Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Francisco Q."'
Autor:
Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, Joana M. Marques
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. T
Externí odkaz:
https://doaj.org/article/eb8f8fcddb564941b72eac2840610363
Autor:
Mara Yone D. Fernandes, Fernando Dobrachinski, Henrique B. Silva, João Pedro Lopes, Francisco Q. Gonçalves, Felix A. A. Soares, Lisiane O. Porciúncula, Geanne M. Andrade, Rodrigo A. Cunha, Angelo R. Tomé
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction und
Externí odkaz:
https://doaj.org/article/e4562b728f2f4c6e95a8ba831eba7f7f
Autor:
Cátia R. Lopes, Francisco Q. Gonçalves, Simão Olaio, Angelo R. Tomé, Rodrigo A. Cunha, João Pedro Lopes
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 715 (2023)
Adenosine operates a modulation system fine-tuning the efficiency of synaptic transmission and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal activation of A1R can block hippocampal synaptic transmission, and the toni
Externí odkaz:
https://doaj.org/article/6b8ee4d65d7d40ecbf835020758a6a6a
Autor:
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105441- (2021)
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A
Externí odkaz:
https://doaj.org/article/218cea5ef5a84400aaea77837c4e90ac
Autor:
Liliana Dias, Cátia R. Lopes, Francisco Q. Gonçalves, Ana Nunes, Daniela Pochmann, Nuno J. Machado, Angelo R. Tomé, Paula Agostinho, Rodrigo A. Cunha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications
Externí odkaz:
https://doaj.org/article/91c658f68075479683e3ae34069f7cb4
Autor:
Ana Moreira-de-Sá, Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Ângelo R. Tomé, Rodrigo A. Cunha, Paula M. Canas
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105137- (2020)
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of function of the maternally inherited Ube3a neuronal protein, whose main features comprise severe intellectual disabilities and motor impairments. Previous studies with the Ube3
Externí odkaz:
https://doaj.org/article/b59b852f614d4665b6515b9ec4f33605
Autor:
António C. Silva, Cristina Lemos, Francisco Q. Gonçalves, Anna V. Pliássova, Nuno J. Machado, Henrique B. Silva, Paula M. Canas, Rodrigo A. Cunha, João Pedro Lopes, Paula Agostinho
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 72-81 (2018)
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A2A receptors (A2AR) are mostly located in synapses controlling synaptic plasticity. The over-activation of adenosine A2A receptors (A2AR) causes memory deficits and th
Externí odkaz:
https://doaj.org/article/7eac53947721403c9a17b334ba8169ed
Autor:
Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Cristina Lemos, António C. Silva, Nélio Gonçalves, Ângelo R. Tomé, Samira G. Ferreira, Paula M. Canas, Daniel Rial, Paula Agostinho, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Adenosine A2A receptors (A2AR) overfunction causes synaptic and memory dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ1-42)-based model of early AD, we now unraveled that this involves an increased synaptic release of ATP coupled
Externí odkaz:
https://doaj.org/article/5afe45d9cdb74873aa61a2ff27b5edf9
Autor:
Silvia Viana da Silva, Matthias Georg Haberl, Pei Zhang, Philipp Bethge, Cristina Lemos, Nélio Gonçalves, Adam Gorlewicz, Meryl Malezieux, Francisco Q. Gonçalves, Noëlle Grosjean, Christophe Blanchet, Andreas Frick, U Valentin Nägerl, Rodrigo A. Cunha, Christophe Mulle
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memo
Externí odkaz:
https://doaj.org/article/1ea75979789f4071b6f94deca86c19df
Autor:
Ana C. Rodrigues-Neves, Inês D. Aires, Joana Vindeirinho, Raquel Boia, Maria H. Madeira, Francisco Q. Gonçalves, Rodrigo A. Cunha, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Glaucoma is the second cause of blindness worldwide and is characterized by the degeneration of retinal ganglion cells (RGCs) and optic nerve atrophy. Increased microglia reactivity is an early event in glaucoma that may precede the loss of RGCs, sug
Externí odkaz:
https://doaj.org/article/e1013c2257574b70aa5c057e8c7f63db