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Autor:
Catia M Pereira, Renato Filev, Francisco P Dubiela, Bruna B Brandão, Claudio M Queiroz, Raissa G Ludwig, Debora Hipolide, Beatriz M Longo, Luiz E Mello, Marcelo A Mori, Beatriz A Castilho
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217287 (2019)
IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT expression in neuronal cells increases basal GCN2 activation and eIF2α phosphorylation and dec
Externí odkaz:
https://doaj.org/article/0c0744d4f02a428ebfd2abb9baf2da26