Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Francisco R. Nieto"'
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 290 (2024)
Fucoidan is a polymer of L-fucose and L-fucose-4-sulphate naturally found in marine sources that inhibits p-selectin, preventing neutrophil recruitment to the site of injury. Fucoidan is employed in many studies as a tool to investigate the contribut
Externí odkaz:
https://doaj.org/article/77e04f26bfab4a24b832ac08c4a945fd
Autor:
Miguel Ángel Huerta, Carlos Gómez-Navas, Antonia Artacho-Cordón, Rafael González-Cano, Enrique J. Cobos, Francisco R. Nieto
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S689- (2023)
Externí odkaz:
https://doaj.org/article/355e21dacec8404a9a92e1b46d01ea07
Publikováno v:
Marine Drugs, Vol 21, Iss 5, p 316 (2023)
The pharmacological treatment of cancer-related pain is unsatisfactory. Tetrodotoxin (TTX) has shown analgesia in preclinical models and clinical trials, but its clinical efficacy and safety have not been quantified. For this reason, our aim was to p
Externí odkaz:
https://doaj.org/article/bedd08e0bdef495db0c5ae51779b2e2c
Autor:
Julia Jiménez-López, Inmaculada Bravo-Caparrós, Laura Cabeza, Francisco R. Nieto, Raúl Ortiz, Gloria Perazzoli, Eduardo Fernández-Segura, Francisco J. Cañizares, José M. Baeyens, Consolación Melguizo, José Prados
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 133, Iss , Pp 111059- (2021)
Paclitaxel (PTX), a drug widely used in lung cancer, has serious limitations including the development of peripheral neurotoxicity, which may lead to treatment discontinuation and therapy failure. The transport of PTX in large cationic liposomes coul
Externí odkaz:
https://doaj.org/article/236368c1584d4edca01b4d1234d16bd1
Autor:
Enrique J. Cobos, Chelsea A. Nickerson, Fuying Gao, Vijayendran Chandran, Inmaculada Bravo-Caparrós, Rafael González-Cano, Priscilla Riva, Nick A. Andrews, Alban Latremoliere, Corey R. Seehus, Gloria Perazzoli, Francisco R. Nieto, Nicole Joller, Michio W. Painter, Chi Him Eddie Ma, Takao Omura, Elissa J. Chesler, Daniel H. Geschwind, Giovanni Coppola, Manu Rangachari, Clifford J. Woolf, Michael Costigan
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1301-1312 (2018)
Summary: Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold h
Externí odkaz:
https://doaj.org/article/13a9fb8f80d74f569011eeba624c7454
Autor:
Rafael González-Cano, M. Carmen Ruiz-Cantero, Miriam Santos-Caballero, Carlos Gómez-Navas, Miguel Á. Tejada, Francisco R. Nieto
Publikováno v:
Toxins, Vol 13, Iss 7, p 483 (2021)
Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically classified as TTX-sensitive or TTX-resistant channels. VGSCs play a k
Externí odkaz:
https://doaj.org/article/59a75b3ad9b24fcbb6f21bfb014343fb
Autor:
Beatrice Oehler, Katrin Kistner, Corinna Martin, Jürgen Schiller, Rafaela Mayer, Milad Mohammadi, Reine-Solange Sauer, Milos R. Filipovic, Francisco R. Nieto, Jan Kloka, Diana Pflücke, Kerstin Hill, Michael Schaefer, Marzia Malcangio, Peter W. Reeh, Alexander Brack, Robert Blum, Heike L. Rittner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-22 (2017)
Abstract Phospholipids occurring in cell membranes and lipoproteins are converted into oxidized phospholipids (OxPL) by oxidative stress promoting atherosclerotic plaque formation. Here, OxPL were characterized as novel targets in acute and chronic i
Externí odkaz:
https://doaj.org/article/a6c20966bd864799baf52d5a980c648e
Autor:
Luca Blicker, Rafael González-Cano, Erik Laurini, Francisco R. Nieto, Judith Schmidt, Dirk Schepmann, Sabrina Pricl, Bernhard Wünsch
Publikováno v:
Journal of Medicinal Chemistry. 66:4999-5020
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b09d055e21fb5a9e18c7fd6b78049da
https://doi.org/10.1021/acs.jmedchem.2c02081
https://doi.org/10.1021/acs.jmedchem.2c02081
Autor:
M. Carmen Ruiz-Cantero, Carlos Gómez-Navas, Rafael González-Cano, Miguel Á. Tejada, Francisco R. Nieto, Miriam Santos-Caballero
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Toxins
Toxins, Vol 13, Iss 483, p 483 (2021)
instname
Toxins
Toxins, Vol 13, Iss 483, p 483 (2021)
This publication was partially supported by grant CTS 109 from the Junta de Andalucia, grant INTRAIBS-2020-09 from Biosanitary Research Institute ibs.GRANADA, and grant PPJIA2020-06 from the University of Granada.
Tetrodotoxin (TTX) is a potent
Tetrodotoxin (TTX) is a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450febaf6ef3bd4425cc645c5b6f7964
https://www.mdpi.com/2072-6651/13/7/483/pdf?version=1626583474
https://www.mdpi.com/2072-6651/13/7/483/pdf?version=1626583474
Autor:
Marta Pujol, Francisco R. Nieto, Eva Ayet, Bernhard Wünsch, Simone Thum, Simon M. Ametamey, Dirk Schepmann
Publikováno v:
European Journal of Medicinal Chemistry. 177:47-62
The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of the 4-phenylbutyl side chain in 3-position. Ligands with the F-atom in γ-position possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9363ed2e487270d664572d1358e3b81c
https://doi.org/10.1016/j.ejmech.2019.05.034
https://doi.org/10.1016/j.ejmech.2019.05.034