Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Francisco Javier Ortiz-López"'
Autor:
Laura Prado-Alonso, Suhui Ye, Ignacio Pérez-Victoria, Ignacio Montero, Pedro Riesco, Francisco Javier Ortiz-López, Jesús Martín, Carlos Olano, Fernando Reyes, Carmen Méndez
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1084 (2024)
Natural products play a crucial role in drug development, addressing the escalating microbial resistance to antibiotics and the treatment of emerging diseases. Progress in genome sequencing techniques, coupled with the development of bioinformatics t
Externí odkaz:
https://doaj.org/article/3c82615f29c144ff9504fdf961a4057f
Autor:
Daniel Oves-Costales, Tetiana Gren, Eva Baggesgaard Sterndorff, Jesús Martín, Francisco Javier Ortiz-López, Tue S. Jørgensen, Xinglin Jiang, Fernando Román-Hurtado, Fernando Reyes, Olga Genilloud, Tilmann Weber
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 2, Pp 206-212 (2023)
Globomycin is a cyclic lipodepsipeptide originally isolated from several Streptomyces species which displays strong and selective antibacterial activity against Gram-negative pathogens. Its mode of action is based on the competitive inhibition of the
Externí odkaz:
https://doaj.org/article/e800521b7d924a0689d8306ad9d65e4a
Autor:
Julia P. Deisinger, Melina Arts, Ioli Kotsogianni, Jan-Samuel Puls, Fabian Grein, Francisco Javier Ortiz-López, Nathaniel I. Martin, Anna Müller, Olga Genilloud, Tanja Schneider
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106394- (2023)
Summary: Antibiotic resistance is reaching alarming levels, demanding for the discovery and development of antibiotics with novel chemistry and mechanisms of action. The recently discovered antibiotic cacaoidin combines the characteristic lanthionine
Externí odkaz:
https://doaj.org/article/82a0b81353d2487f907b093a53470d73
Autor:
Aida Sarmiento-Vizcaíno, Jesús Martín, Francisco Javier Ortiz-López, Fernando Reyes, Luis A. García, Gloria Blanco
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited
Externí odkaz:
https://doaj.org/article/a55eb7e2759c44ec8e206f80f1ced647
Autor:
Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber
Publikováno v:
Molecules, Vol 26, Iss 21, p 6580 (2021)
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by heter
Externí odkaz:
https://doaj.org/article/86badcd3f9eb4ba6bb5883784ca814da
Autor:
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortiz-López, Olga Genilloud
Publikováno v:
Antibiotics, Vol 10, Iss 4, p 403 (2021)
Cacaoidin is produced by the strain Streptomyces cacaoi CA-170360 and represents the first member of the new lanthidin (class V lanthipeptides) RiPP family. In this work, we describe the complete identification, cloning and heterologous expression of
Externí odkaz:
https://doaj.org/article/4a24d362449e41aa963cb9f28add696b
Autor:
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortiz-López, Daniel Carretero-Molina, Fernando Reyes, Olga Genilloud
Publikováno v:
Microorganisms, Vol 9, Iss 1, p 135 (2021)
The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two non-ribosomal peptide synthetases encoded in tandem within the same biosynthetic gen
Externí odkaz:
https://doaj.org/article/a0c1332f71f641eeb62929fc32a21554
Autor:
Gloria Crespo, Ignacio Pérez-Victoria, Francisco Javier Ortiz-López, Víctor González-Menéndez, Mercedes de la Cruz, Bastien Cautain, Pilar Sánchez, Francisca Vicente, Olga Genilloud, Fernando Reyes
Publikováno v:
Antibiotics, Vol 9, Iss 6, p 278 (2020)
An antifungal lipodepsipeptide was obtained from cultures of the fungus Foliophoma fallens CF-236885. Its structure, elucidated by HRMS and NMR spectroscopy, contained Gly, Thr, Asn, β-Ala, Orn, Ala, two Ser residues, and 3-hydroxy-4-methylhexadecan
Externí odkaz:
https://doaj.org/article/e08d3aec24ec42afb23378e9b6005d4e
Autor:
Daniel Carretero-Molina, Francisco Javier Ortiz-López, Jesús Martín, Daniel Oves-Costales, Caridad Díaz, Mercedes de la Cruz, Bastien Cautain, Francisca Vicente, Olga Genilloud, Fernando Reyes
Publikováno v:
Marine Drugs, Vol 18, Iss 1, p 22 (2019)
As part of our continuing efforts to discover new bioactive compounds from microbial sources, a reinvestigation of extracts of scaled-up cultures of the marine-derived Streptomyces sp. strain CA-271078 resulted in the isolation and structural elucida
Externí odkaz:
https://doaj.org/article/aabed86dd04e4745abb4d917123f8973
Autor:
Francisco Javier Ortiz-López, Elsa Alcalde, Aida Sarmiento-Vizcaíno, Caridad Díaz, Bastien Cautain, Luis A. García, Gloria Blanco, Fernando Reyes
Publikováno v:
Marine Drugs, Vol 16, Iss 10, p 371 (2018)
Fractionation of the bioactive extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-157 led to the isolation of the known 3-hydroxyquinaldic acid (4), its amide (5) and three new derivatives (1–3) containing differe
Externí odkaz:
https://doaj.org/article/75ac035dbc8c4977ac64a3dfb1b4d5c2