Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Francisco J. Martinez-Wittinghan"'
Autor:
Caterina Sellitto, Thomas W. White, Miduturu Srinivas, Francisco J. Martinez-Wittinghan, Richard T. Mathias
Publikováno v:
Journal of Membrane Biology. 211:163-171
Mefloquine (MFQ) selectively blocks exogenously expressed gap junction channels composed of Cx50 but not Cx46. The purpose of the current study was to evaluate MFQ effects on wild-type (WT) mouse lenses that express both Cx50 and Cx46 in their outer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a540a2f89529b4ac364f1fe83160440
https://doi.org/10.1007/s00232-006-0021-6
https://doi.org/10.1007/s00232-006-0021-6
Autor:
Thomas W. White, Junyuan Gao, Xiaohua Gong, Richard T. Mathias, Francisco J. Martinez-Wittinghan, Xiurong Sun
Publikováno v:
The Journal of General Physiology
There is a good deal of evidence that the lens generates an internal micro circulatory system, which brings metabolites, like glucose, and antioxidants, like ascorbate, into the lens along the extracellular spaces between cells. Calcium also ought to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87af3ef9d56e2272fa830ed5966d6613
https://doi.org/10.1085/jgp.200409121
https://doi.org/10.1085/jgp.200409121
Autor:
Richard T. Mathias, Nalin M. Kumar, Norton B. Gilula, Xiaohua Gong, Francisco J. Martinez-Wittinghan, George J. Baldo
Publikováno v:
The Journal of General Physiology
Lens fiber cell gap junctions contain alpha(3) (Cx46) and alpha(8) (Cx50) connexins. To examine the roles of the two different connexins in lens physiology, we have genetically engineered mice lacking either alpha(3) or alpha(8) connexin. Intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e5d9f7e12136ca80ad3528a33f89e0
http://europepmc.org/articles/PMC2233836
http://europepmc.org/articles/PMC2233836
Autor:
Francisco J. Martinez-Wittinghan, Kendra A. Miller, Satyabrata Das, Snehalata Jena, Dolores J. Takemoto, Samuel A. Molina, Richard T. Mathias, Huan Wang, Leonie K. Bossmann
Publikováno v:
Current eye research. 36(7)
To determine the role of PKCγ in the regulation of gap junction coupling in the normal lens, we have compared the properties of coupling in lenses from wild type (WT) and PKC-γ knockout (KO) mice.Western blotting, confocal immunofluorescence micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0097473af1e97be518609cd4af5d4854
https://pubmed.ncbi.nlm.nih.gov/21599470
https://pubmed.ncbi.nlm.nih.gov/21599470
Autor:
Thomas W. White, Huan Wang, Kulandaiappan Varadaraj, Leping Li, Venkat N. Reddy, Melissa Farrell, Junyuan Gao, Richard T. Mathias, Xiurong Sun, Francisco J. Martinez-Wittinghan
Publikováno v:
The Journal of membrane biology. 227(1)
Glutathione peroxidase-1 (GPX-1) is an enzyme that protects the lens against H2O2-mediated oxidative damage. The purpose of the present study was to determine the effects of GPX-1 knockout (KO) on lens transport and intracellular homeostasis. To inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87be440f3a6d0035ab87d39dcdeab9a3
https://pubmed.ncbi.nlm.nih.gov/19067024
https://pubmed.ncbi.nlm.nih.gov/19067024
Publikováno v:
Gap Junctions in Development and Disease ISBN: 3540261567
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58d83befc1a9dcc1cfd0fc4e12cdc1e1
https://doi.org/10.1007/3-540-28621-7_8
https://doi.org/10.1007/3-540-28621-7_8
Autor:
David L. Paul, Richard T. Mathias, Daniel A. Goodenough, Thomas W. White, Caterina Sellitto, Francisco J. Martinez-Wittinghan
Publikováno v:
Investigative ophthalmologyvisual science. 45(10)
PURPOSE. To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS. Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2076503d9e12f8559903ce7dc9fc2b1
https://pubmed.ncbi.nlm.nih.gov/15452070
https://pubmed.ncbi.nlm.nih.gov/15452070
Autor:
Leping Li, Xiaohua Gong, Caterina Sellitto, Francisco J. Martinez-Wittinghan, Richard T. Mathias, Thomas W. White, Peter R. Brink
Publikováno v:
The Journal of Cell Biology
Gap junctions are composed of proteins called connexins (Cx) and facilitate both ionic and biochemical modes of intercellular communication. In the lens, Cx46 and Cx50 provide the gap junctional coupling needed for homeostasis and growth. In mice, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d284e07bc17ae8ba2a341a9c5d7285c9
https://pubmed.ncbi.nlm.nih.gov/12782682
https://pubmed.ncbi.nlm.nih.gov/12782682