Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Francisco Garcia-Canovas"'
Autor:
Pablo Garcia-Molina, Francisco Garcia-Molina, Jose Antonio Teruel-Puche, Jose Neptuno Rodriguez-Lopez, Francisco Garcia-Canovas, Jose Luis Muñoz-Muñoz
Publikováno v:
Molecules, Vol 27, Iss 10, p 3141 (2022)
Tyrosinase is the enzyme involved in melanization and is also responsible for the browning of fruits and vegetables. Control of its activity can be carried out using inhibitors, which is interesting in terms of quantitatively understanding the action
Externí odkaz:
https://doaj.org/article/b3196ce046834d57aa90daae9aea5cb5
Autor:
Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Jose Berna, José Neptuno Rodriguez-Lopez, Jose Tudela, Francisco Garcia-Canovas
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177330 (2017)
The known derivatives from hydroquinone, α and β-arbutin, are used as depigmenting agents. In this work, we demonstrate that the oxy form of tyrosinase (oxytyrosinase) hydroxylates α and β-arbutin in ortho position of the phenolic hydroxyl group,
Externí odkaz:
https://doaj.org/article/e11ec7be1caf457bbb159054e578dd9c
Autor:
Antonio Garcia-Jimenez, Jose Antonio Teruel-Puche, Pedro Antonio Garcia-Ruiz, Adrian Saura-Sanmartin, Jose Berna, Francisco Garcia-Canovas, José Neptuno Rodriguez-Lopez
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187845 (2017)
Deoxyarbutin, a potent inhibitor of tyrosinase, could act as substrate of the enzyme. Oxytyrosinase is able to hydroxylate deoxyarbutin and finishes the catalytic cycle by oxidizing the formed o-diphenol to quinone, while the enzyme becomes deoxytyro
Externí odkaz:
https://doaj.org/article/4755ebd5057f47cf930552c565b3b6ca
Autor:
Samaneh Zolghadri, Mohammad Beygi, Tasneem F. Mohammad, Mahdi Alijanianzadeh, Thanigaimalai Pillaiyar, Pablo Garcia-Molina, Francisco Garcia-Canovas, Jose Munoz-Munoz, Ali Akbar Saboury
Publikováno v:
Biochemical Pharmacology. 212:115574
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b60df61df2857a2356d935deae2b7cee
https://doi.org/10.1016/j.bcp.2023.115574
https://doi.org/10.1016/j.bcp.2023.115574
Autor:
María F. Montenegro, José A. Teruel, Pablo García-Molina, José Tudela, José Neptuno Rodríguez-López, Francisco García-Cánovas, Francisco García-Molina
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6891 (2024)
Phenolic compounds with a position ortho to the free phenolic hydroxyl group occupied can be tyrosinase substrates. However, ortho-substituted compounds are usually described as inhibitors. The mechanism of action of tyrosinase on monophenols is comp
Externí odkaz:
https://doaj.org/article/bfb4d5d7ab2f4f089a25022cab32ffd6
Autor:
Antonio, Garcia-Jimenez, Jose Antonio, Teruel-Puche, Carmen Vanessa, Ortiz-Ruiz, Jose, Berna, Jose, Tudela, Francisco, Garcia-Canovas
Publikováno v:
IUBMB life. 68(8)
4-n-Butylresorcinol (BR) is considered the most potent inhibitor of tyrosinase, which is why it is used in cosmetics as a depigmenting agent. However, this work demonstrates that BR is a substrate of this enzyme. The Em (met-tyrosinase) form is not a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25e9cd17c79a3542a010dc75b84acaf9
https://pubmed.ncbi.nlm.nih.gov/27342394
https://pubmed.ncbi.nlm.nih.gov/27342394
Autor:
Carmen Vanessa, Ortiz-Ruiz, Miguel Angel, Maria-Solano, Maria Del Mar, Garcia-Molina, Ramon, Varon, Jose, Tudela, Virginia, Tomas, Francisco, Garcia-Canovas
Publikováno v:
IUBMB life. 67(10)
The development of effective tyrosinase inhibitors has become increasingly important in the cosmetic, medicinal, and agricultural industries for application as antibrowning and depigmenting agents. The kinetic mechanisms of action of tyrosinase on mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4db426c9af2ab780aaf89eb41de3b7b
https://pubmed.ncbi.nlm.nih.gov/26399372
https://pubmed.ncbi.nlm.nih.gov/26399372
Autor:
Carmen Vanessa, Ortiz-Ruiz, Manuel, Ballesta de Los Santos, Jose, Berna, Jose, Fenoll, Pedro Antonio, Garcia-Ruiz, Jose, Tudela, Francisco, Garcia-Canovas
Publikováno v:
IUBMB life. 67(11)
Oxyresveratrol is a stilbenoid described as a powerful inhibitor of tyrosinase and proposed as skin-whitening and anti-browning agent. However, the enzyme is capable of acting on it, considering it as a substrate, as it has been proved in the case of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d6f49db24be59d08ea416edfa615f79
https://pubmed.ncbi.nlm.nih.gov/26450473
https://pubmed.ncbi.nlm.nih.gov/26450473
Autor:
EDELMIRA VALERO, Manuela García Moreno, Ramón Varón Castellanos, Francisco García Sevilla, Francisco Garcia-Molina, María Llanos Amo Saus, Francisco Garcia-Canovas
Publikováno v:
Journal of Mathematical Chemistry. 38:67-88
To date, the classification as activator or inhibitor of a modifier involved in an enzyme catalysed reaction is established according to its kinetic behaviour at the steady state. Inhibitors and activators are defined as modifiers which decrease or i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088206094309cc7120123a6847069498
https://doi.org/10.1007/s10910-005-4530-9
https://doi.org/10.1007/s10910-005-4530-9
Autor:
Maria, del Mar Garcia-Molina, Jose Luis, Muñoz-Muñoz, Jose, Berna, Pedro Antonio, García-Ruiz, Jose Neptuno, Rodriguez-Lopez, Francisco, Garcia-Canovas
Publikováno v:
IUBMB life. 66(2)
Hydroxyhydroquinone (HHQ) was characterized kinetically as a tyrosinase substrate. A kinetic mechanism is proposed, in which HHQ is considered as a monophenol or as an o-diphenol, depending on the part of the molecule that interacts with the enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f6a3153ba2f50d8b7688a8187c6a90b
https://pubmed.ncbi.nlm.nih.gov/24578277
https://pubmed.ncbi.nlm.nih.gov/24578277