Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Francisco Ramírez-Valle"'
Autor:
Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-15 (2022)
Abstract Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibit
Externí odkaz:
https://doaj.org/article/bbdb650c3cdc4da7b9496d707ec64951
Autor:
Rajula Gaur, Kofi A. Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Dorota Cedzik, Jamie Connarn, Michael Thomas, Gerald Horan, Peter Schafer, Stuart Mair, Maria Palmisano, Francisco Ramírez-Valle
Publikováno v:
Arthritis researchtherapy. 24(1)
Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 is a novel, irreversible, covalent MK2 inhibitor under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef050bcc3ca5fcaf6872e84b4faeab30
https://pubmed.ncbi.nlm.nih.gov/35982464
https://pubmed.ncbi.nlm.nih.gov/35982464
Autor:
Oday Salman, Lei Zhao, Jordana B. Cohen, Marie Joe Dib, Joe David Azzo, Sushrima Gan, A. Mark Richards, Bianca Pourmussa, Rob Doughty, Ali Javaheri, Douglas L. Mann, Ernst Rietzschel, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Vanessa van Empel, Karl Kammerhoff, Joseph Maranville, Joseph Gogain, Jaclyn Dennis, Peter H. Schafer, Dietmar Seiffert, David A. Gordon, Francisco Ramirez‐Valle, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Kidney disease is common in heart failure with preserved ejection fraction (HFpEF). However, the biologic correlates and prognostic significance of kidney injury (KI), in HFpEF, beyond the estimated glomerular filtration rate (eGFR), are u
Externí odkaz:
https://doaj.org/article/005acfdc8a4844deafa49b506123ac19
Autor:
Oday Salman, Payman Zamani, Lei Zhao, Marie Joe Dib, Sushrima Gan, Joe David Azzo, Bianca Pourmussa, Arthur Mark Richards, Ali Javaheri, Douglas L. Mann, Ernst Rietzschel, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Laura Liu, Kushan L. Gunawardhana, Danielle Greenawalt, Leon Carayannopoulos, Ching‐Pin Chang, Vanessa van Empel, Joseph Gogain, Peter H. Schafer, David A. Gordon, Francisco Ramirez‐Valle, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the prognostic significance and biologic p
Externí odkaz:
https://doaj.org/article/9ce69a1294c446d9a935a66c5df06d36
Autor:
Abhishek Dattani, Emer M. Brady, Prathap Kanagala, Svetlana Stoma, Kelly S. Parke, Anna-Marie Marsh, Anvesha Singh, Jayanth R. Arnold, Alastair J. Moss, Lei Zhao, Mary Ellen Cvijic, Matthew Fronheiser, Shuyan Du, Philippe Costet, Peter Schafer, Leon Carayannopoulos, Ching-Pin Chang, David Gordon, Francisco Ramirez-Valle, Michael Jerosch-Herold, Christopher P. Nelson, Iain B. Squire, Leong L. Ng, Gaurav S. Gulsin, Gerry P. McCann
Publikováno v:
BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) frequently co-exist. There is a limited understanding on whether this coexistence is associated with distinct alterations in myocardial remodellin
Externí odkaz:
https://doaj.org/article/4215841e5eec4d4b893e3592affdca59
Autor:
Corinne Carland, Lei Zhao, Oday Salman, Jordana B. Cohen, Payman Zamani, Qing Xiao, Ashok Dongre, Zhaoqing Wang, Christina Ebert, Danielle Greenawalt, Vanessa van Empel, A. Mark Richards, Robert N. Doughty, Ernst Rietzschel, Ali Javaheri, Yixin Wang, Peter H. Schafer, Sarah Hersey, Leonidas N. Carayannopoulos, Dietmar Seiffert, Ching‐Pin Chang, David A. Gordon, Francisco Ramirez‐Valle, Douglas L. Mann, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 9 (2024)
Background Although several studies have addressed plasma proteomics in heart failure with preserved ejection fraction, limited data are available on the prognostic value of urinary proteomics. The objective of our study was to identify urinary prote
Externí odkaz:
https://doaj.org/article/31d03371ea994940952d131d3a850e78
Autor:
Maria Palmisano, Kenichi Takeshita, Judith I. Ventura, Olivier Gouedard, Simon Zhou, Yongjun Xue, Yan Li, Francisco Ramírez-Valle, Jay Mei
Publikováno v:
The Journal of Clinical Pharmacology. 57:1279-1289
CC-292, a potent Bruton tyrosine kinase inhibitor, is under development for the treatment of B-cell malignancies. An analysis was performed to develop a population pharmacokinetic model of CC-292 and assess the influence of demographics and disease-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a085467a9b28c6a8bc3bd5b9c7af393
https://doi.org/10.1002/jcph.923
https://doi.org/10.1002/jcph.923
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 216, iss 7
The Journal of experimental medicine, vol 216, iss 7
Tissue residence of motile lymphocytes depends on systems that counteract egress-promoting cues. Laidlaw et al. find that the migration inhibitory S1PR2 receptor cooperates with CD69 to promote the retention of IL-17–producing γδ T cells within t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb3a45389becf2a0873625bf8bf874e
https://pubmed.ncbi.nlm.nih.gov/31160320
https://pubmed.ncbi.nlm.nih.gov/31160320
Autor:
Marie‐Joe Dib, Michael G. Levin, Lei Zhao, Ahmed Diab, Zhaoqing Wang, Christina Ebert, Oday Salman, Joe David Azzo, Sushrima Gan, Payman Zamani, Jordana B. Cohen, Dipender Gill, Stephen Burgess, Loukas Zagkos, Vanessa van Empel, A. Mark Richards, Rob Doughty, Ernst R. Rietzschel, Karl Kammerhoff, Erika Kvikstad, Joseph Maranville, Peter Schafer, Dietmar A. Seiffert, Francisco Ramirez‐Valle, David A. Gordon, Ching‐Pin Chang, Ali Javaheri, Douglas L. Mann, Thomas P. Cappola, Julio A. Chirinos
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 5 (2024)
Background Identifying novel molecular drivers of disease progression in heart failure (HF) is a high‐priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma prote
Externí odkaz:
https://doaj.org/article/5a885cf45ed64ca0bb38fb1fc18ac373
Autor:
Kathleen Coggshall, Timothy G. Berger, Joanna Harp, Beth S. Ruben, Francisco Ramírez-Valle, Steven Y. He
Publikováno v:
International Journal of Dermatology. 54:617-625
Importance Cutaneous granulomas without an identifiable infectious etiology are a rare manifestation of primary immunodeficiency (ID). These cutaneous lesions can be misdiagnosed, often as sarcoidosis, when the skin findings precede the diagnosis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4bfdf9a601e9959288a84f1f4b50d59
https://doi.org/10.1111/ijd.12765
https://doi.org/10.1111/ijd.12765