Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francisco Sadras"'
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells
Autor:
Choon Leng So, Mélanie Robitaille, Francisco Sadras, Michael H. McCullough, Michael J. G. Milevskiy, Geoffrey J. Goodhill, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Differences in shape can be a distinguishing feature between different cell types, but the shape of a cell can also be dynamic. Changes in cell shape are critical when cancer cells escape from the primary tumor and undergo major morphologica
Externí odkaz:
https://doaj.org/article/d73be88b33ce498590a3f9946c02f12e
Autor:
Mélanie Robitaille, Shao Ming Chan, Amelia A. Peters, Limin Dai, Choon Leng So, Alice H. L. Bong, Francisco Sadras, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5867 (2022)
A remodeling of calcium homeostasis, including calcium influx via store-operated calcium entry (SOCE), is a feature of breast cancers. SOCE is critical to maintain calcium balance in the endoplasmic reticulum calcium store and is an important mechani
Externí odkaz:
https://doaj.org/article/9c9d03408e4447319133159a8d31556a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11366 (2021)
Tumors exist in a complex milieu where interaction with their associated microenvironment significantly contributes to disease progression. Cancer-associated fibroblasts (CAFs) are the primary component of the tumor microenvironment and participate i
Externí odkaz:
https://doaj.org/article/de8669d7f8784713aadf9d165713beaf
Autor:
Francisco Sadras, Teneale A. Stewart, Mélanie Robitaille, Amelia A. Peters, Priyakshi Kalita-de Croft, Patsy S. Soon, Jodi M. Saunus, Sunil R. Lakhani, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 680 (2021)
Cancer-associated fibroblasts (CAFs) represent an important component of the tumour microenvironment and are implicated in disease progression. Two outstanding questions in cancer biology are how CAFs arise and how they might be targeted therapeutica
Externí odkaz:
https://doaj.org/article/8345c56fb6594f5e944735b38dfda3a5
Autor:
Alice H. Bong, Krystyna A. Gieniec, Francisco Sadras, Mélanie Robitaille, Sarah J. Roberts-Thomson, Felicity M. Davis, Gregory R. Monteith
Publikováno v:
Cancer Research. 83:3629-3629
Calcium is a key regulator of a variety of pathways important in breast cancer progression, including those involved in cell proliferation and invasiveness. Calcium signaling is implicated in processes relevant to the breast cancer tumor microenviron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad277e97f356814c512667ff743c515
https://doi.org/10.1158/1538-7445.am2023-3629
https://doi.org/10.1158/1538-7445.am2023-3629
Autor:
John J. Bassett, Mélanie Robitaille, Amelia A. Peters, Alice H. L. Bong, Meng‐Wong Taing, Ian A. Wood, Francisco Sadras, Sarah J. Roberts‐Thomson, Gregory R. Monteith
Publikováno v:
The FASEB Journal. 36
Excessive rapid increases in cytosolic free Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff1dd3e6899774a0d92944750216d72
https://doi.org/10.1096/fj.202002031rr
https://doi.org/10.1096/fj.202002031rr
Autor:
Sunil R. Lakhani, Jodi M. Saunus, Priyakshi Kalita-de Croft, Mélanie Robitaille, Sarah J. Roberts-Thomson, Patsy S. Soon, Gregory R. Monteith, Teneale A. Stewart, Francisco Sadras, Amelia A. Peters
Publikováno v:
Biomedicines
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 680, p 680 (2021)
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 680, p 680 (2021)
Cancer-associated fibroblasts (CAFs) represent an important component of the tumour microenvironment and are implicated in disease progression. Two outstanding questions in cancer biology are how CAFs arise and how they might be targeted therapeutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e674118920d1425a9de8edd088c099b
http://europepmc.org/articles/PMC8234491
http://europepmc.org/articles/PMC8234491
Autor:
Andrew J. Dalley, Johnathon J. Bassett, Silke B. Chalmers, Sarah J. Roberts-Thomson, P Kalita-de Croft, Francisco Sadras, Jodi M. Saunus, Gregory R. Monteith
Publikováno v:
Cancer Research. 79:P1-19
Background. Breast cancer brain metastases (BCBM) represents a terminal diagnosis accompanied by neurological decline and diminished quality of life. Average survival is less than a year following detection of neural lesions, due in part to an absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::199f172bafdaafb78a858e2797e1a01a
https://doi.org/10.1158/1538-7445.sabcs18-p1-19-05
https://doi.org/10.1158/1538-7445.sabcs18-p1-19-05
Autor:
Gregory R. Monteith, Sunil R. Lakhani, Sarah J. Roberts-Thomson, Amelia A. Peters, Jodi M. Saunus, Francisco Sadras, Patsy S. Soon, Teneale A. Stewart, Priyakshi Kalita-de Croft, Mélanie Robitaille
Publikováno v:
Cancer Research. 80:P6-06
Disruption of Ca2+ signaling during breast cancer tumorigenesis is now well-established. Despite the increasing recognition of the role of the tumour microenvironment, and cancer associated fibroblasts (CAFs), in tumorigenesis, very few studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a8af48883855620d3d40c5f5c3251c
https://doi.org/10.1158/1538-7445.sabcs19-p6-06-15
https://doi.org/10.1158/1538-7445.sabcs19-p6-06-15
Autor:
Patsy S. Soon, Teneale A. Stewart, Sunil R. Lakhani, Greg Monteith, Francisco Sadras, Jodi M. Saunus, Sarah J. Roberts-Thomson, Priyakshi Kalita-de Croft, Mélanie Robitaille
Publikováno v:
Cancer Research. 79:99-99
Calcium (Ca2+) influx pathways are remodelled in a variety of disease states, and alterations in the expression of specific Ca2+ permeable ion channels are a feature of some breast cancer subtypes. However, no studies have yet assessed possible alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dc76e9f2c0a495afb74afee0d41053f
https://doi.org/10.1158/1538-7445.am2019-99
https://doi.org/10.1158/1538-7445.am2019-99