Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Franck Alexandre Silva"'
Autor:
Apostolia Maria Tsimberidou, Cara Haymaker, Franck Alexandre Silva, Simin Kiany, Kemal Haque, Lucy Coe, Carrie Cartwright, Helen Berryman, Graciela M. Nogueras-Gonzalez, James Dow, David Vining, Alexander Richard Liam Cecil, Henry H. Vo, Elisabeth A. Bone, Ignacio I. Wistuba, Philip A. Beer, Hilary McElwaine-Johnn
Publikováno v:
Clinical Cancer Research. 27:3584-3594
Purpose: Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study describes the development of a novel HDAC6 inhibitor. Patients and Methods: KA2507
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa6f156927db60cbf7c47ada3193d33
https://doi.org/10.1158/1078-0432.ccr-21-0238
https://doi.org/10.1158/1078-0432.ccr-21-0238
Autor:
Kemal Haque, Loretta J. Nastoupil, Jason R. Westin, Letitia Lensun, Michael Wang, Sattva S. Neelapu, Hilary McElwaine-Johnn, Felipe Samaniego, Hun Ju Lee, James Dow, Nathan Fowler, Alexander Richard Liam Cecil, Richard E. Davis, Andrew David Whale, Elisabeth A. Bone, Fredrick B. Hagemeister, Philip A Beer, Franck Alexandre Silva
Publikováno v:
Leukemialymphoma. 62(14)
PI3-kinase p110δ is mainly expressed in lymphocytes and is an attractive therapeutic target in B cell lymphomas. Targeting p110β may further suppress tumor growth and overcome escape mechanisms. KA2237 is an oral, potent, dual p110β/p110δ inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631b617f5bd317661550f9fc922d956f
https://pubmed.ncbi.nlm.nih.gov/34365878
https://pubmed.ncbi.nlm.nih.gov/34365878
Autor:
Sattva S. Neelapu, Penny Ward, James Dow, Fredrick B. Hagemeister, Franck Alexandre Silva, Duncan McHale, Nathan Fowler, Stephen J. Shuttleworth, Hun Ju Lee, Jason R. Westin, Alexander Richard Liam Cecil, Michael Wang, Philip A. Beer, Felipe Samaniego, Arash Yavari, Loretta J. Nastoupil, Eric Davis
Publikováno v:
Blood. 134:4099-4099
Introduction: Despite therapeutic advances, there remains a considerable need for novel therapies for B-cell lymphomas. Although a high proportion of patients (pts) show response to initial therapy, many fail to achieve durable remissions and experie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d61b6e81139400b878e10c826d84264c
https://doi.org/10.1182/blood-2019-130401
https://doi.org/10.1182/blood-2019-130401
Publikováno v:
Angewandte Chemie International Edition. 47:7927-7930
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a492ac4155fd70881724411b3038d70e
https://doi.org/10.1002/anie.200802162
https://doi.org/10.1002/anie.200802162
Autor:
Thomas James Hill, Cyrille Davy Tomassi, Rebecca Harrison, Alexander Richard Liam Cecil, Helen L. Rogers, Stephen Shuttleworth, Franck Alexandre Silva, Paul A. Townsend
Publisher Summary In addition to small molecule therapeutics, a number of biological therapies that regulate Th17 cell activity have been discovered over the past decade. Researchers at Schering Corp. have disclosed the identification of antibody- an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0446e7fdf2064efa9ef485753ec41c4c
https://doi.org/10.1016/b978-0-12-381290-2.00003-3
https://doi.org/10.1016/b978-0-12-381290-2.00003-3
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25b60d3501a02d4a8dcdeb3ab950824
https://doi.org/10.1002/chin.200905138
https://doi.org/10.1002/chin.200905138
Autor:
Thomas James Hill, Helen L. Rogers, Franck Alexandre Silva, Paul A. Townsend, Cyrille Davy Tomassi, Stephen Shuttleworth, Alexander Richard Liam Cecil
Publikováno v:
Progress in Medicinal Chemistry ISBN: 9780444533586
Publisher Summary The phosphoinositide 3-kinases (PI3Ks) constitute a family of lipid kinases involved in the regulation of a network of signal transduction pathways that control a range of cellular processes. A number of ATP-competitive, small molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde492d1d4d14ad84f8cfb21eaeb782a
https://doi.org/10.1016/s0079-6468(09)04803-6
https://doi.org/10.1016/s0079-6468(09)04803-6
Publikováno v:
Organic letters. 8(23)
[Structure: see text] For the first time, unmodified ynones were used in organocatalytic asymmetric aldol reactions delivering monoprotected anti-alpha,beta-dihydroxyynones in high yields, dr's up to 19:1, and ee's up to 95%. These products can be ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41e22050770bd1733dd3996b99e6af4
https://pubmed.ncbi.nlm.nih.gov/17078732
https://pubmed.ncbi.nlm.nih.gov/17078732
Publikováno v:
Angewandte Chemie. 120:7888-7888
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0931ecd83ab75be565bd512f42dc6d17
https://doi.org/10.1002/ange.200890256
https://doi.org/10.1002/ange.200890256
Publikováno v:
Angewandte Chemie International Edition. 47:7774-7774
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac03440a0bcda6eae12ed9dd23228074
https://doi.org/10.1002/anie.200890202
https://doi.org/10.1002/anie.200890202