Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Francisco Orallo"'
Autor:
Dolores Viña, Verónica García-Morales, Fernanda Borges, Gianni Podda, Lourdes Santana, Carmen Picciau, Giovanna Delogu, Elías Quezada, Francisco Orallo
Publikováno v:
Molecules, Vol 15, Iss 1, Pp 270-279 (2010)
A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta ri
Externí odkaz:
https://doaj.org/article/831806c517d1417bb987a5c56bc375ac
Autor:
Francisco Orallo, Alejandro Speck-Planche, Matilde Yáñez, Enrique Molina, Eduardo Sobarzo-Sánchez, Eugenio Uriarte, Lourdes Santana, Maria João Matos
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 12:947-958
With the significant increase of life expectancy of populations in societies today, the importance of the discovery of drugs associated with neurodegenerative diseases has emerged. Therefore, neurodegenerative diseases are an important topic in Medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b287db9c97bb6741e9440cdfb832b8c
https://doi.org/10.2174/138955712802762383
https://doi.org/10.2174/138955712802762383
Publikováno v:
Molecular Nutrition & Food Research. 55:1237-1248
Scope The aim of this study was to investigate whether the dietary polyphenol trans-resveratrol (t-Resv) increases [Ca(2+)](c) in endothelial cells, leading to a simultaneous augmentation of nitric oxide (NO) biosynthesis. Methods and results We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03083294f9f582e70b9d4892d0eb0f11
https://doi.org/10.1002/mnfr.201100240
https://doi.org/10.1002/mnfr.201100240
Autor:
Matilde Yáñez, Stefano Alcaro, Fedele Manna, Adriana Bolasco, Rossella Fioravanti, Francisco Orallo, Francesco Ortuso, Alberto Vitali, Francesca Rossi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6479-6482
A series of N-substituted-3-[(2′-hydroxy-4′-prenyloxy)-phenyl]-5-phenyl-4,5-dihydro-(1H)-pyrazolines were synthesized and tested on human monoamine oxidase-A and -B isoforms. Structure–activity relationships and molecular modelling showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a692515f69f79f007be700a3b8423b
https://doi.org/10.1016/j.bmcl.2010.09.061
https://doi.org/10.1016/j.bmcl.2010.09.061
Autor:
Alessandro Piras, Carmen Terán, Tamara Costas, Matilde Yáñez, Laura Acevedo, Reyes Laguna, Pedro Besada, Francisco Orallo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6624-6627
New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6456ee80bd8a0e84ea4ccac7d7a27bc7
https://doi.org/10.1016/j.bmcl.2010.09.031
https://doi.org/10.1016/j.bmcl.2010.09.031
Autor:
Elias Maccioni, Francisco Orallo, Matilde Yáñez, Daniela Secci, S. Vigo, Maria Luisa Sanna, Stefano Alcaro, Maria Cristina Cardia, Giosuè Costa, Simona Distinto, Rita Meleddu
Publikováno v:
European Journal of Medicinal Chemistry. 45:4490-4498
Some differently substituted 3-aryl-4,5-dihydropyrazoles-1-carbothioamides have been synthesised with the aim to investigate their monoamine oxidase inhibitory activity. The chemical structures of the compounds have been characterized by means of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6026e6575bc8ddba4abae60f3f4004
https://doi.org/10.1016/j.ejmech.2010.07.009
https://doi.org/10.1016/j.ejmech.2010.07.009
Autor:
Adriana Bolasco, M. Luisa Sanna, Roberto Cirilli, Paola Chimenti, Simone Carradori, Daniela Secci, Arianna Granese, Matilde Yáñez, Franco Chimenti, Bruno Gallinella, Francisco Orallo
Publikováno v:
Journal of Medicinal Chemistry. 53:6516-6520
Novel 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine derivatives have been investigated for their ability to inhibit selectively the activity of the human B isoform of monoamine oxidase. These compounds were obtained as racemates and (R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641493bcbeab5c018b353e760fe6a171
https://doi.org/10.1021/jm100120s
https://doi.org/10.1021/jm100120s
Autor:
Daniela Secci, Stefano Alcaro, Arianna Granese, Franco Chimenti, Adriana Bolasco, Paola Chimenti, Francisco Orallo, Francesco Ortuso, Matilde Yáñez, Simone Carradori
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:5715-5723
A new series of [4-(3-methoxyphenyl)-thiazol-2-yl]hydrazyne derivatives were synthesized in good yield (71-99%) and characterized by elemental analysis and 1H NMR studies. The compounds were assayed for their in vitro human monoamine oxidase (hMAO) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498c5605998ad0b52896b95a77e4b2d1
https://doi.org/10.1016/j.bmc.2010.06.007
https://doi.org/10.1016/j.bmc.2010.06.007
Autor:
Antonio G. García, J. M. Hernández-Guijo, Lorena Cortés, Jose Carlos Gonzalez, Matilde Yáñez, Francisco Orallo, José-Carlos Fernández-Morales, Antonio M. G. de Diego
Publikováno v:
Molecular Pharmacology. 78:734-744
The cardiovascular protecting effects of resveratrol, an antioxidant polyphenol present in grapes and wine, have been attributed to its vasorelaxing effects and to its anti-inflammatory, antioxidant, and antiplatelet actions. Inhibition of adrenal ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfe9647a57770956214726384caf420
https://doi.org/10.1124/mol.110.066423
https://doi.org/10.1124/mol.110.066423
Autor:
Francisco Orallo, Fernanda Borges, Nuno Milhazes, Alexandra Gaspar, Stefano Alcaro, Matilde Yáñez, Eugenio Uriarte, Francesco Ortuso
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Chromone carboxylic acids were evaluated as human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitors. The biological data indicated that only chromone-3-carboxylic acid is a potent hMAO-B inhibitor, with a high degree of selectivity for hMAO-B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e6121438ce4c2b3df07b92cfd46465
https://doi.org/10.1016/j.bmcl.2010.03.081
https://doi.org/10.1016/j.bmcl.2010.03.081