Kevin P. Campbell, David Venzke, Audrey J. Ettinger, Franck Duclos, Rachelle H. Crosbie, Madeleine Durbeej, John A. Faulkner, Roger A. Williamson, Joshua R. Sanes, Ron F. Hrstka, Volker Straub, Beverly L. Davidson
Publikováno v:
The Journal of Cell Biology
Limb-girdle muscular dystrophy type 2D (LGMD 2D) is an autosomal recessive disorder caused by mutations in the alpha-sarcoglycan gene. To determine how alpha-sarcoglycan deficiency leads to muscle fiber degeneration, we generated and analyzed alpha-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6840e07b9dc703cbad7400589d624bfc
https://doi.org/10.1083/jcb.142.6.1461
https://doi.org/10.1083/jcb.142.6.1461
Autor:
Michael N. Oda, Nancy L. Carson, Gregory C. Shearer, Mark S. Borja, Xiaoqin Liu, Chongren Tang, Gayani Fernando, Franck Duclos, Lei Zhao, Bradley Hammerson, Madhu S. Budamagunta, Jacques Genest, Richard Yang
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71541 (2013)
PLoS ONE
PLoS ONE
High density lipoprotein (HDL) cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL are functionally equivalent. A primary determinant of HDL functional status is the conformational adaptability of its main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e530a80ec53636bfd0129e70ffafbf5
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24015188/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24015188/?tool=EBI