Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Francisco Andres Peralta"'
Publikováno v:
Current Opinion in Pharmacology. 62:109-116
Ligand-gated ion channels (LGIC, also referred to as ionotropic receptors) are important transmembrane proteins that open to allow ions to flow across the membrane and locally modify the membrane potential in response to the binding of a ligand. For
Autor:
Francisco Andrés Peralta, Mélaine Balcon, Adeline Martz, Deniza Biljali, Federico Cevoli, Benoit Arnould, Antoine Taly, Thierry Chataigneau, Thomas Grutter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix,
Externí odkaz:
https://doaj.org/article/6e2b23ec63e6488caee682f240ae2c00
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10896 (2023)
Macropore formation and current facilitation are intriguing phenomena associated with ATP-gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that allow the passage of large molecules. The precise mechanisms underlying
Externí odkaz:
https://doaj.org/article/595d1290953c438d935e4a4116b16b75
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7288 (2021)
To ascertain the role of Zn(II) as an allosteric modulator on P2X4R, QM/MM molecular dynamic simulations were performed on the WT and two P2X4R mutants suggested by previous electrophysiological data to affect Zn(II) binding. The Gibbs free energy fo
Externí odkaz:
https://doaj.org/article/0c33163311424627844b36350afd0ff1
Autor:
Kate Dunning, Adeline Martz, Francisco Andrés Peralta, Federico Cevoli, Eric Boué-Grabot, Vincent Compan, Fanny Gautherat, Patrick Wolf, Thierry Chataigneau, Thomas Grutter
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6542 (2021)
P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the secretion of pro-inflammatory
Externí odkaz:
https://doaj.org/article/2e8a3d1c04d940949caf6a55bc5b72b0
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6940 (2020)
P2 × 4R is allosterically modulated by Zn(II), and despite the efforts to understand the mechanism, there is not a consensus proposal; C132 is a critical amino acid for the Zn(II) modulation, and this residue is located in the receptor head domain,
Externí odkaz:
https://doaj.org/article/730fa0913aef4fcea37fa6aac1633054
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 7, p 1059 (2016)
Zinc is an essential metal to life. This transition metal is a structural component of many proteins and is actively involved in the catalytic activity of cell enzymes. In either case, these zinc-containing proteins are metalloproteins. However, the
Externí odkaz:
https://doaj.org/article/4f90395a6f654a5e81fa37be6d865d8d