Zobrazeno 1 - 10
of 1 536
pro vyhledávání: '"Francisco J, Blanco"'
Autor:
Alejandro Durán-Sotuela, Jorge Vázquez-García, Sara Relaño-Fernández, Vanesa Balboa-Barreiro, Juan Fernández-Tajes, Francisco J. Blanco, Ignacio Rego-Pérez
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundIn the context of the cytokine storm the takes place in severe COVID-19 patients, the Interleukin 6 (IL6) pathway emerges as one of the key pathways involved in the pathogenesis of this hyperinflammatory state. The strategy of blocking the
Externí odkaz:
https://doaj.org/article/73e55356c705455a8df2e1540d8ca9f8
Autor:
Sietse E.S. Terpstra, Lotte A. van de Stadt, Francis Berenbaum, Francisco J. Blanco, Ida K. Haugen, Simon C. Mastbergen, Harrie Weinans, Mylène P. Jansen, Frits R. Rosendaal, Margreet Kloppenburg
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 3, Pp 100487- (2024)
Objective: To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA. Methods: We used baseline and two-year follow-up data from the IMI-APP
Externí odkaz:
https://doaj.org/article/0e925a2b6d4f48e28354a355f3ce3e28
Autor:
Alvaro Macias‐Diaz, Jose J. Lopez, Maria Bravo, Isaac Jardín, Waldo Luis Garcia‐Jimenez, Francisco J. Blanco‐Blanco, Rosario Cerrato, Juan A. Rosado
Publikováno v:
Molecular Oncology, Vol 18, Iss 5, Pp 1123-1142 (2024)
Store‐operated Ca2+ entry (SOCE) is a major mechanism for Ca2+ influx in colorectal cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca2+ stores, is mediated by the endoplasmic reticulum Ca2+ sensors of the st
Externí odkaz:
https://doaj.org/article/179a8bffce7e472f9c68aed715e7a97e
Autor:
Maite Silva-Díaz, Sonia Pértega-Díaz, Vanesa Balboa-Barreiro, Carlos M. Tilve-Álvarez, Ana Raga-Sivira, Ignacio Rego-Pérez, Francisco J. Blanco, Natividad Oreiro
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthrit
Externí odkaz:
https://doaj.org/article/220acdcf45f74a1d977a80ceccbac355
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1148 (2024)
Nutritional epigenomics is exceptionally important because it describes the complex interactions among food compounds and epigenome modifications. Phytonutrients or bioactive compounds, which are secondary metabolites of plants, can protect against o
Externí odkaz:
https://doaj.org/article/8c6232e4b34b4293938b81ac1781c222
Autor:
Andrea Dalmao-Fernández, Tamara Hermida-Gómez, Uxia Nogueira-Recalde, Ignacio Rego-Pérez, Francisco J. Blanco-Garcia, Mercedes Fernández-Moreno
Publikováno v:
Cells, Vol 13, Iss 11, p 976 (2024)
Authors have demonstrated that apoptosis activation is a pathway related to cartilage degradation characteristics of the OA process. Autophagy is an adaptive response to protect cells from various environmental changes, and defects in autophagy are l
Externí odkaz:
https://doaj.org/article/2e366a3d4f1a4af881a11ff6f50791b6
Autor:
Rodrigo Lázaro‐Gorines, Patricia Pérez, Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L. Harwood, Alejandro Segura‐Tudela, Laura Rubio‐Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A. Adipietro, Dinendra L. Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D. MacKerell Jr, Laura Sanz, David J. Weber, Francisco J. Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy‐Ruiz, Inés G. Muñoz, Rafael Delgado, David Sancho, Juan García‐Arriaza, Luis Álvarez‐Vallina
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Administration of neutralizing antibodies (nAbs) has proved to be effective by providing immediate protection against SARS‐CoV‐2. However, dual strategies combining virus neutralization and immune response stimulation to enhance specific
Externí odkaz:
https://doaj.org/article/83ee823ecfc342e88a1c1efafa321622
Autor:
Rocío Paz-González, Aleksandra Turkiewicz, Neserin Ali, Cristina Ruiz-Romero, Francisco J. Blanco, Martin Englund, Patrik Önnerfjord
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 4, Pp 100417- (2023)
Objective: To gain new insight into the molecular changes of the meniscus by comparing the proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis (OA). Method: We obtained tissue plugs from lateral and medial menisc
Externí odkaz:
https://doaj.org/article/d2dbd4769bac418ca4969291b2e620a6
Autor:
Paweł Widera, Paco M.J. Welsing, Samuel O. Danso, Sjaak Peelen, Margreet Kloppenburg, Marieke Loef, Anne C. Marijnissen, Eefje M. van Helvoort, Francisco J. Blanco, Joana Magalhães, Francis Berenbaum, Ida K. Haugen, Anne-Christine Bay-Jensen, Ali Mobasheri, Christoph Ladel, John Loughlin, Floris P.J.G. Lafeber, Agnès Lalande, Jonathan Larkin, Harrie Weinans, Jaume Bacardit
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 4, Pp 100406- (2023)
Objectives: To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine learning results in patient selection enri
Externí odkaz:
https://doaj.org/article/55e22c14dfcd491ebe747a57d5aa24d7
Autor:
Laura Rubio-Pérez, Rodrigo Lázaro-Gorines, Seandean L. Harwood, Marta Compte, Rocío Navarro, Antonio Tapia-Galisteo, Jaume Bonet, Belén Blanco, Simon Lykkemark, Ángel Ramírez-Fernández, Mariola Ferreras-Gutiérrez, Carmen Domínguez-Alonso, Laura Díez-Alonso, Alejandro Segura-Tudela, Oana Hangiu, Ainhoa Erce-Llamazares, Francisco J. Blanco, Cruz Santos, José L. Rodríguez-Peralto, Laura Sanz, Luis Álvarez-Vallina
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTImmune checkpoint blockade (ICB) with antibodies has shown durable clinical responses in a wide range of cancer types, but the overall response rate is still limited. Other effective therapeutic modalities to increase the ICB response rates a
Externí odkaz:
https://doaj.org/article/87732fe8a8464638935a3dfe1b8c3ab0