Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Autor: Francisco Javier Rodriguez-Jimenez, Juan Ureña-Peralta, Pavla Jendelova, Slaven Erceg

Publikováno v: Journal of Advanced Research, Vol 54, Iss , Pp 105-118 (2023)

Background: Synaptic dysfunction is a major contributor to Alzheimeŕs disease (AD) pathogenesis in addition to the formation of neuritic β-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features

Externí odkaz: https://doaj.org/article/c8db61961ddf4949b9acbca33d3b4387

Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells

Autor: Eleonora Clemente, Antonio Vidal-Puig, Andrew R. Bassett, Francisco Javier Rodriguez-Jimenez, Ana Artero-Castro, Marta Corton, Almudena Avila-Fernandez, Pavla Jendelova, Carmen Ayuso, Erceg Slaven, Kathleen Long

Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 2092, p 2092 (2021)
Volume 22
Issue 4

Hereditary retinal dystrophies (HRD) represent a significant cause of blindness, affecting mostly retinal pigment epithelium (RPE) and photoreceptors (PRs), and currently suffer from a lack of effective treatments. Highly specialized RPE and PR cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb7ad7e92e6e3064a155fa374f07aee
https://www.repository.cam.ac.uk/handle/1810/317957

Activation of Neurogenesis in Multipotent Stem Cells Cultured In Vitro and in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3

Autor: Juliette Leal, Victoria Moreno-Manzano, Miodrag Stojkovic, Santos Fustero, Slaven Erceg, Raquel Román, Pavla Jendelova, Angel Vilches, Eleonora Clemente, Ana Artero Castro, Maria Amparo Perez-Arago, Francisco Javier Rodriguez-Jimenez

Publikováno v: Francisco Javier Rodriguez-Jimenez Vilches, Angel Perez-Arago, Maria Amparo Clemente, Eleonora Roman, Raquel Leal, Juliette Artero Castro, Ana Fustero Lardiés, Santos Moreno-Manzano, Victoria Jendelova, Pavla Stojkovic, Miodrag Erceg, Slaven 2020 Activation of Neurogenesis in Multipotent Stem Cells Cultured In Vitro and in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3 Neurotherapeutics 18 515 533
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname

The inhibition of glycogen synthase kinase-3 (GSK-3) can induce neurogenesis, and the associated activation of Wnt/β-catenin signaling via GSK-3 inhibition may represent a means to promote motor function recovery following spinal cord injury (SCI) v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89485cac4725a33502e998ac55ee4ee6
https://hdl.handle.net/10550/82709

Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors

Autor: Ana Artero-Castro, Francisco Javier Rodriguez-Jimenez, Pavla Jendelova, Kirstin B. VanderWall, Jason S. Meyer, Slaven Erceg

Publikováno v: Progress in neurobiology. 193

Glaucoma, one of the most common causes of blindness in developing countries today, involves a progressive loss of neural cells in the optic nerve that leads to progressive, irreversible vision loss. Increased intraocular pressure (IOP) presents as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264ae49e4894408ca00ecd0cba4b257c
https://pubmed.ncbi.nlm.nih.gov/32360241

Deciphering retinal diseases through the generation of three dimensional stem cell-derived organoids: Concise Review

Autor: Ana Artero Castro, Francisco Javier Rodriguez Jimenez, Pavla Jendelova, Slaven Erceg

Publikováno v: Stem Cells (Dayton, Ohio)

Three-dimensional (3D) retinal organoids, in vitro tissue structures derived from self-organizing cultures of differentiating human embryonic stem cells or induced pluripotent stem cells, could recapitulate some aspects of the cytoarchitectural struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8ca7a1914c5590b3ee36c4fcd25c89
https://pubmed.ncbi.nlm.nih.gov/31617949