Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections

Autor: Maxime Fusade-Boyer, Gabriel Dupré, Pierre Bessière, Samira Khiar, Charlotte Quentin-Froignant, Cécile Beck, Sylvie Lecollinet, Marie-Anne Rameix-Welti, Jean-François Eléouët, Frédéric Tangy, Barbora Lajoie, Stéphane Bertagnoli, Pierre-Olivier Vidalain, Franck Gallardo, Romain Volmer

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

The guanabenz derivative Sephin1 has recently been proposed to increase the levels of translation initiation factor 2 (eIF2α) phosphorylation by inhibiting dephosphorylation by the protein phosphatase 1—GADD34 (PPP1R15A) complex. As phosphorylatio

Externí odkaz: https://doaj.org/article/dbb3af93feb94b83ae4b64f180564cce

Tracing Baculovirus AcMNPV Infection Using a Real-Time Method Based on ANCHORTM DNA Labeling Technology

Autor: Aurélie Hinsberger, Benoît Graillot, Christine Blachère Lopez, Sylvie Juliant, Martine Cerutti, Linda A. King, Robert D. Possee, Franck Gallardo, Miguel Lopez Ferber

Publikováno v: Viruses, Vol 12, Iss 1, p 50 (2020)

Many steps in the baculovirus life cycle, from initial ingestion to the subsequent infection of all larval cells, remain largely unknown; primarily because it has hitherto not been possible to follow individual genomes and their lineages. Use of ANCH

Externí odkaz: https://doaj.org/article/4241b069683a49759fddf5c4d30bb781

Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations

Autor: Gaëlle Frenois-Veyrat, Franck Gallardo, Olivier Gorgé, Elie Marcheteau, Olivier Ferraris, Artem Baidaliuk, Anne-Laure Favier, Cécile Enfroy, Xavier Holy, Jérémy Lourenco, Rhéa Khoury, Flora Nolent, Douglas W. Grosenbach, Dennis E. Hruby, Audrey Ferrier, Frédéric Iseni, Etienne Simon-Loriere, Jean-Nicolas Tournier

Publikováno v: Nature microbiology. 7(12)

The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. We isolated and sequenced a virus from the first clinical MPXV case diagnosed in France (May 2022). We report that tecovirimat (ST-246), a US Food and Drug Ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb5665a4d1ab240871608861f4feca3
https://pubmed.ncbi.nlm.nih.gov/36344621

A3- and A2B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection

Autor: Franck Gallardo, Léo Bucher, Nicolas Desbois, Sandrine Kappler-Gratias, Kerstin Bystricky, Claude P. Gros

Publikováno v: RSC Medicinal Chemistry. 11:771-782

Human cytomegalovirus (hCMV) is responsible for several pathologies impacting immunocompromised patients and can trigger life-threatening infection. Several antivirals are available and are used in the clinic, but hCMV resistant strains have appeared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::291a349c1954f3b6518d2524d51dfba6
https://doi.org/10.1039/d0md00034e

ANCHOR: A Technical Approach to Monitor Single-Copy Locus Localization in Planta

Autor: Anis Meschichi, Mathieu Ingouff, Claire Picart, Marie Mirouze, Sophie Desset, Franck Gallardo, Kerstin Bystricky, Nathalie Picault, Stefanie Rosa, Frédéric Pontvianne

Publikováno v: Frontiers in Plant Science
Frontiers in Plant Science, 2021, 12, pp.677849. ⟨10.3389/fpls.2021.677849⟩
Frontiers in Plant Science, Frontiers, 2021, 12, pp.677849. ⟨10.3389/fpls.2021.677849⟩

Together with local chromatin structure, gene accessibility, and the presence of transcription factors, gene positioning is implicated in gene expression regulation. Although the basic mechanisms are expected to be conserved in eukaryotes, less is kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b48bf3cab3d403e22c867fe6ff32fb79
https://zenodo.org/record/6256647