A receptor-independent signaling pathway for BDNF

Autor: Julia Fath, Franck Brouillard, Alexandre Cabaye, Damien Claverie, Philippe Nuss, Victoria Poillerat, Serge Chwetzoff, Tahar Bouceba, Elodie Bouvier, Myriam Salameh, Jenny Molet, Aïda Padilla-Ferrer, Philippe Couvert, Francine Acher, Marie-Pierre Golinelli-Cohen, Gérard Chassaing, Germain Trugnan, Christophe Bernard, Jean-Jacques Benoliel, Chrystel Becker

In addition to its well-known receptor-mediated function in cell survival, differentiation and growth, we report that the extracellular brain-derived neurotrophic factor (BDNF) also controls the intracellular KEAP1-NRF2 cytoprotective system by a rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aba513608c2627c17b99ec1ae34a0787
https://doi.org/10.1101/2022.08.23.504973

Aspirin and Some Other Nonsteroidal Anti-Inflammatory Drugs Inhibit Cystic Fibrosis Transmembrane Conductance Regulator Protein Gene Expression in T-84 Cells

Autor: Danielle Tondelier, Franck Brouillard, Joanna Lipecka, Régis Labarthe, Moëz Bali, Marie-Ayliette Costa De Beauregard, Tanja Torossi, Marc Cougnon, Aleksander Edelman, Maryvonne Baudouin-Legros

Publikováno v: Mediators of Inflammation, Vol 8, Iss 4-5, Pp 219-227 (1999)

Cystic fibrosis (CF) is caused by mutations in the CF gene, which encodes CF transmembrane conductance regulator protein (CFTR), a transmembrane protein that acts as a cAMP-regulated chloride channel. The disease is characterized by inflammation but

Externí odkaz: https://doaj.org/article/fd397c2a1fa842c49bb98b3c5f4f4a5b

Peroxiredoxin 6 fails to limit phospholipid peroxidation in lung from Cftr-knockout mice subjected to oxidative challenge.

Autor: Stéphanie Trudel, Mairead Kelly, Janine Fritsch, Thao Nguyen-Khoa, Patrice Thérond, Martine Couturier, Michal Dadlez, Janusz Debski, Lhousseine Touqui, Benoit Vallée, Mario Ollero, Aleksander Edelman, Franck Brouillard

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e6075 (2009)

Oxidative stress plays a prominent role in the pathophysiology of cystic fibrosis (CF). Despite the presence of oxidative stress markers and a decreased antioxidant capacity in CF airway lining fluid, few studies have focused on the oxidant/antioxida

Externí odkaz: https://doaj.org/article/dd0f0ca8b1b247e1959498a2a7549e9f

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

Autor: Jean-Jacques Benoliel, Christophe Bernard, C. Rivat, N. Doligez, Franck Brouillard, J. Molet, N. Cresto, Bouvier E, Kim Q. Do, Jan-Harry Cabungcal, Christel Becker, Damien Claverie

Publikováno v: Molecular psychiatry, vol. 22, no. 12, pp. 1701-1713
Molecular Psychiatry
Molecular Psychiatry, Nature Publishing Group, 2017, 22 (12), pp.1701-1713. ⟨10.1038/mp.2016.144⟩

Stressful life events produce a state of vulnerability to depression in some individuals. The mechanisms that contribute to vulnerability to depression remain poorly understood. A rat model of intense stress (social defeat (SD), first hit) produced v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8e09be48d03fcdae9287e4c51714ba
https://serval.unil.ch/notice/serval:BIB_65FE79A8973A

GSH monoethyl ester rescues mitochondrial defects in cystic fibrosis models

Autor: Franck Brouillard, Maryvonne Baudouin-Legros, Sandra Moriceau, Thao Nguyen-Khoa, Mario Ollero, Ludovic Jeanson, Stéphanie Trudel, Janine Fritsch, Corine Matar, Fatima Djouadi, Marc Conti, Mairead Kelly-Aubert, Aleksander Edelman

Publikováno v: Human Molecular Genetics. 20:2745-2759

Cystic fibrosis (CF), a multisystem disease caused by CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations, is associated with an abnormal inflammatory response and compromised redox homeostasis in the airways. Recent evidence su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6b787f1d155bd93b9064a301e3eb69
https://doi.org/10.1093/hmg/ddr173