Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Francisco Meraz-Torres"'
Autor:
Francisco Meraz-Torres, Heike Niessner, Sarah Plöger, Simon Riel, Barbara Schörg, Nicolas Casadei, Manfred Kneilling, Martin Schaller, Lukas Flatz, Boris Macek, Thomas Eigentler, Olaf Rieß, Claus Garbe, Teresa Amaral, Tobias Sinnberg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus,
Externí odkaz:
https://doaj.org/article/35307e889f494a0d91d148dbfa645149
Autor:
Heike Niessner, Markus Burkard, Christian Leischner, Olga Renner, Sarah Plöger, Francisco Meraz-Torres, Matti Böcker, Constanze Hirn, Ulrich M. Lauer, Sascha Venturelli, Christian Busch, Tobias Sinnberg
Publikováno v:
Cells, Vol 11, Iss 7, p 1229 (2022)
High-dose ascorbate paradoxically acts as a pro-oxidant causing the formation of hydrogen peroxide in an oxygen dependent manner. Tumor cells (in particular melanoma cells) show an increased vulnerability to ascorbate induced reactive oxygen species
Externí odkaz:
https://doaj.org/article/ac50fc3fb9854c4399ee807731d5d2d5
Autor:
Tobias Sinnberg, Mitchell P. Levesque, Jelena Krochmann, Phil F. Cheng, Kristian Ikenberg, Francisco Meraz-Torres, Heike Niessner, Claus Garbe, Christian Busch
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-19 (2018)
Abstract Background During embryonic development Wnt family members and bone morphogenetic proteins (BMPs) cooperatively induce epithelial-mesenchymal transition (EMT) in the neural crest. Wnt and BMPs are reactivated during malignant transformation
Externí odkaz:
https://doaj.org/article/cb619365e89b48d6ba45e277a7ab513f
Autor:
Sinnberg, Heike Niessner, Markus Burkard, Christian Leischner, Olga Renner, Sarah Plöger, Francisco Meraz-Torres, Matti Böcker, Constanze Hirn, Ulrich M. Lauer, Sascha Venturelli, Christian Busch, Tobias
Publikováno v:
Cells; Volume 11; Issue 7; Pages: 1229
High-dose ascorbate paradoxically acts as a pro-oxidant causing the formation of hydrogen peroxide in an oxygen dependent manner. Tumor cells (in particular melanoma cells) show an increased vulnerability to ascorbate induced reactive oxygen species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::10bf979d7b572aadaf1c6e420e06b4c8
Publikováno v:
Cancers, Vol 12, Iss 3538, p 3538 (2020)
New therapeutic concepts such as anti-PD-1-based immunotherapy or targeted therapy with BRAF and MEK inhibitors have significantly improved the survival of melanoma patients. However, about 20% of patients with targeted therapy and up to 50% with imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::6667ea0346164f2552a3dd639b071c6b
https://www.mdpi.com/2072-6694/12/12/3538
https://www.mdpi.com/2072-6694/12/12/3538
Publikováno v:
Expert opinion on biological therapy. 17(12)
Ten to fifteen percent of melanoma patients develop distant or unresectable metastasis requiring systemic treatment. Around 45% of the patients diagnosed with metastatic cutaneous melanoma harbor a BRAFV600 mutation and derive benefit from combined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a509f2c9106992baf84ea22a51dec9
https://pubmed.ncbi.nlm.nih.gov/28891339
https://pubmed.ncbi.nlm.nih.gov/28891339