Morphologic study of the effect of iron on pseudocyst formation in Trichomonas vaginalis and its interaction with human epithelial cells

Autor: Geovane Dias-Lopes, Leonardo Saboia-Vahia, Eliane Trindade Margotti, Nilma de Souza Fernandes, Cássia Luana de Faria Castro, Francisco Odencio Oliveira Junior, Juliana Figueiredo Peixoto, Constança Britto, Fernando Costa e Silva Filho, Patricia Cuervo, José Batista de Jesus

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 112, Iss 10, Pp 664-673

BACKGROUND Trichomonas vaginalis is the aetiological agent of human trichomoniasis, which is one of the most prevalent sexually transmitted diseases in humans. Iron is an important element for the survival of this parasite and the colonisation of the

Externí odkaz: https://doaj.org/article/49e4d75e532d426aa22276bc2185a7d6

Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2′-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment

Autor: Luiz Filipe Gonçalves Oliveira, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Lea Cysne-Finkelstein, Mirian Cláudia de Souza Pereira, Francisco Odêncio de Oliveira Junior, Rosa Teixeira Pinho, Suzana Corte Real, Saulo Cabral Bourguignon, Vitor Francisco Ferreira, Carlos Roberto Alves

Publikováno v: Molecules, Vol 23, Iss 4, p 864 (2018)

Epoxymethoxylawsone is a naphthoquinone derivative promising as drug candidate for the treatment of leishmaniases. In the present work the effectiveness of epoxymethoxylawsone, and meglumine antimoniate on Leishmania (Leishmania) amazonensis parasite

Externí odkaz: https://doaj.org/article/4502ab2d90ec4628b4cfc9cd7ec8c061

Role of FAK signaling in chagasic cardiac hypertrophy

Autor: Liliane Batista de Mesquita, Gabriel Melo de Oliveira, Mirian Claudia de Souza Pereira, Amanda R. Tucci, Guilherme C. Lechuga, Priscila Silva Grijó Farani, Otacilio C. Moreira, Constança Britto, Ana Carolina Eleuterio, Francisco Odêncio Rodrigues de Oliveira

Publikováno v: Brazilian Journal of Infectious Diseases, Vol 24, Iss 5, Pp 386-397 (2020)
Brazilian Journal of Infectious Diseases v.24 n.5 2020
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Volume: 24, Issue: 5, Pages: 386-397, Published: 30 NOV 2020

Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ab0507aebede66cbfcac3c7ed71d41
http://www.sciencedirect.com/science/article/pii/S1413867020301227

Vector competence and feeding-excretion behavior of Triatoma rubrovaria (Blanchard, 1843) (Hemiptera: Reduviidae) infected with Trypanosoma cruzi TcVI

Autor: Jacenir Reis dos Santos Mallet, Thaiane Verly, Márcio G. Pavan, Stephanie Lyanie de Melo e Costa, Carlos José de Carvalho Moreira, Nathanielly Rocha Casado de Lima, Mirian Claudia de Souza Pereira, Francisco Odêncio, Constança Britto

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008712 (2020)
PLoS Neglected Tropical Diseases

Background Several studies addressed changes on the insect vector behavior due to parasite infection, but little is known for triatomine bugs, vectors of Trypanosoma cruzi, the etiological agent of Chagas disease. We assessed infection rates and meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8761bbe7f4258c07bf465bde96f887
https://doaj.org/article/4e0310967ade44c38a65549fcc27bbf2

Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease

Autor: Carlos Roberto Alves, Saulo Cabral Bourguignon, Francisco Odêncio Rodrigues de Oliveira, B.A. Souto, Guilherme C. Lechuga, Franklin Souza-Silva, M.G. Viganó, M.E. Monteiro, Maurício S. dos Santos, Leonardo da Silva Lara, Claudia M. Calvet, Mirian Claudia de Souza Pereira

Publikováno v: European journal of medicinal chemistry. 182

Drug therapy for Chagas disease remains a major challenge as potential candidate drugs have failed clinical trials. Currently available drugs have limited efficacy and induce serious side effects. Thus, the discovery of new drugs is urgently needed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc18d621ea5a11b2c645b87ac5b260e
https://pubmed.ncbi.nlm.nih.gov/31434040