Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Francisco R. Portell"'
Autor:
Francisco R. Portell, Patrick F. Antkowiak, James P. Bennett, Paula M. Keeney, Bijoy Kundu, Meiram Zh. Shakenov, Nicholas J. Tustison, Amy C. Ladd, Ravindar R. Thomas, David G. Brohawn, Stuart S. Berr, Shaharyar M. Khan
Publikováno v:
Brain Research. 1667:74-83
Amyotrophic lateral sclerosis (ALS) is a generally fatal neurodegenerative disease of adults that produces weakness and atrophy due to dysfunction and death of upper and lower motor neurons. We used RNA-sequencing (RNA-seq) to analyze expression of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8436daba6f23cbb2e6ebaff381fcf2
https://doi.org/10.1016/j.brainres.2017.05.010
https://doi.org/10.1016/j.brainres.2017.05.010
Autor:
Rebecca Caffrey, Shaharyar M. Khan, Francisco R. Portell, Arun J. Sanyal, Jameel Dennis, Stephen Eaton, Omer M Khan, Jonathon Marioneaux, Isaac G. Onyango
Publikováno v:
Journal of Hepatology. 70:e544
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf1aae778d6748627aa5ae1e284c828
https://doi.org/10.1016/s0618-8278(19)31077-1
https://doi.org/10.1016/s0618-8278(19)31077-1
Autor:
Ravindar R. Thomas, James P. Bennett, Francisco R. Portell, Shaharyar M. Khan, Rafal M. Smigrodzki
Publikováno v:
Mitochondrion. 11:108-118
Recombinant human mitochondrial transcription factor A protein (rhTFAM) was evaluated for its acute effects on cultured cells and chronic effects in mice. Fibroblasts incubated with rhTFAM acutely increased respiration in a chloramphenicol-sensitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5ffd71e27292bfba810eedbfbc20a8
https://doi.org/10.1016/j.mito.2010.08.004
https://doi.org/10.1016/j.mito.2010.08.004
Autor:
Francisco R. Portell, Isaac G. Onyango, S. Eaton, Archana Sanyal, Jameel Dennis, P. Bedossa, Omer M Khan, Rebecca Caffrey, Shaharyar M. Khan, Prasanna K. Santhekadur, Jonathon Marioneaux
Publikováno v:
Journal of Hepatology. 68:S579
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e51634c3c05d8f517f0e92fe30ea9b
https://doi.org/10.1016/s0168-8278(18)31417-x
https://doi.org/10.1016/s0168-8278(18)31417-x
Autor:
Kristen E. Bergquist, Kathleen M. Schwarz, Patricia A. Trimmer, Shilpa Iyer, Ravindar R. Thomas, Christina M. Papageorge, James P. Bennett, Shaharyar M. Khan, Lisa D. Dunham, Caitlin K. Quigley, Paula M. Keeney, Francisco R. Portell
Publikováno v:
Human Gene Therapy. 20:897-907
Neurodegeneration in Parkinson's disease (PD) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose detectable respiratory activity associated with depletion of intact mitochondrial DNA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550675f8d4111707ff0569aa964c0aa6
https://doi.org/10.1089/hum.2009.023
https://doi.org/10.1089/hum.2009.023
Autor:
Shilpa Iyer, James P. Bennett, Lisa D. Dunham, Ravindar R. Thomas, Francisco R. Portell, Caitlin K. Quigley
Publikováno v:
Mitochondrion. 9:196-203
We developed a scalable procedure to produce human mitochondrial transcription factor A (TFAM) modified with an N-terminal protein transduction domain (PTD) and mitochondrial localization signal (MLS) that allow it to cross membranes and enter mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cbdc2b1a3b596298d15a36023d9863
https://doi.org/10.1016/j.mito.2009.01.012
https://doi.org/10.1016/j.mito.2009.01.012
Publikováno v:
The Future of Aging ISBN: 9789048139989
The mitochondrial theory of aging states that the accumulation of damage to the mitochondrial genome is an important contributing factor to aging. In this review we analyze evidence in favor of this theory and consider the biochemical mechanisms that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2919d176637c8579154e49d87076fc2e
https://doi.org/10.1007/978-90-481-3999-6_16
https://doi.org/10.1007/978-90-481-3999-6_16
Autor:
Lisa Dunahm, Ravindar R. Thomas, Shilpa Iyer, James Bennett, Caitlin K. Quigley, Francisco R. Portell
Publikováno v:
Nature Precedings.
Diseases involving mitochondrial defects usually manifest themselves in high-energy, post-mitotic tissues such as brain, retina, skeletal and cardiac muscle and frequently cause deficiencies in mitochondrial bioenergetics. We have developed a scalabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84983cb0e6e6a461ba8fe3d35d33bb4d
https://doi.org/10.1038/npre.2008.2084.1
https://doi.org/10.1038/npre.2008.2084.1
Autor:
Shilpa Iyer, Ravindar R. Thomas, Francisco R. Portell, Lisa D. Dunahm, Caitlin K. Quigley, James P. Bennett
Publikováno v:
Nature Precedings
Diseases involving mitochondrial defects usually manifest themselves in high-energy, post-mitotic tissues such as brain, retina, skeletal and cardiac muscle and frequently cause deficiencies in mitochondrial bioenergetics. We have developed a scalabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______984::f2540e8bc54a1b03dbe7f2f99caafc3e
http://precedings.nature.com/documents/2084/version/1
http://precedings.nature.com/documents/2084/version/1
Autor:
Shilpa Iyer, Francisco R. Portell, James P. Bennett, Lisa D. Dunham, Charles R. Arthur, Bradley Miller, Shaharyar M. Khan, Kristen E. Berquist, Kisha J. Young
Publikováno v:
Mitochondrion. 11:643
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6f016ef233d0e117670ecd8874230b0
https://doi.org/10.1016/j.mito.2011.03.028
https://doi.org/10.1016/j.mito.2011.03.028