Molecular Characterization of Lys49 and Asp49 Phospholipases A2 from Snake Venom and Their Antiviral Activities against Dengue virus

Autor: Andre L. Fuly, Johannes A. Eble, Eladio F. Sanchez, Maria I. Estevão-Costa, Valeria G. Alvarenga, Francisco S. Schneider, Gustavo B. Naumann, Michael Richardson, Raiana A. De Oliveira, Arthur S. B. Santos, Sergio Caldas, Alzira B. Cecilio

Publikováno v: Toxins, Vol 5, Iss 10, Pp 1780-1798 (2013)

We report the detailed molecular characterization of two PLA2s, Lys49 and Asp49 isolated from Bothrops leucurus venom, and examined their effects against Dengue virus (DENV). The Bl-PLA2s, named BlK-PLA2 and BlD-PLA2, are composed of 121 and 122 amin

Externí odkaz: https://doaj.org/article/6794dc11e3dd43eaad5368dfd7588d3c

Induction of neutralizing antibodies against mutalysin-II from Lachesis muta muta Snake Venom Elicited by a conformational B-cell epitope predicted by Blue Star Sting data base

Autor: Stephanie Stransky, Daysiane de Oliveira, Goran Neshich, Francisco Santos Schneider, Ricardo Andrez Machado-de-Ávila, Ana Flor-Sá, Carlos Chávez-Olórtegui, Mariana Velloso

Publikováno v: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA
Immunome Research
Immunome Research, BioMed Central, 2014, 11 (1), ⟨10.4172/1745-7580.1000083⟩

Mutalysin-II, from Lachesis muta muta snake venom, is an endopeptidase with hemorrhagic activity. To identify a conformational epitope we used Blue Star Sting, the latest version of the web based Sting Millenium Suite, as alternative computational an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee00310a0266f203326a400de46d5a7
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1032210