Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Autor: Rubén Daniel Arellano Pérez Vertti, Alejandra Méndez Hernández, Perla Karina Espino Silva, Francisco Javier Blanco García, Rafael Arguello Astorga, Lizette Sarai Aguilar Muñiz, Faviel Francisco González Galarza, Fernando Hernández Terán, Adria Imelda Prieto Hinojosa

Publikováno v: Genetic Testing and Molecular Biomarkers. 24:375-380

Aims: To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c61c62b1fb0879570a4f19497c3b4732
https://doi.org/10.1089/gtmb.2019.0266

Recommendations by the Spanish Rheumatology Society for the Management of Patients Diagnosed With Rheumatoid Arthritis who Cannot Be Treated With Methotrexate

Autor: Sara Marsal-Barril, Ricardo Blanco-Alonso, Jesús Tornero-Molina, Antonio Fernández-Nebro, María Rosa Gonzalez-Crespo, Rosario García-Vicuña, María A. Martín-Martínez, Francisco Javier Blanco-García

Publikováno v: Reumatología Clínica (English Edition). 13:127-138

To establish a set of recommendations for the management of patients diagnosed with rheumatoid arthritis (RA) who cannot be treated with methotrexate (MTX) due to contraindications, drug toxicity or lack of adherence, and to establish therapeutic str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2f9253f8d57cf1e7cbb3463defc1304
https://doi.org/10.1016/j.reumae.2016.10.002

Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week randomised, double-blind, placebo-controlled period of the SPIRIT-P2 phase 3 trial

Autor: Peter Nash, Bruce Kirkham, Masato Okada, Proton Rahman, Benard Combe, Gerd-Ruediger Burmester, David H Adams, Lisa Kerr, Chin Lee, Catherine L Shuler, Mark Genovese, Khalid Ahmed, Jeffrey Alper, Nichol Barkham, Ralph E. Bennett, Francisco Javier Blanco García, Ricardo Blanco Alonso, Howard B. Blumstein, Michael S. Brooks, Gerd-Rüdiger Burmester, Patricia Cagnoli, Paul H. Caldron, Alain Cantagrel, Der-Yuan Chen, Melvin A. Churchill, Christine E. Codding, Peter M.G. Deane, Jose Del Giudice, Atul A. Deodhar, Rajat K. Dhar, Eva Dokoupilova, Rita M. Egan, Andrea Everding, Eva Galíndez, David H. Goddard, Alice Gottlieb, Philippe Goupille, Robert M. Griffin, Ramesh C. Gupta, Stephen Hall, Kalpita Hatti, Mary P. Howell, Yu-Huei Huang, Ramina Jajoo, Namieta M. Janssen, Uta Kiltz, Alan J. Kivitz, Steven J. Klein, Mariusz P. Korkosz, Roshan Kotha, Joel M. Kremer, Cummins Lue, José Luis Marenco de la Fuente, Helena Marzo-Ortega, Jordi Gratacós Masmitja, Philip J. Mease, Pier Luigi Meroni, Eric C. Mueller, Anupama C. Nandagudi, Antonio Fernández-Nebro, Clark M. Neuwelt, Ana Maria Orbai, Meera R. Oza, Deborah L. Parks, Debendra Pattanaik, Maria E. Rell-Bakalarska, David Rosmarin, Euthalia Roussou, Anna I. Rychlewska-Hanczewksa, David H. Sikes, Michael T. Stack, Prashanth Sunkureddi, Hasan Tahir, Diamant Thaçi, Tsen-Fang Tsai, Anthony M. Turkiewicz, Leonore Unger, Raúl Veiga Cabello, Ulf Wagner, Cheng-Chung Wei, Alvin F. Wells, Peter Youssef, Agnieszka Zielinska

Publikováno v: Lancet (London, England). 389(10086)

Patients who have had inadequate response to tumour necrosis factor inhibitors have fewer treatment options and are generally more treatment refractory to subsequent therapeutic interventions than previously untreated patients. We report the efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e86bed9c822e2b158c34f88e2aa99b8
https://pubmed.ncbi.nlm.nih.gov/28592895

[Treatment of joint cartilage lesions with cell therapy]

Autor: Isaac Manuel, Fuentes-Boquete, María, Del Carmen Arufe Gonda, Silvia María, Díaz Prado, Tamara, Hermida Gómez, Francisco Javier, de Toro Santos, Francisco Javier, Blanco García

Publikováno v: Reumatologia clinica. 3

Articular cartilage lesions which do not affect the integrity of subchondral bone, they are not able to repair it expontaneously. The asymptomatic nature of these lesions induces articular cartilage degeneration and development of an arthrosic proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::17930aa849fed0da671bbccc54c8690f
https://pubmed.ncbi.nlm.nih.gov/21794485