Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation

Autor: Emilio Llanos-González, Francisco J. Sancho-Bielsa, Javier Frontiñán-Rubio, Yoana Rabanal-Ruíz, Sonia García-Carpintero, Eduardo Chicano, Isabel Úbeda-Banon, Alicia Flores-Cuadrado, Lydia Giménez-Llort, Francisco Javier Alcaín, Juan Ramón Peinado, Mario Durán-Prado

Publikováno v: Antioxidants, Vol 12, Iss 3, p 747 (2023)

Despite its robust proteopathic nature, the spatiotemporal signature of disrupted protein modules in sporadic Alzheimer’s disease (AD) brains remains poorly understood. This considered oxidative stress contributes to AD progression and early interv

Externí odkaz: https://doaj.org/article/5e9afe27b74e480e8c3e4841c1e0ff83

Neutrophilic dermatoses in a patient with collagenous colitis

Autor: Didac Barco, Maria A. Barnadas, Esther Roé, Francisco J. Sancho, Elena Ricart, Agustín Alomar

Publikováno v: Dermatology Reports, Vol 2, Iss 1, Pp e5-e5 (2010)

We report the case of a 75-year old woman with collagenous colitis who presented with erythematous and edematous plaques on the periorbital and eyelid regions, accompanied by oral ulcers. Histopathology showed a dermal neutrophilic infiltrate plus mi

Externí odkaz: https://doaj.org/article/f8698a5915254f9c90ce3c644683fdac

Modelos experimentales murinos en la esclerosis lateral amiotrófica. Puesta al día

Autor: Alejandro A. Canales-Aguirre, J.C. Mateos-Díaz, Francisco J. Sancho-Bielsa, Jorge Matías-Guiu, María Soledad Benito-Martín, Lidia Moreno-Jiménez, Inmaculada Sanclemente-Alaman, Jordi A. Matías-Guiu, Ulises Gómez-Pinedo, J. Aguilar

Publikováno v: Neurología.

Resumen Introduccion La esclerosis lateral amiotrofica (ELA) es una enfermedad neurodegenerativa, progresiva y de etiologia desconocida caracterizada por la degeneracion de motoneuronas superiores e inferiores. Aproximadamente el 90% de los casos de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cebbae489b3c4a64df3b71e6111ca10f
https://doi.org/10.1016/j.nrl.2021.07.007

Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

Autor: Vanesa Pytel, Yolanda García-Ávila, Lucía Gallego-Villarejo, Lidia Moreno-Jiménez, Ulises Gómez-Pinedo, Paloma Montero-Escribano, Noelia Esteban‐Garcia, Jorge Matías-Guiu, María Soledad Benito-Martín, Inmaculada Sanclemente-Alaman, Lucía Vidorreta-Ballesteros, Jordi A. Matías-Guiu, Francisco J. Sancho-Bielsa

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
Universidad Europea (UEM)
International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5192, p 5192 (2021)

Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve
remy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0d21b5e4d93f786bad39d50c5dc638
https://eprints.ucm.es/id/eprint/71667/

Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease

Autor: Juan R. Peinado, Francisco J. Alcaín, Francisco J. Sancho-Bielsa, Lydia Giménez-Llort, Mario Durán-Prado, Frank M. LaFerla, Javier Frontiñán-Rubio

Publikováno v: Molecular and Cellular Neuroscience. 92:67-81

Structural and functional abnormalities in the cerebral microvasculature have been observed in Alzheimer's disease (AD) patients and animal models. One cause of hypoperfusion is the thickening of the cerebrovascular basement membrane (CVBM) due to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a6716a26df8cbd0a6d14f435feb38c
https://doi.org/10.1016/j.mcn.2018.06.005