Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Francisco J. Gamo"'
Autor:
Michael J. Delves, Celia Miguel-Blanco, Holly Matthews, Irene Molina, Andrea Ruecker, Sabrina Yahiya, Ursula Straschil, Matthew Abraham, María Luisa León, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Jochen R. Brandt, Álvaro Cortés, Anna Barnard, Matthew J. Fuchter, Félix Calderón, Elizabeth A. Winzeler, Robert E. Sinden, Esperanza Herreros, Francisco J. Gamo, Jake Baum
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential ant
Externí odkaz:
https://doaj.org/article/920f37303ca446e0a2ceaa2cbd0d76bf
Autor:
Julie M. J. Verhoef, Rosemary Rochford, Philip J. Rosenthal, Graham P. Trevitt, Patrick K Tumwebaze, Barcelo C, Manuel Llinás, Jacquin C. Niles, Koen J. Dechering, Henderson R, Roger Bonnert, Dhelio Batista Pereira, Anna Caroline Campos Aguiar, Huijs T, Judith M. Bolscher, David A. Fidock, Tomas Yeo, Robert W. Sauerwein, Pasaje Cfa, Jake Baum, Patrick A. M. Jansen, Brice Campo, Roland A. Cooper, Taco W. A. Kooij, de Vries Le, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Francisco J. Gamo, Josefine Striepen, Pedro H. H. Hermkens, Sergio Wittlin, Rafael Victorio Carvalho Guido, Kelly Rubiano, Justin Munro, Fernandez Bc, Laura M. Sanz, Karin M. J. Koolen, J. Schalkwijk, Alisje Churchyard
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defffb247aaafa1d1e8ba557aa91a1d8
https://doi.org/10.1101/2021.05.12.443866
https://doi.org/10.1101/2021.05.12.443866
Autor:
Elena Sandoval, Maria Santos Martinez-Martinez, Beatriz Hernández Díaz, Esther Fernández, Maria Jose Lafuente-Monasterio, Jeremy N. Burrows, Simon J. F. Macdonald, Sara Prats, John N. Haselden, Gerard Drewes, Pablo Castañeda, Francisco J. Gamo, J. Vidal, Jose Ignacio Martin Hernando, Benigno Crespo, Margarita Puente, David Matthew Wilson, Paul Bamborough, María Luisa León, Maria Jesus Almela, Sonja Ghidelli-Disse, Rubén M. Gómez, Jaime de Mercado, Carolyn Selenski, Jose M. Coteron, Anne Rodríguez, Cristina de Cozar, Michael J Witty, Juan C. de la Rosa, Paul Willis, Iñigo Angulo-Barturen, María J. Chaparro, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Santiago Ferrer-Bazaga, Sophie Huss, María T. Fraile, María Belén Jiménez Díaz
Publikováno v:
Journal of Medicinal Chemistry. 60:6880-6896
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfce1c3bf707c62527d304e5e25cb21
https://doi.org/10.1021/acs.jmedchem.6b01441
https://doi.org/10.1021/acs.jmedchem.6b01441
Autor:
Francisco-J. Gamo, Diver Sellanes, Laura M. Sanz, Anna Caroline Campos Aguiar, Elizabeth A. Winzeler, Catherine Fagundez, Stella Peña, Vanessa Yardley, Juliana Oliveira de Souza, Rafael Victorio Carvalho Guido, Gloria Serra, Laura Scarone, Lindsay B. Stewart, Sabine Ottilie
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
[Image: see text] Malaria is a major tropical disease where important needs are to mitigate symptoms and to prevent the establishment of infection. Cyclopeptides containing N-methyl amino acids with in vitro activity against erythrocytic forms as wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d138e287cb4e19568d42017733795a
https://europepmc.org/articles/PMC6331169/
https://europepmc.org/articles/PMC6331169/
Autor:
Paul Willis, Elena Sandoval, Carolyn Selenski, Michael J Witty, Maria Jesus Almela, Jaime de Mercado, Sonja Ghidelli-Disse, Jeremy N. Burrows, Simon J. F. Macdonald, Anne Rodríguez, Santiago Ferrer-Bazaga, Cristina de Cozar, Beatriz Hernández Díaz, Paul Bamborough, Sara Prats, Rubén M. Gómez, María Belén Jiménez Díaz, Maria Jose Lafuente-Monasterio, Iñigo Angulo-Barturen, Margarita Puente, David M. Wilson, Jose M. Coteron, Juan C. de la Rosa, Pablo Castañeda, María Luisa León, Francisco J. Gamo, Jose Ignacio Martin Hernando, John N. Haselden, María J. Chaparro, Sophie Huss, María T. Fraile, Lourdes Rueda, Félix Calderón, Nicholas Cammack, Maria Santos Martinez-Martinez, Gerard Drewes, J. Vidal, Benigno Crespo, Esther Fernández
Publikováno v:
Journal of medicinal chemistry. 60(23)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0175d454f38a34fcaa02c5eae30f5
https://pubmed.ncbi.nlm.nih.gov/28806082
https://pubmed.ncbi.nlm.nih.gov/28806082
Autor:
Douglas J. Minick, Lourdes Rueda, Santiago Ferrer, Pablo Castañeda, Francisco J. Gamo, J. Vidal, María J. Chaparro, Raquel Gabarró, María Santos Martínez, Angel Santos-Villarejo, Jose M. Coteron, Mercedes García, María Belén Jiménez-Díaz, Michael J Witty, Félix Calderón, Sara Prats, Iñigo Angulo-Barturen, Maria Jose Lafuente, Margarita Puente, Jeremy N. Burrows, Gonzalo Colmenarejo, María Luisa León, Nicholas Cammack, Jose M. Bueno, Laura Fernández de las Heras, Esther Fernández, Elena Sandoval
Publikováno v:
ACS Medicinal Chemistry Letters. 5:657-661
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea14a99c5446b043ddbd69925e99aec4
https://doi.org/10.1021/ml500015r
https://doi.org/10.1021/ml500015r
Autor:
Mariola Gordo, Elena Sandoval, Jose M. Coteron, Jiri Gut, Beatriz Hernández Díaz, María J. Chaparro, Jennifer Legac, Santiago Ferrer, David Catterick, Julia Castro, Juan Miguel, Maria L. Marco, Pilar Ventosa, Philip J. Rosenthal, Vicente Muñoz, Jose M. Fiandor, José Ruiz, Juan C. de la Rosa, Francisco J. Gamo, Esther Porras, Esther Fernández, Laura Fernández de las Heras
Publikováno v:
Journal of Medicinal Chemistry. 53:6129-6152
Falcipain-2 and falcipain-3 are papain-family cysteine proteases of the malaria parasite Plasmodium falciparum that are responsible for host hemoglobin hydrolysis to provide amino acids for parasite protein synthesis. Different heteroarylnitrile deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26636cd9e1d7aaed39cee9baeb817bce
https://doi.org/10.1021/jm100556b
https://doi.org/10.1021/jm100556b
Autor:
Geo Derimanov, Iñigo Angulo-Barturen, Santiago Ferrer, Jose M. Fiandor, Jose M. Bueno, Francisco J. Gamo, Domingo Gargallo-Viola, Esperanza Herreros
Publikováno v:
Future medicinal chemistry. 4(18)
A novel family of antimalarials based on the 4(1H)-pyridone scaffold is described. The compounds display potent antimalarial activity against Plasmodium falciparum in vitro and in vivo. Like atovaquone, 4(1H)-pyridones exert their antimalarial action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9416fea9a769947485e727dbf0f0b00
https://pubmed.ncbi.nlm.nih.gov/23234553
https://pubmed.ncbi.nlm.nih.gov/23234553
Publikováno v:
Yeast. 11:1393-1398
It has been claimed that the low-affinity component of glucose transport in Saccharomyces cerevisiae is due to passive diffusion of the sugar across the plasma membrane. We have investigated this possibility. For this purpose we have measured the per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47ed41d649b20aaee300a00daece7ae
https://doi.org/10.1002/yea.320111407
https://doi.org/10.1002/yea.320111407
Autor:
Maria J. Lafuente-Monasterio, Leila S. Ross, Paul Rowland, Onkar M. P. Singh, Dyann F. Wirth, Roger C. Wiegand, Francisco J. Gamo
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 70:C1793-C1793
Malaria is a preventable and treatable disease, yet annually there are still hundreds of thousands of malaria-related deaths. The disease is caused by infection with mosquito-borne Plasmodium parasites. With hundreds of millions of cases each year th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b209886eb0ee35e1e6084acf697b508f
https://doi.org/10.1107/s2053273314082072
https://doi.org/10.1107/s2053273314082072