Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Francisco de Asís Balaguer"'
1
Structural model for differential cap maturation at growing microtubule ends
Autor: Isabel Barasoain, Andrea E. Prota, J. Fernando Díaz, Francisco de Asís Balaguer, Christina Kamma-Lorger, Siou Ku, María A. Oliva, Rubén M. Buey, Toshiki Yagi, Laurence Duchesne, Denis Chrétien, Daniel Lucena-Agell, Shinji Kamimura, Juan Estévez-Gallego, Michel O. Steinmetz, Hiroyuki Iwamoto, Fernando Josa-Prado
Publikováno v: eLife
eLife, eLife Sciences Publication, 2020, 9, pp.e50155. ⟨10.7554/eLife.50155⟩
Digital.CSIC. Repositorio Institucional del CSIC
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'eLife ', vol: 9, pages: e50155-1-e50155-26 (2020)
eLife, Vol 9 (2020)
eLife, 2020, 9, pp.e50155. ⟨10.7554/eLife.50155⟩
26 p.-5 fig.-5 tab.
Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs, GTP hydrolysis triggers structural chan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f00c01fd31baf004ef430cbc4a55d6
https://hal.archives-ouvertes.fr/hal-02552246/file/hal-02552246.pdf
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3
Synthesis of thicolchicine‐based conjugates: investigation towards bivalent tubulin/microtubules binders
Autor: Daniele Passarella, Stefano Pieraccini, Maurizio Sironi, Cristina Marucci, Federico Dapiaggi, Francisco de Asís Balaguer, Francesca Foschi, Michael S. Christodoulou, J. Fernando Díaz, Elisa Bonandi, Nace Zidar
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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5 p.-4 fig.-1 tab.-2 schem + 10 p. inf. supl.
Four different hybrid compounds have been efficiently synthesized by conjugation of deacetylthiocolchicine with pironetin‐inspired derivatives. The modest bioactivity and the apparent absence of in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799fa795e06f62755748c72d9f6fb176
http://hdl.handle.net/10261/199766
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5
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands
Autor: María A. Oliva, Karl-Heinz Altmann, Erik J. Sorensen, Juan Estévez-Gallego, Andrea E. Prota, Juan F. Giménez-Abián, J. Fernando Díaz, April L. Risinger, Michel O. Steinmetz, Christopher D. Vanderwal, Tobias Mühlethaler, Enrique Calvo, Francisco de Asís Balaguer, Susan L. Mooberry
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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International Journal of Molecular Sciences, 20 (6)
International Journal of Molecular Sciences
Volume 20
Issue 6
Repisalud
Instituto de Salud Carlos III (ISCIII)
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1392 (2019)
It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin activation is modulation of the structure of a switch element (the M-loop) from a disordered form in dimeric tubulin to a folded helical structure in microtubules.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9cfd00b1f1ee769e381ac20f964e74
http://hdl.handle.net/10261/178957
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6
Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin
Autor: Javier Rodríguez-Salarichs, Ángeles Canales, Isabel Barasoain, Ruth Matesanz, Ashwani Sharma, Clemens Lamberth, Francisco de Asís Balaguer, Michel O. Steinmetz, Hugo Muñoz-Hernández, Gonzalo Sáez-Calvo, Manuel Álvaro Berbís, Natacha Olieric, Sebastian Wendeborn, Andrea E. Prota, Miguel A. Peñalva, José Fernando Díaz, Jesús Jiménez-Barbero, José Manuel Andreu
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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53 p.-7 fig.+ 7 p.-1 tab.supl.-6 fig.supl. Saez Calvo, Gonzalo et al.
Microtubule-targeting agents (MTAs) are some of the clinically most successful anti-cancer drugs. Unfortunately, instances of multidrug resistances to MTA have been reported,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6dc9ad1d81467f15e05e4f0578371de
http://hdl.handle.net/10261/152590
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7
Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin
Autor: Clemens Lamberth, Ashwani Sharma, Michel O. Steinmetz, Isabel Barasoain, J. Fernando Díaz, Francisco de Asís Balaguer, Natacha Olieric, Gonzalo Sáez-Calvo
Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 7, p 1336 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 7; Pages: 1336
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences
Quinolin-6-yloxyacetamides (QAs) are a chemical class of tubulin polymerization inhibitors that were initially identified as fungicides. Here, we report that QAs are potent anti-proliferative agents against human cancer cells including ones that are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1acfaf4b559f093d2c8a02a339f7b9
https://doi.org/10.3390/ijms18071336
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8
Akademický článek
CTP promotes efficient ParB-dependent DNA condensation by facilitating one-dimensional diffusion from parS
Autor: Francisco de Asis Balaguer, Clara Aicart-Ramos, Gemma LM Fisher, Sara de Bragança, Eva M Martin-Cuevas, Cesar L Pastrana, Mark Simon Dillingham, Fernando Moreno-Herrero
Publikováno v: eLife, Vol 10 (2021)
Faithful segregation of bacterial chromosomes relies on the ParABS partitioning system and the SMC complex. In this work, we used single-molecule techniques to investigate the role of cytidine triphosphate (CTP) binding and hydrolysis in the critical
Externí odkaz: https://doaj.org/article/d79c0ace754d457badcfaefe3e56d7ca
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