Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Francisco Fernandez-Belda"'
Autor:
Antonio Lax, Fernando Soler, Mari C. Asensio-López, Jesús Sánchez-Más, Francisco Fernandez-Belda, Domingo A. Pascual-Figal
Publikováno v:
Archives of Biochemistry and Biophysics. 594:26-36
In atrial-derived HL-1 cells, ryanodine receptor and Na(+)/Ca(2+)-exchanger were altered early by 5 μM doxorubicin. The observed effects were an increase of cytosolic Ca(2+) at rest, ensuing ryanodine receptor phosphorylation, and the slowing of Ca(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97846dcd12bafc59c29fafc0fd2f9ea6
https://doi.org/10.1016/j.abb.2016.02.021
https://doi.org/10.1016/j.abb.2016.02.021
Publikováno v:
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
Las especies reactivas de oxígeno (ROS) actúan como regulador intracelular cuando se generan de forma controlada en puntos concretos de la célula. Modifican la función de proteínas mediante la oxidación reversible de cisteínas. Hay quinasas y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bedda55c4ca73840067201384ecec9
http://hdl.handle.net/10201/101761
http://hdl.handle.net/10201/101761
Publikováno v:
European Journal of Pharmacology. 765:429-436
Cyclic nucleotide phosphodiesterase (PDE)3 and PDE4 provide the major PDE activity in cardiac myocytes and shape β1-adrenoceptor-dependent cardiac cAMP signaling but their role in regulating β2-adrenoceptor-mediated responses is less well known. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f176a314ee6742037bfeaafe38037b9f
https://doi.org/10.1016/j.ejphar.2015.09.001
https://doi.org/10.1016/j.ejphar.2015.09.001
Autor:
Antonio Lax, Fernando Soler, Domingo A. Pascual-Figal, Mari C. Asensio-López, Francisco Fernandez-Belda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172803 (2017)
PLoS ONE, Vol 12, Iss 2, p e0172803 (2017)
The primary cardiotoxic action of doxorubicin when used as antitumor drug is attributed to the generation of reactive oxygen species (ROS) therefore effective cardioprotection therapies are needed. In this sense, the antianginal drug nicorandil has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6f11e24b87978da3ca32a761f39692
http://europepmc.org/articles/PMC5330507
http://europepmc.org/articles/PMC5330507
Autor:
Christoph Handschin, Jesús Hernández-Cascales, Francisco Fernandez-Belda, Joaquín Pérez-Schindler, Teodomiro Fuente, Fernando Soler
Publikováno v:
Experimental Biology and Medicine. 240:1205-1213
The important regulator of cardiac function, cAMP, is hydrolyzed by different cyclic nucleotide phosphodiesterases (PDEs), whose expression and activity are not uniform throughout the heart. Of these enzymes, PDE2 shapes β1 adrenoceptor-dependent ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add296233dc1653ab235281b172dbef1
https://doi.org/10.1177/1535370214560969
https://doi.org/10.1177/1535370214560969
Publikováno v:
Journal of Bioenergetics and Biomembranes. 44:597-605
The use of a microsomal preparation from skeletal muscle revealed that both Ca(2+) transport and Ca(2+)-dependent ATP hydrolysis linked to Sarco-Endoplasmic Reticulum Ca(2+)-ATPase are inhibited by epigallocatechin-3-gallate (EGCG). A half-maximal ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba65dd4645a8da4804fa9d67d902d76
https://doi.org/10.1007/s10863-012-9462-z
https://doi.org/10.1007/s10863-012-9462-z
Autor:
Domingo A. Pascual-Figal, M. Carmen Asensio, Antonio Lax, Fernando Soler, Francisco Fernandez-Belda
Publikováno v:
Archives of Biochemistry and Biophysics. 512:175-182
Increase of resting Ca 2+ levels and amplitude of vasopressin-induced Ca 2+ transients were observed when cells in serum-free medium were exposed to 5 mM Ca 2+ for 2 h. Small effect on cell viability was also observed. A rapid cytotoxic effect was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7afeb74137e840a6cd54f671b8accc
https://doi.org/10.1016/j.abb.2011.05.019
https://doi.org/10.1016/j.abb.2011.05.019
Publikováno v:
Journal of Bioenergetics and Biomembranes. 41:369-377
The release of cytochrome c from mitochondria induced by 10 microM thapsigargin was linked to rapid loss of the mitochondrial membrane potential whereas that induced by 50 nM staurosporine was mediated by Bax activation and occurred in polarized mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc3f52774ec2fee3b560e9d34a6c8f8
https://doi.org/10.1007/s10863-009-9236-4
https://doi.org/10.1007/s10863-009-9236-4
Publikováno v:
Archives of Biochemistry and Biophysics. 478:36-42
The effect of palytoxin was studied in a microsomal fraction enriched in longitudinal tubules of the sarcoplasmic reticulum membrane. Half-maximal effect of palytoxin on Ca 2+ -ATPase activity yielded an apparent inhibition constant of approx. 0.4 μ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3476b089806733030bc99bb7767c08c
https://doi.org/10.1016/j.abb.2008.07.017
https://doi.org/10.1016/j.abb.2008.07.017
Publikováno v:
Archives of Biochemistry and Biophysics. 466:194-202
Experimental sarcoplasmic reticulum damage induced by 3 microM thapsigargin or 1 microg/ml tunicamycin provoked viability loss of the cell population in approximately 72 h. Release of cytochrome c from mitochondria was an early event and Bax transloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee21e1d38c7a27f42150ad8c3c716e0
https://doi.org/10.1016/j.abb.2007.06.022
https://doi.org/10.1016/j.abb.2007.06.022