Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Francisco J. Gil-Bea"'
Autor:
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L. van der Ende, Thomas K. Karikari, Andrea L. Benedet, Tharick A. Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D. Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M. Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J. Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C. van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/5a53b0a732414b4ca05246e46c25baa3
Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice
Autor:
Francisco J. Gil-Bea, Gorka Gerenu, Barbara Aisa, Ludmil P. Kirazov, Reinhard Schliebs, Maria J. Ramírez
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 439-446 (2012)
The main pathological hallmarks of Alzheimer's disease (AD) consist of amyloid plaques and neurofibrillary tangles. Hippocampal cell loss, atrophy and cholinergic dysfunction are also features of AD. The present work is aimed at studying the interact
Externí odkaz:
https://doaj.org/article/80ada149b6db43b5a4d11ba67bba312f
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 2, Pp 193-196 (2019)
Amyotrophic lateral sclerosis, the most common neurodegenerative disease affecting motor neurons, lacks an effective treatment. A small fraction of amyotrophic lateral sclerosis cases have a familial origin, related to mutations in causative genes, w
Externí odkaz:
https://doaj.org/article/5e7b65a24df54edeb05e6cbd74dbd1a2
Autor:
Ismael Izquierdo-Villalba, Serena Mirra, Yasmina Manso, Antoni Parcerisas, Javier Rubio, Jaume Del Valle, Francisco J. Gil-Bea, Fausto Ulloa, Marina Herrero-Lorenzo, Ester Verdaguer, Cristiane Benincá, Rubén D. Castro-Torres, Elena Rebollo, Gemma Marfany, Carme Auladell, Xavier Navarro, José A. Enríquez, Adolfo López de Munain, Anna M. Aragay, Eduardo Soriano
In neurons, mitochondrial dynamics and trafficking are essential to provide the energy required for neurotransmission and neuronal activity. Recent studies point to GPCR and G proteins as important regulators of mitochondrial dynamics and energy meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625cdf89e575a19f4b2cdff578f81e07
https://doi.org/10.1101/2021.12.09.471902
https://doi.org/10.1101/2021.12.09.471902
Autor:
Marta Zamarbide, Eva Martinez-Pinilla, Francisco J Gil-Bea, Masashi Yanagisawa, Rafael Franco, Alberto Pérez-Mediavilla
The free fatty acid FFA3 receptor (FFA3R) belongs to the superfamily of G-protein-coupled receptors (GPCRs). In the intestine and adipose tissue, it is involved in the regulation of energy metabolism but its function in the brain is unknown. We aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9480d3633e56ce201bb202c001af2b99
https://doi.org/10.21203/rs.3.rs-1124827/v1
https://doi.org/10.21203/rs.3.rs-1124827/v1
Autor:
Montserrat Esteve, Joana Pérez de San Román, Felix Junyent, María J. Ramírez, Grasa Mm, Angelo Ledda, Francisco J. Gil-Bea, José Gulfo
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246930 (2021)
Universidad de Barcelona
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246930 (2021)
Corticosteroid-binding globulin (CBG) is the specific carrier of circulating glucocorticoids, but evidence suggests that it also plays an active role in modulating tissue glucocorticoid activity. CBG polymorphisms affecting its expression or affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa6b1310837c928c1c27d4dc46919cf
http://hdl.handle.net/2445/175036
http://hdl.handle.net/2445/175036
Autor:
Alessandro Padovani, Susan M. Resnick, Pedro Rosa-Neto, Laura Bonanni, Naghmeh Nikkheslat, Adolfo López de Munain, Dag Aarsland, Ammar Al-Chalabi, Carmine M. Pariante, Emma L. van der Ende, Andrea Pilotto, Francisco J. Gil-Bea, John C. van Swieten, Antoine Leuzy, Ahmad Al Khleifat, Thomas K. Karikari, Lenka Novakova, Lucilla Parnetti, Per Svenningsson, Oskar Hansson, Madhav Thambisetty, Jan Lycke, Henrik Zetterberg, Gil D. Rabinovici, Nicholas J. Ashton, Bruce L. Miller, Sebastian Palmqvist, Alberto Lleó, Gorka Fernández-Eulate, Daniela Galimberti, Alexander Santillo, Latha Velayudhan, Erik Stomrud, Abdul Hye, Kaj Blennow, Shorena Janelidze, Tharick A. Pascoal, Michael Schöll, Andrea Lessa Benedet, Andre Strydom, Markus Axelsson
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in fifteen neurodegenerative diseases from tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fceda89f4c1270662cd4a42091eda01
https://doi.org/10.21203/rs.3.rs-63386/v1
https://doi.org/10.21203/rs.3.rs-63386/v1
Autor:
Hilda Ferrero, Francisco J. Gil-Bea, María J. Ramírez, Eva Martisova, Tomi Rantamäki, Miguel Carracedo, Gorka Gerenu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:991-1001
Brain-derived neurotrophic factor (BDNF) plays pivotal roles in neuronal function. The cleaved - mature - form of BDNF (mBDNF), predominantly expressed in adult brains, critically determines its effects. However, insufficient proteolytic processing u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a66f7772e98cd16e515c34f5de7885
https://doi.org/10.1016/j.bbadis.2017.01.023
https://doi.org/10.1016/j.bbadis.2017.01.023
Autor:
Olatz Arrizabalaga, Miren Revuelta, Angel R. Nebreda, Leire Moreno-Cugnon, Daniel Jimenez-Blasco, Juan P. Bolaños, Ander Matheu, Irantzu Llarena, Francisco J. Gil-Bea, Sandra Colié, Manuel Moreno-Valladares
Publikováno v:
GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
Digital.CSIC. Repositorio Institucional del CSIC
Aging Cell
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
instname
Digital.CSIC. Repositorio Institucional del CSIC
Aging Cell
GREDOS: Repositorio Institucional de la Universidad de Salamanca
Universidad de Salamanca (USAL)
Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely unknown. In this work, we show that p38MAPK activity increases in neurons with age. By using mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794ff6dd62f4230ba005cb21fb334c76
https://doi.org/10.1111/acel.13044
https://doi.org/10.1111/acel.13044
Autor:
Ricard Rojas-García, Adolfo López de Munain, José Luis Muñoz-Blanco, Juan José Poza, Francisco J. Gil-Bea, Roberto Fernández-Torrón, Mónica Zufiría, Javier Riancho
Publikováno v:
Progress in Neurobiology. 142:104-129
The scientific scenario of amyotrophic lateral sclerosis (ALS) has dramatically changed since TDP-43 aggregates were discovered in 2006 as the main component of the neuronal inclusions seen in the disease, and more recently, when the implication of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee09494e925aefcbee8f5ee28ff967d8
https://doi.org/10.1016/j.pneurobio.2016.05.004
https://doi.org/10.1016/j.pneurobio.2016.05.004