Defects of Nutrient Signaling and Autophagy in Neurodegeneration

Autor: Jon Ondaro, Haizea Hernandez-Eguiazu, Maddi Garciandia-Arcelus, Raúl Loera-Valencia, Laura Rodriguez-Gómez, Andrés Jiménez-Zúñiga, Julen Goikolea, Patricia Rodriguez-Rodriguez, Javier Ruiz-Martinez, Fermín Moreno, Adolfo Lopez de Munain, Ian James Holt, Francisco Javier Gil-Bea, Gorka Gereñu

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Neurons are post-mitotic cells that allocate huge amounts of energy to the synthesis of new organelles and molecules, neurotransmission and to the maintenance of redox homeostasis. In neurons, autophagy is not only crucial to ensure organelle renewal

Externí odkaz: https://doaj.org/article/d5a931fe69ce457aa2252150533d313b

ALS-derived fibroblasts exhibit reduced proliferation rate, cytoplasmic TDP-43 aggregation and a higher susceptibility to DNA damage

Autor: Javier Riancho, Miguel Lafarga, Carlos Durán-Vían, Olga Tapia, Francisco Javier Gil-Bea, Jana Arozamena, David Castanedo-Vazquez, Adolfo López de Munain, María José Sedano, Maria T. Berciano

Publikováno v: Journal of Neurology. 267:1291-1299

Dermic fibroblasts have been proposed as a potential genetic-ALS cellular model. This study aimed to explore whether dermic fibroblasts from patients with sporadic-ALS (sALS) recapitulate alterations typical of ALS motor neurons and exhibit abnormal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11c1c56c7d94fb68afc4b0085fcba138
https://doi.org/10.1007/s00415-020-09704-8

A multicentre validation study of the diagnostic value of plasma neurofilament light

Autor: A. Lleo, Oskar Hansson, Gorka Fernández-Eulate, Bruce L. Miller, Pedro Rosa-Neto, Nicholas J. Ashton, Ahmad Al Khleifat, Susan M. Resnick, Erik Stomrud, Lucilla Parnetti, Latha Velayudhan, Sebastian Palmqvist, Thomas K. Karikari, Kaj Blennow, Gil D. Rabinovici, Andrea Lessa Benedet, Francisco Javier Gil-Bea, Adolfo López de Munain, Lenka Novakova, Alessandro Padovani, Laura Bonanni, Carmine M. Pariante, Markus Axelsson, Naghmeh Nikkheslat, Alexander Santillo, Ammar Al-Chalabi, Abdul Hye, Henrik Zetterberg, Emma L. van der Ende, Andrea Pilotto, John C. van Swieten, Madhav Thambisetty, Dag Aarsland, Jan Lycke, Daniela Galimberti, Per Svenningsson, Michael Schöll, Shorena Janelidze, Tharick A. Pascoal, Andre Strydom, Antoine Leuzy

Publikováno v: Nature Communications
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Nature communications, vol 12, iss 1
Nature Communications, 12(1):3400. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321e1a9b9168bdbede33e42548b26c89
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7766

Clinical evidences supporting the Src/c-Abl pathway as potential therapeutic target in amyotrophic lateral sclerosis

Autor: Gorka Fernández Garcia de Eulate, Mónica Zufiría, Francisco Javier Gil-Bea, María José Sedano, Juan José Poza, Javier Riancho, David Castanedo-Vazquez, Adolfo López de Munain

Publikováno v: Journal of the Neurological Sciences. 393:80-82

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::326ddc42de7b3b178bfb812a904cca44
https://doi.org/10.1016/j.jns.2018.08.013

Resistance Training Does not have an Effect on Cognition or Related Serum Biomarkers in Nonagenarians: A Randomized Controlled Trial

Autor: Gabriel Rodríguez-Romo, Jonatan R. Ruiz, Francisco-Javier Gil-Bea, Natalia Bustamante-Ara, José Antonio Serra-Rexach, Alejandro Lucia, Angel Cedazo-Minguez, Carmen Fiuza-Luces

Publikováno v: International Journal of Sports Medicine. 36:54-60

The aim of this randomized controlled trial was to determine the effects of 8-week exercise-intervention on cognition and related serum biochemical markers in nonagenarians. We also studied the effects of a 4-week training cessation (‘detraining’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73968df75050314615a21703ee8432d4
https://doi.org/10.1055/s-0034-1375693