Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Francisco González-Bobes"'
Autor:
John R. Coombs, Jason Zhu, Francisco González-Bobes, Sanjeewa Rupasinghe, Kishta Katipally, Boguslaw Mudryk, William P. Gallagher, Carlos A. Guerrero, Candice L. Joe
Publikováno v:
Organic Process Research & Development. 26:583-591
The cyclohexyl fragment 1 in BMS-986251 was synthesized starting from Hagemann’s ester 2 in 7 steps and 5 isolations. The route is highlighted by a dynamic kinetic resolution (DKR), a telescoped en...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17ea0653ff5238432d57a80b901be60b
https://doi.org/10.1021/acs.oprd.1c00339
https://doi.org/10.1021/acs.oprd.1c00339
Autor:
William P. Gallagher, Francisco González-Bobes, Carlos A. Guerrero, John R. Coombs, Eric M. Simmons
Publikováno v:
Organic Process Research & Development. 26:592-600
We have devised an asymmetric route to the tricyclic core 10 of BMS-986251. The six-step synthesis utilizes readily available starting materials, involves the one-step installation of the perfluoro...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f04ffb511e5b6a9e9fe69e0a9725a8f
https://doi.org/10.1021/acs.oprd.1c00338
https://doi.org/10.1021/acs.oprd.1c00338
Autor:
Chris Sfouggatakis, Joerg Deerberg, Yu Fan, Charles Pathirana, Francisco González-Bobes, Yi Xiao, Bin Zheng, Michael Galella, Martin D. Eastgate, Nathaniel Kopp, Kay A Galindo, Thomas E. La Cruz
Publikováno v:
The Journal of Organic Chemistry. 87:1996-2011
BMS-813160 is a pharmaceutical entity currently in development at Bristol Myers Squibb. Its defining structural feature is a unique chiral all cis triamino cyclohexane core. Medicinal and process chemistry groups at BMS have previously published synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62ccbfe44744ff8b904609dd58251655
https://doi.org/10.1021/acs.joc.1c01162
https://doi.org/10.1021/acs.joc.1c01162
Autor:
Arun Vinodini, Saravanan Murugan, William P. Gallagher, Sankar Kuppusamy, Rajappa Vaidyanathan, Martin D. Eastgate, Kishore Ghanta, Sivasankar Bondigela, Aravind S. Gangu, Abhishek Shrikant, Shunmugaraj Sathasivam, Srinivas Kalidindi, Vijaykumar Shekarappa, Francisco González-Bobes, Moorthy Kandasamy, Nathaniel Kopp, Ravikumar Ramachandran
Publikováno v:
Organic Process Research & Development. 25:1556-1572
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d21860e3ebf0d8dd4438293818df38f
https://doi.org/10.1021/acs.oprd.1c00125
https://doi.org/10.1021/acs.oprd.1c00125
Autor:
John R. Coombs, Francisco González-Bobes, Boguslaw Mudryk, Arun Vinodini, Sankar Kuppusamy, Candice L. Joe, Senthil Palani, Muthukrishnan Ponnusamy, Vedhachalam Nagappan, Rajappa Vaidyanathan, William P. Gallagher, Aravind S. Gangu, Martin D. Eastgate, Sanjeewa Rupasinghe, Alla Venu, Nathaniel Kopp, Srinivas Kalidindi, Shankar Tendulkar
Publikováno v:
Organic Process Research & Development. 25:1547-1555
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5d45a55c301e242d68690ce145b08c
https://doi.org/10.1021/acs.oprd.1c00124
https://doi.org/10.1021/acs.oprd.1c00124
Autor:
John Hynes, Antonio Ramirez, John R. Coombs, Jade McDaniel, David Marcoux, Francisco González-Bobes, T. G. Murali Dhar, Amy A. Sarjeant, Arthur Han, Qing Shi, Christopher A. Farley, William P. Gallagher, Bhupinder Sandhu
Publikováno v:
Organic Letters. 23:60-65
The use of the unprecedented annulating reagents methyl N-(tert-butylsulfinyl)-4-chlorobutanimidate and methyl N-(tert-butylsulfinyl)-5-bromopentanimidate enables the diastereoselective preparation of 5- and 6-membered carbocycles bearing three conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74155f755af11fec471be78e17587fdd
https://doi.org/10.1021/acs.orglett.0c03695
https://doi.org/10.1021/acs.orglett.0c03695
Autor:
Debottam Dasgupta, Siva Sankar Bondigela, Arun Vinodini, Srinivas Kalidindi, Selin Aytar, Rajappa Vaidyanathan, Satish Korapati, Francisco González-Bobes, Prantik Maity, Aravind S. Gangu, Alla Venu, William P. Gallagher, Sri Krishna Nimmagadda, Noormohamed Abdul Malik
Publikováno v:
Organic Process Research & Development. 24:1141-1148
We describe the development and scale-up of a nickel-catalyzed reductive cross-electrophile coupling reaction between a substituted 2-chloropyridine and ethyl 3-chloropropanoate using manganese dus...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca6ee2e61a65e8ccbb306ffbca2dbfc
https://doi.org/10.1021/acs.oprd.0c00134
https://doi.org/10.1021/acs.oprd.0c00134
Autor:
Thomas E, La Cruz, Francisco, González-Bobes, Martin D, Eastgate, Chris, Sfouggatakis, Bin, Zheng, Nathaniel, Kopp, Yi, Xiao, Yu, Fan, Kay A, Galindo, Charles, Pathirana, Michael A, Galella, Joerg, Deerberg
Publikováno v:
The Journal of organic chemistry. 87(4)
BMS-813160 is a pharmaceutical entity currently in development at Bristol Myers Squibb. Its defining structural feature is a unique chiral all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47a414e30ef1bfb7dd80a291225ce565
https://pubmed.ncbi.nlm.nih.gov/34355895
https://pubmed.ncbi.nlm.nih.gov/34355895
Autor:
Francisco González-Bobes, John R. Coombs, Lucas W. Hernandez, William P. Gallagher, Carlos A. Guerrero
Publikováno v:
The Journal of organic chemistry. 86(15)
The use of sodium dithionite with perfluoroalkyl iodides under basic conditions facilitates the direct perfluoroalkylation of arenes with pendant benzylic electron-withdrawing groups. This occurs via attack of the arene on the electrophilic perfluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8ce6fba0f803e4c7dc82e575aeb034
https://pubmed.ncbi.nlm.nih.gov/34286987
https://pubmed.ncbi.nlm.nih.gov/34286987
Autor:
Yichen Tan, Yu Fan, Matthew R. Hickey, Michael A. Schmidt, Christopher Wilbert, Darryl D. Dixon, Vidya Iyer, Fanfair Dayne Dustan, Benjamin M. Cohen, Matthew W. Haley, Jason M. Stevens, Miao Yu, Kenneth J. Fraunhoffer, Andrew W. Glace, Adam Joseph Freitag, Kathryn Camacho, Francisco González-Bobes, Michael S. Bultman, Victor W. Rosso, Jeanne Ho, Ian S. Young, Albert J. DelMonte, Prantik Maity, Manjunath Gujjar, Gregory L. Beutner, Sunil S. Patel
Publikováno v:
Organic Process Research & Development. 23:2482-2498
The process development and the kilogram-scale synthesis of linrodostat (BMS-986205, 1) are described. The synthesis features several highly efficient telescoped processes and the use of Evans auxi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18fc98f98d4ade5101f6ab9c17d13eda
https://doi.org/10.1021/acs.oprd.9b00359
https://doi.org/10.1021/acs.oprd.9b00359