Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Francisco J. Monje"'
Autor:
Claudia Sagheddu, Tamara Stojanovic, Shima Kouhnavardi, Artem Savchenko, Ahmed M. Hussein, Marco Pistis, Francisco J. Monje, Roberto Plasenzotti, Mohammed Aufy, Christian R. Studenik, Jana Lubec, Gert Lubec
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionDeterioration of cognitive functions is commonly associated with aging, although there is wide variation in the onset and manifestation. Albeit heterogeneity in age-related cognitive decline has been studied at the cellular and molecular
Externí odkaz:
https://doaj.org/article/71955093d7d1495cbc30f67de0923ba9
Autor:
Serena Vaglietti, Veronica Villeri, Marco Dell’Oca, Chiara Marchetti, Federico Cesano, Francesca Rizzo, Dave Miller, Louis LaPierre, Ilaria Pelassa, Francisco J. Monje, Luca Colnaghi, Mirella Ghirardi, Ferdinando Fiumara
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108036- (2023)
Summary: The transcription factor FOXP2, a regulator of vocalization- and speech/language-related phenotypes, contains two long polyQ repeats (Q1 and Q2) displaying marked, still enigmatic length variation across mammals. We found that the Q1/Q2 leng
Externí odkaz:
https://doaj.org/article/304951f226884f87b54600094b5b4f0c
Autor:
Shima Kouhnavardi, Maureen Cabatic, M. Carmen Mañas-Padilla, Marife-Astrid Malabanan, Tarik Smani, Ana Cicvaric, Edison Alejandro Muñoz Aranzalez, Xaver Koenig, Ernst Urban, Gert Lubec, Estela Castilla-Ortega, Francisco J. Monje
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9565 (2023)
Cortisol is a potent human steroid hormone that plays key roles in the central nervous system, influencing processes such as brain neuronal synaptic plasticity and regulating the expression of emotional and behavioral responses. The relevance of cort
Externí odkaz:
https://doaj.org/article/4af953bb27324ed4be67bf3616bd73b2
Autor:
Stefanie Berger, Miranda Stattmann, Ana Cicvaric, Francisco J. Monje, Pierluca Coiro, Matej Hotka, Gerda Ricken, Johannes Hainfellner, Susanne Greber-Platzer, Makiko Yasuda, Robert J. Desnick, Daniela D. Pollak
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract Acute intermittent porphyria (AIP) is an autosomal dominant inborn error of heme biosynthesis due to a pathogenic mutation in the Hmbs gene, resulting in half-normal activity of hydroxymethylbilane synthase. Factors that induce hepatic heme
Externí odkaz:
https://doaj.org/article/b77fe68a1af2443eaa85c7d997dd706f
Autor:
Shima Kouhnavardi, Alev Ecevitoglu, Vladimir Dragačević, Fabrizio Sanna, Edgar Arias-Sandoval, Predrag Kalaba, Michael Kirchhofer, Jana Lubec, Marco Niello, Marion Holy, Martin Zehl, Matthias Pillwein, Judith Wackerlig, Rita Murau, Andrea Mohrmann, Kathryn R. Beard, Harald H. Sitte, Ernst Urban, Claudia Sagheddu, Marco Pistis, Roberto Plasenzotti, John D. Salamone, Thierry Langer, Gert Lubec, Francisco J. Monje
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 881 (2022)
Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning and memory, and social and re
Externí odkaz:
https://doaj.org/article/ea4993ee98834d4a80993681061f26a1
Autor:
Tamara Stojanovic, David Velarde Gamez, Gabor Jorrid Schuld, Daniel Bormann, Maureen Cabatic, Pavel Uhrin, Gert Lubec, Francisco J. Monje
Publikováno v:
Cells, Vol 11, Iss 2, p 261 (2022)
Nicotine addiction develops predominantly during human adolescence through smoking. Self-administration experiments in rodents verify this biological preponderance to adolescence, suggesting evolutionary-conserved and age-defined mechanisms which inf
Externí odkaz:
https://doaj.org/article/d30a70908ce44280bd22b07ce2e7fd23
Autor:
Ana Cicvaric, Hannah M. Sachernegg, Tamara Stojanovic, Dörte Symmank, Tarik Smani, Thomas Moeslinger, Pavel Uhrin, Francisco J. Monje
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has been identified in proliferati
Externí odkaz:
https://doaj.org/article/125b502dc0e24e03b1d044c1ecd321a8
Autor:
Daniel Bormann, Tamara Stojanovic, Ana Cicvaric, Gabor J. Schuld, Maureen Cabatic, Hendrik Jan Ankersmit, Francisco J. Monje
Publikováno v:
Cells, Vol 10, Iss 7, p 1709 (2021)
Cerebral ischemia and its sequelae, which include memory impairment, constitute a leading cause of disability worldwide. Micro-RNAs (miRNA) are evolutionarily conserved short-length/noncoding RNA molecules recently implicated in adaptive/maladaptive
Externí odkaz:
https://doaj.org/article/503a5d8c8d7c459bb0474eb03cae4515
Autor:
Christopher W Fell, Astrid Hagelkruys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Venkat Swaroop Achuta, Angelica Scaramuzza, Kimberly A Twyman, Michelle M Morrow, Jane Juusola, Huifang Yan, Jingmin Wang, Margit Burmeister, Biswa Choudhury, Thomas Levin Andersen, Gerald Wirnsberger, Uffe Holmskov, Norbert Perrimon, Bojan Žagrović, Francisco J Monje, Jesper Bonnet Moeller, Josef M Penninger, Vanja Nagy
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp n/a-n/a (2022)
Abstract Whole‐exome sequencing of two patients with idiopathic complex neurodevelopmental disorder (NDD) identified biallelic variants of unknown significance within FIBCD1, encoding an endocytic acetyl group‐binding transmembrane receptor with
Externí odkaz:
https://doaj.org/article/97ff532b47a541dcbc19af3c49df7a36
Autor:
Marija Ilic, Jana Lubec, Alexander Roller, Vladimir Dragačević, Jovana Malikovic, Shima Kouhnavardi, Johann Leban, Roberto Plasenzotti, Simone B. Sartori, Thierry Langer, Predrag Kalaba, Marco Pistis, Judith Wackerlig, Christian Pifl, Daniel Daba Feyissa, Martin Zehl, Karl Ebner, Nicolas Singewald, Ernst Urban, Claudia Sagheddu, Arthur Garon, Mohamed H. Kotob, Ahmed M. Hussein, Rasha Refaat Mahmmoud, Francisco J. Monje, Natalie Gajic, Anita Cybulska-Klosowicz, Oliver Wieder, Gert Lubec, Harald H. Sitte, Volker Korz
Publikováno v:
Molecular Psychiatry. 26:7076-7090
Aging-related neurological deficits negatively impact mental health, productivity, and social interactions leading to a pronounced socioeconomic burden. Since declining brain dopamine signaling during aging is associated with the onset of neurologica