Zobrazeno 1 - 10
of 492
pro vyhledávání: '"Francisco X-Real"'
Autor:
Pilar Bustamante-Madrid, Antonio Barbáchano, David Albandea-Rodríguez, Javier Rodríguez-Cobos, Nuria Rodríguez-Salas, Isabel Prieto, Aurora Burgos, Jaime Martínez de Villarreal, Francisco X. Real, José Manuel González-Sancho, María Jesús Larriba, Miguel Lafarga, Alberto Muñoz, Asunción Fernández-Barral
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-16 (2024)
Abstract Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address these questions but studies are
Externí odkaz:
https://doaj.org/article/1747eea4e0c942f3bab2ba3f194d57d3
Autor:
Lara Andreoli, Catalina Berca, Sonja Katz, Maryna Korshevniuk, Ritchie M. Head, Kristel Van Steen, TranSYS Consortium, Kris Dierickx, Federico Melograna, Zuqi Li, Giada Lalli, Johan M. Kros, Shiva Najjary, Damjana Rozman, Andrew Walakira, Alexander Skupin, Elle Wilson, Francisco X. Real, Benno Schwikowski, Behnam Yousefi, Nataša Pržulj, Katarina Mihajlovic, Elisabeth B. Binder, Nahid Taheri, Anastasiia Hryhorzhevska, Lude Franke, George P. Patrinos, Kariofyllis Karamperis, Oscar Lao, Vitor A. P. Martins dos Santos, Christina Olsen, Ritchie Head
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionIn the evolving healthcare landscape, precision medicine's rise necessitates adaptable doctoral training. The European Union has recognized this and promotes the development of international, training-focused programmes called Innovative
Externí odkaz:
https://doaj.org/article/33e1667ff3424246bdd333e44becb2c0
Autor:
Isidoro Cobo, Sumit Paliwal, Cristina Bodas, Irene Felipe, Júlia Melià-Alomà, Ariadna Torres, Jaime Martínez-Villarreal, Marina Malumbres, Fernando García, Irene Millán, Natalia del Pozo, Joo-Cheol Park, Ray J. MacDonald, Javier Muñoz, Raúl Méndez, Francisco X. Real
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites are enriched in NR5A2 ChIP-Seque
Externí odkaz:
https://doaj.org/article/03318fd6a1184623b04fb131e80fac48
Autor:
Albert Font, Montserrat Domenech, Jose Luis Ramirez, Miriam Marqués, Raquel Benítez, Vicenç Ruiz de Porras, José L. Gago, Cristina Carrato, Francesc Sant, Hector Lopez, Daniel Castellano, Nuria Malats, M. Luz Calle, Francisco X. Real
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Background and objectiveNeoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopatholog
Externí odkaz:
https://doaj.org/article/d5f1dbc0eda140979411c776bbf1ff57
Autor:
Sia Viborg Lindskrog, Frederik Prip, Philippe Lamy, Ann Taber, Clarice S. Groeneveld, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Trine Strandgaard, Iver Nordentoft, Emil Christensen, Mateo Sokac, Nicolai J. Birkbak, Lasse Maretty, Gregers G. Hermann, Astrid C. Petersen, Veronika Weyerer, Marc-Oliver Grimm, Marcus Horstmann, Gottfrid Sjödahl, Mattias Höglund, Torben Steiniche, Karin Mogensen, Aurélien de Reyniès, Roman Nawroth, Brian Jordan, Xiaoqi Lin, Dejan Dragicevic, Douglas G. Ward, Anshita Goel, Carolyn D. Hurst, Jay D. Raman, Joshua I. Warrick, Ulrika Segersten, Danijel Sikic, Kim E. M. van Kessel, Tobias Maurer, Joshua J. Meeks, David J. DeGraff, Richard T. Bryan, Margaret A. Knowles, Tatjana Simic, Arndt Hartmann, Ellen C. Zwarthoff, Per-Uno Malmström, Núria Malats, Francisco X. Real, Lars Dyrskjøt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Multiple molecular profiling methods are required to study urothelial non-muscle-invasive bladder cancer (NMIBC) due to its heterogeneity. Here the authors integrate multi-omics data of 834 NMIBC patients, identifying a molecular subgroup associated
Externí odkaz:
https://doaj.org/article/25de5d15c38f4468b633c9e4bdca4e8d
Autor:
Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso, Oscar Lao, Esther Molina-Montes, Isabel Adoración Martín-Antoniano, Paulina Gómez-Rubio, Rita Lawlor, Alfredo Carrato, Manuel Hidalgo, Mar Iglesias, Xavier Molero, Matthias Löhr, Christopher Michalski, José Perea, Michael O’Rorke, Victor Manuel Barberà, Adonina Tardón, Antoni Farré, Luís Muñoz-Bellvís, Tanja Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Thomas Gress, William Greenhalf, Linda Sharp, Luís Arnes, Lluís Cecchini, Joaquim Balsells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Mirari Márquez, Josefina Mora, Damian O’Driscoll, Aldo Scarpa, Weimin Ye, Jingru Yu, PanGenEU Investigators, Montserrat García-Closas, Manolis Kogevinas, Nathaniel Rothman, Debra T Silverman, SBC/EPICURO Investigators, Demetrius Albanes, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Federico Canzian, Margaret Du, Steve Gallinger, J Michael Gaziano, Phyllis J Goodman, Marc Gunter, Loic LeMarchand, Donghui Li, Rachael E Neale, Ulrika Peters, Gloria M Petersen, Harvey A Risch, Maria José Sánchez, Xiao-Ou Shu, Mark D Thornquist, Kala Visvanathan, Wei Zheng, Stephen J Chanock, Douglas Easton, Brian M Wolpin, Rachael Z Stolzenberg-Solomon, Alison P Klein, Laufey T Amundadottir, Marc A Marti-Renom, Francisco X Real, Núria Malats
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic var
Externí odkaz:
https://doaj.org/article/fd82873a71df49c79bdc3dadb14c043b
Autor:
Gabriel Capellá, Francisco X Real, Marta Gil-Martin, Rocio Garcia-Carbonero, Rafael Moreno, Ramon Alemany, Martí Farrera-Sal, Ramon Salazar, Teresa Macarulla, Jaime Martinez de Villarreal, Natalia del Pozo, Carmen Guillén-Ponce, Miriam Bazan-Peregrino, Rafael Álvarez, Ana Mato-Berciano, Emma Blasi, Carmen Blasco, Manel Cascallo, Maria C Riesco-Martinez, Helena Verdaguer, Maria Victoria Maliandi, Silvia Torres-Manjon, Marcel Costa, Noemí Vidal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus intratumoral spread and facilitate chemotherapy and immune cells extravasation into
Externí odkaz:
https://doaj.org/article/f20744c4524742ac8290f86ad68345d4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Infidelity to cell fate occurs when differentiated cells lose their original identity and either revert to a more multipotent state or transdifferentiate into a different cell type, either within the same embryonic lineage or in an entirely different
Externí odkaz:
https://doaj.org/article/fcd242144c6d44caa733c5e01c4b254d
Autor:
Catarina P. Santos, Eleonora Lapi, Jaime Martínez de Villarreal, Laura Álvaro-Espinosa, Asunción Fernández-Barral, Antonio Barbáchano, Orlando Domínguez, Ashley M. Laughney, Diego Megías, Alberto Muñoz, Francisco X. Real
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The biology of the urothelium has been difficult to study given the lack of methods to propagate these cells. Here, the authors generate mouse urothelial organoids derived from bladder urothelial cells with high CD49f/ITGA6 and define what regulates
Externí odkaz:
https://doaj.org/article/320d107785b94de1b92b9124a3eed2a2
Autor:
Miriam Marqués, Sonia Corral, María Sánchez-Díaz, Natalia del Pozo, Jaime Martínez de Villarreal, Norbert Schweifer, Ivana Zagorac, Frank Hilberg, Francisco X. Real
Publikováno v:
Molecular Cancer Therapeutics. 22:616-629
Bladder cancer is a highly prevalent tumor, requiring the urgent development of novel therapies, especially for locally advanced and metastatic disease. Nintedanib is a potent antifibrotic angio-kinase inhibitor, which has shown clinical efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b4d9f8c3fb9a6013c4f08c2e0a5daa
https://doi.org/10.1158/1535-7163.mct-21-0667
https://doi.org/10.1158/1535-7163.mct-21-0667