Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Francisco J Roca"'
Autor:
Kevin K Takaki, Francisco J Roca, Gabriele Schramm, Ruud H P Wilbers, Wannaporn Ittiprasert, Paul J Brindley, Gabriel Rinaldi, Matthew Berriman, Lalita Ramakrishnan, Antonio J Pagán
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008814 (2021)
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of active investigation. Som
Externí odkaz:
https://doaj.org/article/61da5d83500e4279a2033dc12ad60ad2
Autor:
Raquel Espín-Palazón, Alicia Martínez-López, Francisco J Roca, Azucena López-Muñoz, Sylwia D Tyrkalska, Sergio Candel, Diana García-Moreno, Alberto Falco, José Meseguer, Amparo Estepa, Victoriano Mulero
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005699 (2016)
TNFα is a pleiotropic pro-inflammatory cytokine with a key role in the activation of the immune system to fight viral infections. Despite its antiviral role, a few viruses might utilize the host produced TNFα to their benefit. Some recent reports h
Externí odkaz:
https://doaj.org/article/6293622afeda47218377e4b3c0d26e1e
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67828 (2013)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammato
Externí odkaz:
https://doaj.org/article/c52964ffc36e486081094a0890c05709
Autor:
Jingwen Fan, Victoria L. Hale, Lindsey T. Lelieveld, Laura J. Whitworth, Elisabeth M. Busch-Nentwich, Mark Troll, Paul H. Edelstein, Timothy M. Cox, Francisco J. Roca, Johannes M. F. G. Aerts, Lalita Ramakrishnan
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. This and other lysosomal diseases occur with high frequency in Ashken
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43f608a570045b3e6a030c9bcedc777
https://doi.org/10.1073/pnas.2217673120
https://doi.org/10.1073/pnas.2217673120
Publikováno v:
Science (New York, N.Y.). 376(6600)
Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to cause pathogenic necr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2cdd5d175743774b0c446333bd9927
https://pubmed.ncbi.nlm.nih.gov/35737799
https://pubmed.ncbi.nlm.nih.gov/35737799
Autor:
Mark Troll, Antonio J. Pagán, Nguyen Duc Bang, Rajan Troll, Lalita Ramakrishnan, David M. Tobin, Paul H. Edelstein, Roger Sewell, Nguyen Hoan Phu, Nguyen Thuy Thuong Thuong, Guy E. Thwaites, Laura Whitworth, Francisco J. Roca
Publikováno v:
Proc Natl Acad Sci U S A
Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37878b23fe82738b7f4ccbf45b273d7
Autor:
Antonio J. Pagán, Paul J. Brindley, Kevin K. Takaki, Gabriele Schramm, Ruud H. P. Wilbers, Francisco J. Roca, Matthew Berriman, Wannaporn Ittiprasert, Lalita Ramakrishnan, Gabriel Rinaldi
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 15(1), 1-12
PLoS Neglected Tropical Diseases 15 (2021) 1
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008814 (2021)
PLoS Neglected Tropical Diseases, 15(1), 1-12
PLoS Neglected Tropical Diseases 15 (2021) 1
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008814 (2021)
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of active investigation. Som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9eee3f29d96193eaa62ad2ac7296c0
https://www.repository.cam.ac.uk/handle/1810/317174
https://www.repository.cam.ac.uk/handle/1810/317174
Autor:
Francisco J. Roca, Lalita Ramakrishnan, Antonio J. Pagán, Roger Sewell, Paul H. Edelstein, Mark Troll, Nguyen Thuy Thuong Thuong, Laura Whitworth, David M. Tobin, Nguyen Duc Bang, Rajan Troll, Guy E. Thwaites, Nguyen Hoan Phu
Adjunctive treatment with anti-inflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant inLeukotriene A4 Hydrolase (LTA4H), which regulates expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42be47575ceb2612516bbe0a2b5d860f
https://doi.org/10.1101/2020.11.23.394437
https://doi.org/10.1101/2020.11.23.394437
Autor:
Gabriele Schramm, Paul J. Brindley, Kevin K. Takaki, Ruud H. P. Wilbers, Matthew Berriman, Wannaporn Ittiprasert, Lalita Ramakrishnan, Francisco J. Roca, Gabriel Rinaldi, Antonio J. Pagán
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of theSchistosoma mansoniegg-induced granulomatous response are areas of active investigation. Some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::859d155cd9362f087f2b0382349d9d6a
https://doi.org/10.1101/2020.09.29.318105
https://doi.org/10.1101/2020.09.29.318105
SUMMARY Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis releasing mycobacteria into the extracellular environment where they can grow unrestricted. In zebrafish infected with Mycobacterium marinum, a close r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60c795fa0e83a9befee84a14b0525e79
https://doi.org/10.1101/511436
https://doi.org/10.1101/511436