Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Francisco Conejero Lara"'
Autor:
Daniel Polo-Megías, Mario Cano-Muñoz, Alberto G. Berruezo, Géraldine Laumond, Christiane Moog, Francisco Conejero-Lara
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15511 (2022)
Since the beginning of the COVID-19 pandemic, considerable efforts have been made to develop protective vaccines against SARS-CoV-2 infection. However, immunity tends to decline within a few months, and new virus variants are emerging with increased
Externí odkaz:
https://doaj.org/article/4122dbb4a8064edeaff01ac0cdf8b132
Autor:
Mario Cano-Muñoz, Julie Lucas, Li-Yun Lin, Samuele Cesaro, Christiane Moog, Francisco Conejero-Lara
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2794 (2022)
Inhibition of the HIV-1 fusion process constitutes a promising strategy to neutralize the virus at an early stage before it enters the cell. In this process, the envelope glycoprotein (Env) plays a central role by promoting membrane fusion. We previo
Externí odkaz:
https://doaj.org/article/3a798f8cf97c4f2897de49f0ae0b0b83
Autor:
Mario Cano-Muñoz, Daniel Polo-Megías, Ana Cámara-Artigas, José A. Gavira, María J. López-Rodríguez, Géraldine Laumond, Sylvie Schmidt, Julien Demiselle, Seiamak Bahram, Christiane Moog, Francisco Conejero-Lara
Publikováno v:
International Journal of Biological Macromolecules. 222:2467-2478
SARS-CoV-2 spike (S) protein mediates virus attachment to the cells and fusion between viral and cell membranes. Membrane fusion is driven by mutual interaction between the highly conserved heptad-repeat regions 1 and 2 (HR1 and HR2) of the S2 subuni
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6370 (2021)
The formation of fibrillar aggregates of the amyloid beta peptide (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). A clear understanding of the different aggregation steps leading to fibrils formation is a keystone in therape
Externí odkaz:
https://doaj.org/article/6203f8d386bc4e658e12dcc521ebce9a
Autor:
Mario Cano-Muñoz, Samuele Cesaro, Bertrand Morel, Julie Lucas, Christiane Moog, Francisco Conejero-Lara
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 566 (2021)
A promising strategy to neutralize HIV-1 is to target the gp41 spike subunit to block membrane fusion with the cell. We previously designed a series of single-chain proteins (named covNHR) that mimic the trimeric coiled-coil structure of the gp41 N-t
Externí odkaz:
https://doaj.org/article/754f2b1ff26f4685906317111bfd0fb0
Publikováno v:
International Journal of Biological Macromolecules. 192:90-99
During HIV-1 infection, the envelope glycoprotein subunit gp41 folds into a six-helix bundle structure (6HB) formed by the interaction between its N-terminal (NHR) and C-terminal (CHR) heptad-repeats, promoting viral and cell membranes fusion. A high
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4b294921afcf6c622b376bb783c7dae
https://doi.org/10.1007/978-1-0716-2597-2_2
https://doi.org/10.1007/978-1-0716-2597-2_2
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Amyloid aggregation is a hallmark in many neuropathologies and other diseases of tremendous impact. It is increasingly evident that neuronal death associated with Alzheimer's disease (AD) is mainly produced by oligomers of the amyloid-β (Aβ) peptid
Autor:
David Ruzafa, Yuriko S Hernandez-Gomez, Giovanni Bisello, Kerensa Broersen, Bertrand Morel, Francisco Conejero-Lara
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178576 (2017)
The biological function of α-Synuclein has been related to binding to lipids and membranes but these interactions can also mediate α-Synuclein aggregation, which is associated to Parkinson's disease and other neuropathologies. In brain tissue α-Sy
Externí odkaz:
https://doaj.org/article/003351aef5c240288343aff177f69d88
Autor:
Mayte Conejero-Muriel, Mari C. Mañas-Torres, Vaibhav Bhatia, Modesto T. López-López, María Arredondo-Amador, Francisco Conejero-Lara, Luis Álvarez de Cienfuegos, Mercedes González, Guillermo Escolano-Casado, Juan J. Díaz-Mochón, Rafael Contreras-Montoya, Jose A. Gavira, Fermín Sánchez de Medina, Olga Martínez-Augustin
Publikováno v:
ACS Applied Materials & Interfaces
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digibug. Repositorio Institucional de la Universidad de Granada
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digibug. Repositorio Institucional de la Universidad de Granada
[EN] Protein therapeutics have a major role in medicine in that they are used to treat diverse pathologies. Their three-dimensional structures not only offer higher specificity and lower toxicity than small organic compounds but also make them less s