Zobrazeno 1 - 10 of 113 pro vyhledávání: '"Francisco, Morís"'
1
Akademický článek
High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma
Autor: Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Morís, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype of sporadic RCC tha
Externí odkaz: https://doaj.org/article/6b0458681f774fc788c19d8f3ed9c6d2
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2
Akademický článek
Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma
Autor: Aniello Federico, Tamara Steinfass, Lionel Larribère, Daniel Novak, Francisco Morís, Luz-Elena Núñez, Viktor Umansky, Jochen Utikal
Publikováno v: Molecular Therapy: Oncolytics, Vol 18, Iss , Pp 83-99 (2020)
Malignant melanoma is the most deadly skin cancer, associated with rising incidence and mortality rates. Most of the patients with melanoma, treated with current targeted therapies, develop a drug resistance, causing tumor relapse. The attainment of
Externí odkaz: https://doaj.org/article/99cbd00853c94ab28a3020afd9be2b9a
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3
Akademický článek
DESign of Sustainable One-Pot Chemoenzymatic Organic Transformations in Deep Eutectic Solvents for the Synthesis of 1,2-Disubstituted Aromatic Olefins
Autor: Nicolás Ríos-Lombardía, María Jesús Rodríguez-Álvarez, Francisco Morís, Robert Kourist, Natalia Comino, Fernando López-Gallego, Javier González-Sabín, Joaquín García-Álvarez
Publikováno v: Frontiers in Chemistry, Vol 8 (2020)
The self-assembly of styrene-type olefins into the corresponding stilbenes was conveniently performed in the Deep Eutectic Solvent (DES) mixture 1ChCl/2Gly under air and in the absence of hazardous organic co-solvents using a one-pot chemo-biocatalyt
Externí odkaz: https://doaj.org/article/f07ef966cc9f4e14a4a38a9237ac276c
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4
Akademický článek
The Mithralog EC-7072 Induces Chronic Lymphocytic Leukemia Cell Death by Targeting Tonic B-Cell Receptor Signaling
Autor: Seila Lorenzo-Herrero, Christian Sordo-Bahamonde, Gabriel Bretones, Ángel R. Payer, Ana P. González-Rodríguez, Esther González-García, Jhudit Pérez-Escuredo, Mónica Villa-Álvarez, Luz-Elena Núñez, Francisco Morís, Segundo Gonzalez, Alejandro López-Soto
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
B-cell receptor (BCR)-dependent signaling is central for leukemia B-cell homeostasis, as underscored by the promising clinical results obtained in patients with chronic lymphocytic leukemia (CLL) treated with novel agents targeting components of this
Externí odkaz: https://doaj.org/article/c9308b239ec243ad9b6907c1bcabb68e
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