Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Francisco N Barrera"'
Autor:
Yujie Ye, Shumpei Morita, Justin J Chang, Patrick M Buckley, Kiera B Wilhelm, Daniel DiMaio, Jay T Groves, Francisco N Barrera
Publikováno v:
eLife, Vol 12 (2023)
The T cell receptor (TCR) is a complex molecular machine that directs the activation of T cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of investigation, the molecular mechanism of TCR activation is still cont
Externí odkaz:
https://doaj.org/article/5bc68c83b835416d911a9631379addcc
Autor:
Charles M Russell, Katherine G Schaefer, Andrew Dixson, Amber LH Gray, Robert J Pyron, Daiane S Alves, Nicholas Moore, Elizabeth A Conley, Ryan J Schuck, Tommi A White, Thanh D Do, Gavin M King, Francisco N Barrera
Publikováno v:
eLife, Vol 11 (2022)
Candida albicans causes severe invasive candidiasis. C. albicans infection requires the virulence factor candidalysin (CL) which damages target cell membranes. However, the mechanism that CL uses to permeabilize membranes is unclear. We reveal that C
Externí odkaz:
https://doaj.org/article/79958a3cea334a74ad69da42c957104a
Autor:
Junyan Liu, Hubertine M E Willems, Emily A Sansevere, Stefanie Allert, Katherine S Barker, David J Lowes, Andrew C Dixson, Zhenbo Xu, Jian Miao, Christian DeJarnette, Helene Tournu, Glen E Palmer, Jonathan P Richardson, Francisco N Barrera, Bernhard Hube, Julian R Naglik, Brian M Peters
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009884 (2021)
Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, play
Externí odkaz:
https://doaj.org/article/b3e2ce06c5484147bdbc2ffbdee60a64
Autor:
Daiane S Alves, Justin M Westerfield, Xiaojun Shi, Vanessa P Nguyen, Katherine M Stefanski, Kristen R Booth, Soyeon Kim, Jennifer Morrell-Falvey, Bing-Cheng Wang, Steven M Abel, Adam W Smith, Francisco N Barrera
Publikováno v:
eLife, Vol 7 (2018)
Misregulation of the signaling axis formed by the receptor tyrosine kinase (RTK) EphA2 and its ligand, ephrinA1, causes aberrant cell-cell contacts that contribute to metastasis. Solid tumors are characterized by an acidic extracellular medium. We in
Externí odkaz:
https://doaj.org/article/c5d8558633184388971353fd6c908488
Autor:
Emily B Cohen, Susan J Jun, Zachary Bears, Francisco N Barrera, Miriam Alonso, Donald M Engelman, Daniel DiMaio
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95593 (2014)
Transmembrane proteins constitute a large fraction of cellular proteins, and specific interactions involving membrane-spanning protein segments play an important role in protein oligomerization, folding, and function. We previously isolated an artifi
Externí odkaz:
https://doaj.org/article/6cb29c609d404c259a8ce446f13f021c
Autor:
Christelle F. Ancajas, Shahrina Alam, Daiane S. Alves, Yue Zhou, Nicholas M. Wadsworth, Chelsi D. Cassilly, Tanei J. Ricks, Adam J. Carr, Todd B. Reynolds, Francisco N. Barrera, Michael D. Best
Publikováno v:
ACS Chemical Biology. 18:377-384
Autor:
William T. McClintic, Haden L. Scott, Nick Moore, Mustafa Farahat, Mikayla Maxwell, Catherine D. Schuman, Dima Bolmatov, Francisco N. Barrera, John Katsaras, C. Patrick Collier
Publikováno v:
MRS Bulletin. 48:13-21
Abstract In biology, heterosynaptic plasticity maintains homeostasis in synaptic inputs during associative learning and memory, and initiates long-term changes in synaptic strengths that nonspecifically modulate different synapse types. In bioinspire
Autor:
L. Palanikumar, Mona Kalmouni, Tatiana Houhou, Osama Abdullah, Liaqat Ali, Renu Pasricha, Sneha Thomas, Ahmed J. Afzal, Francisco N. Barrera, Mazin Magzoub
Publikováno v:
bioRxiv
Photodynamic therapy (PDT) and photothermal therapy (PTT) have garnered considerable interest as non-invasive cancer treatment modalities. However, these approaches remain limited by low solubility, poor stability and inefficient targeting of many co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd888381651ca6b38dca29e06aa9eef
https://doi.org/10.1101/2023.05.22.541491
https://doi.org/10.1101/2023.05.22.541491
Autor:
Jennifer A Rybak, Amita R Sahoo, Soyeon Kim, Robert J Pyron, Savannah B Pitts, Saffet Guleryuz, Adam W Smith, Matthias Buck, Francisco N Barrera
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anti-cancer therapeutics. Current therapeutics target EGFR’s kinase domain or extracellular region. However, these types of inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd98b103ef666c78304be4e4fbe2ff3
https://doi.org/10.1101/2022.10.31.514582
https://doi.org/10.1101/2022.10.31.514582
Autor:
Jennifer A. Rybak, Amita R. Sahoo, Soyeon Kim, Robert J. Pyron, Savannah B. Pitts, Adam W. Smith, Matthias Buck, Francisco N. Barrera
Publikováno v:
Biophysical Journal. 122:369a-370a