Výsledky vyhledávání - "Francisney Pinto do Nascimento"

Inosine as a Tool to Understand and Treat Central Nervous System Disorders: A Neglected Actor?

Autor: Fernando Cezar-Dos-Santos, Francisney Pinto do Nascimento, Fernanda Rocha Lapa-Costa, Sérgio José Macedo-Júnior, Adair R.S. Santos

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)

Since the 1970s, when ATP was identified as a co-transmitter in sympathetic and parasympathetic nerves, it and its active metabolite adenosine have been considered relevant signaling molecules in biological and pathological processes in the central n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de63f61d325f87739cd7160e4b767923

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The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior

Autor: Francisney Pinto do Nascimento, Sérgio José Macedo-Júnior, Murilo Luiz-Cerutti, Adair R.S. Santos

Publikováno v: Purinergic Signal

The role of peripheral adenosine receptors in pain is a controversial issue and seems to be quite different from the roles of spinal and central adenosine receptors. The present study is aimed at clarifying the role of these receptors in peripheral n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9319e5e9e4e63a2fb3c414b58ed16459
https://pubmed.ncbi.nlm.nih.gov/33860899

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Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice

Autor: Murilo Luiz-Cerutti, Daniel Martins, M.D. da Silva, R.P. Cremonese, Fábio Rodrigo Mesquita Borges, Sérgio José Macedo-Júnior, Ana Lúcia S. Rodrigues, Adair R.S. Santos, Francisney Pinto do Nascimento

Publikováno v: Neuroscience. 303:51-58

Background: It has been shown that chronic pain is able to induce depressive disorders in humans, in part, due to peripheral inflammation that reaches the central nervous system. However, the mechanisms involved remain to be established. The purpose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c1e10a77d45bed43f3da7010b9b7d5
https://doi.org/10.1016/j.neuroscience.2015.06.044

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Adenosine A1 Receptor-Dependent Antinociception Induced by Inosine in Mice: Pharmacological, Genetic and Biochemical Aspects

Autor: Rafael C. Dutra, Francisney Pinto do Nascimento, Fabrício A. Pamplona, João B. Calixto, Adair R.S. Santos, Sérgio José Macedo-Júnior, Murilo Luiz-Cerutti, Jana Sawynok, Marina Machado Córdova, Carla I. Tasca, Leandra C. Constantino, Allison Reid

Publikováno v: Molecular Neurobiology. 51:1368-1378

Inosine is an endogenous nucleoside that has anti-inflammatory and antinociceptive properties. Inosine is a metabolite of adenosine, and some of its actions suggest the involvement of adenosine A1 receptors (A1Rs). The purpose of this study was to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdd3c987dd00702c029840c201718f8
https://doi.org/10.1007/s12035-014-8815-5

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Ankle Joint Mobilization Decreases Hypersensitivity by Activation of Peripheral Opioid Receptors in a Mouse Model of Postoperative Pain

Autor: Adair R.S. Santos, Vinicius M. Gadotti, Francisney Pinto do Nascimento, Francisco José Cidral-Filho, Franciane Bobinski, Leidiane Mazzardo-Martins, Daniel Martins

Publikováno v: Pain Medicine. 13:1049-1058

Objective. Investigate whether ankle joint mobilization (AJM) decreases hypersensitivity in the mouse plantar incision (PI) model of postoperative pain as well as to analyze the possible mechanisms involved in this effect. Design. Experiment 1: PI ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b64f9e6d83917d1533e79202ccd15f2
https://doi.org/10.1111/j.1526-4637.2012.01438.x

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Role of pertussis toxin-sensitive G-protein, K+ channels, and voltage-gated Ca2+ channels in the antinociceptive effect of inosine

Autor: Murilo Luiz-Cerutti, Sérgio José Macedo-Júnior, Francisney Pinto do Nascimento, Adair R.S. Santos

Publikováno v: Purinergic Signalling. 9:51-58

Inosine is the first metabolite of adenosine. It exerts an antinociceptive effect by activating the adenosine A(1) and A(2A) receptors. We have previously demonstrated that inosine exhibits antinociceptive properties in acute and chronic mice models

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dd97967a4a9981bcfd7d6a034d636f
https://doi.org/10.1007/s11302-012-9327-2

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The Antinociceptive Effects of AR-A014418, a Selective Inhibitor of Glycogen Synthase Kinase-3 Beta, in Mice

Autor: Adair R.S. Santos, Manuela G. López, Leidiane Mazzardo-Martins, Francisney Pinto do Nascimento, Daniel Martins, Vinicius M. Gadotti, Angelo O. Rosa, Javier Egea

Publikováno v: The Journal of Pain. 12:315-322

We investigated the antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3β (GSK-3β) in mice. A 30-minute pretreatment with AR-A014418 (.1 and 1 mg/kg, intraperitoneal [ip]) inhibited nociception induced by an ip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48a5caf6adde01857db96c1f9de7978
https://doi.org/10.1016/j.jpain.2010.06.007

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Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate

Autor: Francisney Pinto do Nascimento, Maria Fernanda de Paula Werner, Cristian Soldi, Moacir Geraldo Pizzolatti, Cristiane Hatsuko Baggio, Cristina Setim Freitas, Adair R.S. Santos, Rodrigo Marcon, Ana Paula Luiz

Publikováno v: Brain Research. 1295:76-88

Previous studies from our group investigated the antinociceptive property of amyrin octanoate, a synthetic compound derivative from natural precursor alpha, beta-amyrin, against nociceptive response induced by acetic acid and formalin. Here, we inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd1282d454374c3a7dbad1778b7d72
https://doi.org/10.1016/j.brainres.2009.07.073

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Antinociceptive Effect of the Polygala sabulosa Hydroalcoholic Extract in Mice: Evidence for the Involvement of Glutamatergic Receptors and Cytokine Pathways

Autor: Moacir Geraldo Pizzolatti, Flavia Carla Meotti, Francisney Pinto do Nascimento, Beatriz G. Mendes, Ana Lúcia S. Rodrigues, Cristian Soldi, Alcir Luiz Dafre, Adair R.S. Santos, Marcelo Farina, Amanda V. Jacques, Camila M. Ribas

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 103:43-47

This study investigated the role of the glutamatergic system on the antinociception caused by Polygala sabulosa hydroalcoholic extract (HE). The systems mediated by substance P, capsaicin, interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd722595b1fea5c0f3c0555c51938601
https://doi.org/10.1111/j.1742-7843.2008.00245.x

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