Epitranscriptomic regulation of HIV-1 full-length RNA packaging

Autor: Camila Pereira-Montecinos, Daniela Toro-Ascuy, Catarina Ananías-Sáez, Aracelly Gaete-Argel, Cecilia Rojas-Fuentes, Sebastián Riquelme-Barrios, Bárbara Rojas-Araya, Francisco García-de-Gracia, Paulina Aguilera-Cortés, Jonás Chnaiderman, Mónica L Acevedo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo

Publikováno v: Nucleic Acids Research. 50:2302-2318

During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA. However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules that will be packaged into nascent virions remain poorly understood. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fface9b90923818b22eafac1308b5798
https://doi.org/10.1093/nar/gkac062

CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev

Autor: Jonás Chnaiderman, Daniela Toro-Ascuy, Sebastián Riquelme-Barrios, Cecilia Rojas-Fuentes, Fernando Valiente-Echeverría, Francisco García-de-Gracia, Ricardo Soto-Rifo, Paulina Aguilera, Camila Pereira-Montecinos, Aarón Oyarzún-Arrau, Mónica Acevedo, Bárbara Rojas-Araya, Aracelly Gaete-Argel

Publikováno v: RNA Biol

Translation initiation of the human immunodeficiency virus type-1 (HIV-1) full-length RNA has been shown to occur through cap-dependent and IRES-driven mechanisms. Previous studies suggested that the nuclear cap-binding complex (CBC) rather than eIF4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad3952e7a6e924fbad0124e98b489d9
https://europepmc.org/articles/PMC8078705/

A Rev-CBP80-eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA

Autor: Aracelly Gaete-Argel, Cecilia Rojas-Fuentes, Ricardo Soto-Rifo, Camila Pereira-Montecinos, Daniela Toro-Ascuy, Fernando Valiente-Echeverría, Bárbara Rojas-Araya, Théophile Ohlmann, Francisco García-de-Gracia

Publikováno v: Nucleic Acids Research

Gag synthesis from the full-length unspliced mRNA is critical for the production of the viral progeny during human immunodeficiency virus type-1 (HIV-1) replication. While most spliced mRNAs follow the canonical gene expression pathway in which the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfac5bb4e17e3e723eb472bed2dcc3f3
https://doi.org/10.1101/313312

DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA through its N-terminal domain

Autor: Théophile Ohlmann, Alessandra Dellarossa, Alvaro Fröhlich, Fernando Valiente-Echeverría, Yara Prades-Pérez, Andrea Garcés-Alday, Francisco García-de-Gracia, Bárbara Rojas-Araya, Paulina S. Rubilar, Daniela Toro-Ascuy, Camila Pereira-Montecinos, Ricardo Soto-Rifo

Publikováno v: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2016, 1859 (5), pp.719-730. ⟨10.1016/j.bbagrm.2016.03.009⟩
BBA-Biochimica et Biophysica Acta, 2016, 1859 (5), pp.719-730. ⟨10.1016/j.bbagrm.2016.03.009⟩

International audience; DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel therapies aimed to overcome viral resistance. Previous studies have shown that DDX3 promotes nuclear export and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feeac3c3e210f09964fa16ff315c199d
https://pubmed.ncbi.nlm.nih.gov/27012366