Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Francisco G, Scholl"'
Autor:
Francisco Arias-Aragón, Enriqueta Tristán-Clavijo, Irene Martínez-Gallego, Estefanía Robles-Lanuza, Heriberto Coatl-Cuaya, Celia Martín-Cuevas, Ana C. Sánchez-Hidalgo, Antonio Rodríguez-Moreno, Amalia Martinez-Mir, Francisco G. Scholl
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106868- (2023)
Summary: Alzheimer’s disease (AD) is characterized by memory impairments and age-dependent synapse loss. Experimental and clinical studies have shown decreased expression of the glutamatergic protein Neuroligin-1 (Nlgn1) in AD. However, the consequ
Externí odkaz:
https://doaj.org/article/5233b3de08fc4b01a50dadad8bc24dfc
Autor:
Maria I. Alvarez-Vergara, Alicia E. Rosales-Nieves, Rosana March-Diaz, Guiomar Rodriguez-Perinan, Nieves Lara-Ureña, Clara Ortega-de San Luis, Manuel A. Sanchez-Garcia, Miguel Martin-Bornez, Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Beatriz Fernandez-Gomez, Miguel A. Marchena, Andrea S. Bullones-Bolanos, Jose C. Davila, Rocio Gonzalez-Martinez, Jose L. Trillo-Contreras, Ana C. Sanchez-Hidalgo, Raquel del Toro, Francisco G. Scholl, Eloisa Herrera, Martin Trepel, Jakob Körbelin, Luis M. Escudero, Javier Villadiego, Miriam Echevarria, Fernando de Castro, Antonia Gutierrez, Alberto Rabano, Javier Vitorica, Alberto Pascual
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Aß are extracellular deposits relevant in Alzheimer’s disease (AD). This study shows that Aß plaques are hubs of endothelial disassembly that induce non-productive angiogenesis. This process is aided by the microglia and unchained by reduced pres
Externí odkaz:
https://doaj.org/article/65297e3308ba45ef8cbc879a7f19dfe0
Autor:
Alvaro O. Ardiles, Andreas M. Grabrucker, Francisco G. Scholl, Gabby Rudenko, Tiziana Borsello
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Externí odkaz:
https://doaj.org/article/dd65ad9c042a4a048660d738eb4e5c74
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 338-346 (2014)
Autism spectrum disorders (ASDs) comprise a group of clinical phenotypes characterized by repetitive behavior and social and communication deficits. Autism is generally viewed as a neurodevelopmental disorder where insults during embryonic or early p
Externí odkaz:
https://doaj.org/article/829b19c786be4e54b31383bef3a41788
Autor:
Rafael J. Camacho-Garcia, Mª. Inmaculada Planelles, Mar Margalef, Maria L. Pecero, Rafael Martínez-Leal, Francisco Aguilera, Elisabet Vilella, Amalia Martinez-Mir, Francisco G. Scholl
Publikováno v:
Neurobiology of Disease, Vol 47, Iss 1, Pp 135-143 (2012)
The identification of mutations in genes encoding proteins of the synaptic neurexin–neuroligin pathway in different neurodevelopmental disorders, including autism and mental retardation, has suggested the presence of a shared underlying mechanism.
Externí odkaz:
https://doaj.org/article/730507e8eb704a70a5e757f9093d8352
Autor:
José Luis Trillo-Contreras, Pedro Gómez-Gálvez, Luis M. Escudero, Nieves Lara-Ureña, Andrea S. Bullones-Bolanos, Javier Vitorica, Miriam Echevarría, Rosana March-Díaz, Miguel Marchena, Jose Carlos Davila, Ana C. Sanchez-Hidalgo, Eloisa Herrera, Fernando de Castro, Jakob Körbelin, Antonia Gutierrez, Rocio González-Martínez, Alicia E. Rosales-Nieves, Raquel del Toro, Clara Ortega-de San Luis, Maria I. Alvarez-Vergara, Alberto Pascual, Pablo Vicente-Munuera, Manuel A. Sanchez-Garcia, Guiomar Rodriguez-Perinan, Martin Trepel, Francisco G. Scholl, Alberto Rábano, Javier Villadiego, Miguel Martin-Bornez, Beatriz Fernández-Gómez
Publikováno v:
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla
The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa049ed47a103e3d3ff4480d727c21b5
Autor:
Francisco Arias-Aragón, Francisco G. Scholl, M Teresa Romero-Barragán, Amalia Martinez-Mir, Celia Martín-Cuevas, Ana C. Sánchez-Hidalgo, José M. Delgado-García
Publikováno v:
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
Presenilins (PS) form the active subunit of the gamma-secretase complex, which mediates the proteolytic clearance of a broad variety of type-I plasma membrane proteins. Loss-of-function mutations in PSEN1/2 genes are the leading cause of familial Alz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3316d02386a8949c29d1136f3321cd66
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19430 (2011)
Neurexins are a large family of neuronal plasma membrane proteins, which function as trans-synaptic receptors during synaptic differentiation. The binding of presynaptic neurexins to postsynaptic partners, such as neuroligins, has been proposed to pa
Externí odkaz:
https://doaj.org/article/ceb55d1f53d34f9496383617cd425375
Autor:
Amalia Martinez-Mir, Miguel Lucas, Gemma Iglesias, Alfons Macaya, Antonio Castellano, Francisco G. Scholl, Enriqueta Tristán-Clavijo, Ana M. Rojas
Publikováno v:
Movement Disorders. 31:1743-1748
Background Episodic ataxia type 1 is a rare autosomal dominant neurological disorder caused by mutations in the KCNA1 gene that encodes the α subunit of voltage-gated potassium channel Kv1.1. The functional consequences of identified mutations on ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b0b196f7bc9e188b20597eba259bdfb
https://doi.org/10.1002/mds.26737
https://doi.org/10.1002/mds.26737
Autor:
Eftichia Duketis, Amaia Hervás, Giovanni Malerba, Thomas Bourgeron, Richard Delorme, Barbara Franke, Elisabetta Trabetti, Rafaela Caballero-Andaluz, Marion Benabou, Bru Cormand, Francisco G. Scholl, Christine M. Freitag, Nanda Rommelse, Afsheen Yousaf, Amalia Martinez-Mir, Elena Bacchelli, Agatino Battaglia, Marta Ribasés, Claudio Toma, Bàrbara Torrico, Elena Maestrini, Jan K. Buitelaar, Andreas G. Chiocchetti
Publikováno v:
Autism Research. 10:202-211
Common variants contribute significantly to the genetics of autism spectrum disorder (ASD), although the identification of individual risk polymorphisms remains still elusive due to their small effect sizes and limited sample sizes available for asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18c5ca1b178b4bbe7411b09c73a18290
https://doi.org/10.1002/aur.1662
https://doi.org/10.1002/aur.1662