Perinatal derivatives application: Identifying possibilities for clinical use

Autor: Florelle Gindraux, Nicola Hofmann, Marta Agudo-Barriuso, Mariastefania Antica, Pedro Silva Couto, Marie Dubus, Serhiy Forostyak, Lenart Girandon, Roberto Gramignoli, Marcin Jurga, Sergio Liarte, Ruta Navakauskiene, Volodymyr Shablii, Xavier Lafarge, Francisco J. Nicolás

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Perinatal derivatives are drawing growing interest among the scientific community as an unrestricted source of multipotent stromal cells, stem cells, cellular soluble mediators, and biological matrices. They are useful for the treatment of diseases t

Externí odkaz: https://doaj.org/article/67dbbb4963b64539abd7856c1101ad5e

Expert Consideration on Regulatory Aspects for Perinatal Derivatives in Clinical Settings

Autor: Nicola Hofmann, Xavier Lafarge, Mariastefania Antica, Nicolas Ferry, Lenart Girandon, Roberto Gramignoli, Marcin Jurga, Halima Kerdjoudj, Ruta Navakauskiene, Jessica Schiavi, Volodymyr Shablii, Francisco J Nicolás, Florelle Gindraux

Publikováno v: Stem Cells Translational Medicine

Perinatal derivatives (PnD) are drawing growing interest among the scientific community as an unrestricted source of multipotent stem cells, secretome, and biological matrices. They are useful for the treatment of diseases that currently have limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d86bacd0fa81d5acb5abee0aea6a66
http://fulir.irb.hr/7949/

Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses

Autor: Sergio Liarte, Ángel Bernabé-García, Francisco J. Nicolás

Publikováno v: Cells, Vol 9, Iss 1, p 255 (2020)

Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-β (TFG-β). Although the etiologies o

Externí odkaz: https://doaj.org/article/7f16cf07ad9c4e9291fd17f54f7e2250

The FDA-Approved Antiviral Raltegravir Inhibits Fascin1-Dependent Invasion of Colorectal Tumor Cells In Vitro and In Vivo

Autor: Ángel Bernabé-García, María Luisa Cayuela-Fuentes, Manuel Bernabé-García, Pablo Conesa-Zamora, Irene Luque, Horacio Pérez-Sánchez, Begoña Alburquerque-González, Francisco J. Nicolás, Javier Ruiz-Sanz, Silvia Montoro-García, Leonardo Gonnelli, Enrico Luchinat, Lucia Banci, Jorge Peña-García, Fernando F López-Calderón

Publikováno v: Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Cancers, Vol 13, Iss 861, p 861 (2021)
Cancers
Volume 13
Issue 4

Simple Summary: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. Serrated adenocarcinoma (SAC) has been recently recognized by the WHO as a histological CRC with bad prognosis. Consistent with previous evidence,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e89816bc00310824e9253ea01139a7d
https://pubmed.ncbi.nlm.nih.gov/33670655

Novel anti-invasive properties of a Fascin1 inhibitor on colorectal cancer cells

Autor: Francisco J. Nicolás, Horacio Pérez-Sánchez, María L. Cayuela, Priscila Campioni Rodrigues, Irene Luque, Helena den-Haan, Tuula Salo, Begoña Alburquerque-González, Silvia Montoro-García, Ángel Bernabé-García, Pablo Conesa-Zamora, Manuel Bernabé-García

Tumor invasion and metastasis involve processes in which actin cytoskeleton rearrangement induced by Fascin1 plays a crucial role. Indeed, Fascin1 has been found overexpressed in tumors with worse prognosis. Migrastatin and its analogues target Fasci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07761ad32d917d5e155c875dc8d2e9ec
http://hdl.handle.net/10138/325423