Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Francisco Q Gonçalves"'
Autor:
Daniel eRial, Cristina eLemos, Helena ePinheiro, Joana M Duarte, Francisco Q Gonçalves, Joana Isabel Real, Rui Daniel Prediger, Nélio eGonçalves, Catarina A. Gomes, Paula M Canas, Paula eAgostinho, Rodrigo A Cunha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2016)
Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processing occurring in defined frontolimbic circuits responsible for emotional process
Externí odkaz:
https://doaj.org/article/15e34705fce34fb1bbde9075e38970a7
Autor:
Daniel Rial, Adalberto A Castro, Nuno Machado, Pedro Garção, Francisco Q Gonçalves, Henrique B Silva, Angelo R Tomé, Attila Köfalvi, Olga Corti, Rita Raisman-Vozari, Rodrigo A Cunha, Rui D Prediger
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114216 (2014)
There is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits
Externí odkaz:
https://doaj.org/article/10c793ab9b5c4cbf87c977c86e3d079a
Autor:
Mara Yone D. Fernandes, Fernando Dobrachinski, Henrique B. Silva, João Pedro Lopes, Francisco Q. Gonçalves, Felix A. A. Soares, Lisiane O. Porciúncula, Geanne M. Andrade, Rodrigo A. Cunha, Angelo R. Tomé
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A2A receptors, which can control synaptic dysfunction und
Externí odkaz:
https://doaj.org/article/e4562b728f2f4c6e95a8ba831eba7f7f
Autor:
Cátia R. Lopes, Francisco Q. Gonçalves, Simão Olaio, Angelo R. Tomé, Rodrigo A. Cunha, João Pedro Lopes
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 715 (2023)
Adenosine operates a modulation system fine-tuning the efficiency of synaptic transmission and plasticity through A1 and A2A receptors (A1R, A2AR), respectively. Supramaximal activation of A1R can block hippocampal synaptic transmission, and the toni
Externí odkaz:
https://doaj.org/article/6b8ee4d65d7d40ecbf835020758a6a6a
Autor:
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105441- (2021)
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A
Externí odkaz:
https://doaj.org/article/218cea5ef5a84400aaea77837c4e90ac
Autor:
Liliana Dias, Cátia R. Lopes, Francisco Q. Gonçalves, Ana Nunes, Daniela Pochmann, Nuno J. Machado, Angelo R. Tomé, Paula Agostinho, Rodrigo A. Cunha
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Depressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications
Externí odkaz:
https://doaj.org/article/91c658f68075479683e3ae34069f7cb4
Autor:
Liliana Dias, Daniela Pochmann, Cristina Lemos, Henrique B. Silva, Joana I. Real, Francisco Q. Gonçalves, Daniel Rial, Nélio Gonçalves, Ana Patrícia Simões, Samira G. Ferreira, Paula Agostinho, Rodrigo A. Cunha, Angelo R. Tomé
Publikováno v:
ACS Chemical Neuroscience. 14:1299-1309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f4301063c748fa6d021ef96fe577a3
https://doi.org/10.1021/acschemneuro.2c00810
https://doi.org/10.1021/acschemneuro.2c00810
Autor:
Ana Moreira-de-Sá, Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Ângelo R. Tomé, Rodrigo A. Cunha, Paula M. Canas
Publikováno v:
Neurobiology of Disease, Vol 146, Iss , Pp 105137- (2020)
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of function of the maternally inherited Ube3a neuronal protein, whose main features comprise severe intellectual disabilities and motor impairments. Previous studies with the Ube3
Externí odkaz:
https://doaj.org/article/b59b852f614d4665b6515b9ec4f33605
Autor:
António C. Silva, Cristina Lemos, Francisco Q. Gonçalves, Anna V. Pliássova, Nuno J. Machado, Henrique B. Silva, Paula M. Canas, Rodrigo A. Cunha, João Pedro Lopes, Paula Agostinho
Publikováno v:
Neurobiology of Disease, Vol 117, Iss , Pp 72-81 (2018)
Alzheimer's disease (AD) begins with a deficit of synaptic function and adenosine A2A receptors (A2AR) are mostly located in synapses controlling synaptic plasticity. The over-activation of adenosine A2A receptors (A2AR) causes memory deficits and th
Externí odkaz:
https://doaj.org/article/7eac53947721403c9a17b334ba8169ed
Autor:
Francisco Q. Gonçalves, Filipe C. Matheus, Henrique B. Silva, Joana I. Real, Daniel Rial, Ricardo J. Rodrigues, Jean-Pierre Oses, António C. Silva, Nélio Gonçalves, Rui D. Prediger, Ângelo R. Tomé, Rodrigo A. Cunha
Publikováno v:
Molecular Neurobiology. 60:1659-1674
Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson’s disease (PD) is unclear and was now investigated. ATP was particularly released at high stimulation intensities from purified striatal nerve termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af30f240f48859a31ff1f9ecd3db373
https://doi.org/10.1007/s12035-022-03162-1
https://doi.org/10.1007/s12035-022-03162-1