Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Franck Suzenet"'
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107047- (2024)
The 5-hydroxytryptamine 7 receptor (5-HT7) is necessary for 5-HT to cause a concentration-dependent vascular relaxation and hypotension. 5-HT7 is recognized as having biased signaling, transduced through either Gs or β -arrestin. It is unknown wheth
Externí odkaz:
https://doaj.org/article/342e21f4d0ad4ee79f6ca65f2ca09868
Akademický článek
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Autor:
Abdelmoula El Abbouchi, Khaoula Mkhayar, Souad Elkhattabi, Nabil El Brahmi, Marie-Aude Hiebel, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 29, Iss 7, p 1437 (2024)
In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported. The synthesised compounds were screened for their a
Externí odkaz:
https://doaj.org/article/fdf8dde43bea4853a0b9e3e4ad474c90
Autor:
Abdelmoula El Abbouchi, Nabil El Brahmi, Marie-Aude Hiebel, Hamza Ghammaz, Elmostafa El Fahime, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 28, Iss 2, p 910 (2023)
The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (EA) analogs (6–10) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the aim to increase the chemical r
Externí odkaz:
https://doaj.org/article/0781e66ac80c490283c6d670e360f1d0
Autor:
Otmane Bourzikat, Abdelmoula El Abbouchi, Hamza Ghammaz, Nabil El Brahmi, Elmostfa El Fahime, Arnaud Paris, Richard Daniellou, Franck Suzenet, Gérald Guillaumet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 27, Iss 16, p 5238 (2022)
In the present study, new 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazines bearing sulfonamides were synthesized, characterized and evaluated for their anticancer activities. The structures of these derivatives were elucidated by 1H NMR, 13C NMR
Externí odkaz:
https://doaj.org/article/8fc3ca29fdfa4dc9ab282d857c3b768c
Autor:
Ilona Gurgul, Ewelina Janczy-Cempa, Olga Mazuryk, Małgorzata Lekka, Michał Łomzik, Franck Suzenet, Philippe C. Gros, Małgorzata Brindell
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (15), pp.10459-10470. ⟨10.1021/acs.jmedchem.2c00580⟩
Journal of Medicinal Chemistry, 2022, 65 (15), pp.10459-10470. ⟨10.1021/acs.jmedchem.2c00580⟩
International audience; The effect of polypyridyl Ru(II) complexes on the ability of cancer cells to migrate and invade, two features important in the formation of metastases, is evaluated. In vitro studies are carried out on breast cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26a8a5679a5e92f24cf27ff67b9ed90
https://doi.org/10.1021/acs.jmedchem.2c00580
https://doi.org/10.1021/acs.jmedchem.2c00580
Autor:
Khadija Gambouz, Abdelmoula El Abbouchi, Sarah Nassiri, Franck Suzenet, Mostapha Bousmina, Mohamed Akssira, Gérald Guillaumet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 25, Iss 12, p 2820 (2020)
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and
Externí odkaz:
https://doaj.org/article/6aad5dbc50664a88be96b462eec6b0fd
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 282-286 (2014)
Substituted 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been synthesized with the inverse electron-demand Diels–Alder reaction from 1,2,4-triazines bearing an acylamino group with a terminal alkyne side chain. Alkynes were first subjected to the S
Externí odkaz:
https://doaj.org/article/a6b25064c9674d75b6f6fe3339c3d13e
Autor:
Hassan Allouchi, Gérald Guillaumet, Adriana-Luminiţa Fînaru, Franck Suzenet, Nicu-Cosmin Ostache, Marie-Aude Hiebel
Publikováno v:
RSC Advances. 11:9756-9765
Despite the pharmacological potential of the pyrazolo[3,4-c]pyrazoles, only a few methods of preparation and direct functionalization of this moiety have been described. We report herein a convenient design of new pyrazolo[3,4-c]pyrazoles with a high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e54513313ea0474b7352a83eef29bc2
https://doi.org/10.1039/d1ra00314c
https://doi.org/10.1039/d1ra00314c
Autor:
Johnny, Vercouillie, Frédéric, Buron, Sophie, Sérrière, Nuno, Rodrigues, Zuhal, Gulhan, Agnès, Chartier, Gabrielle, Chicheri, Hamid, Marzag, Adeline, Oury, Nathalie, Percina, Sylvie, Bodard, Rajah, Ben Othman, Julie, Busson, Franck, Suzenet, Denis, Guilloteau, Mathieu, Marchivie, Patrick, Emond, Sylvain, Routier, Sylvie, Chalon
Publikováno v:
European journal of medicinal chemistry. 244
Age-related neurodegenerative diseases have in common the occurrence of cognitive impairment, a highly incapacitating process that involves the cholinergic neurotransmission system. The vesicular acetylcholine transporter (VAChT) positron emission to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e741084a39e3c6ac3e6cf5e4cc49aa7d
https://pubmed.ncbi.nlm.nih.gov/36252395
https://pubmed.ncbi.nlm.nih.gov/36252395