Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Francisca Lottersberger"'
Publikováno v:
Vaccines, Vol 12, Iss 3, p 320 (2024)
Currently, vaccine development against different respiratory diseases is at its peak. It is of utmost importance to find suitajble adjuvants that can increase the potency of the vaccine candidates. This study aimed to determine the systemic and splen
Externí odkaz:
https://doaj.org/article/e2de43c4a66341a8928be0b43a01b1ae
Autor:
Logan R. Myler, Beatrice Toia, Cara K. Vaughan, Kaori Takai, Andreea M. Matei, Peng Wu, Tanya T. Paull, Titia de Lange, Francisca Lottersberger
Telomeres replicated by leading-strand synthesis lack the 3’ overhang required for telomere protection. Surprisingly, resection of these blunt telomere is initiated by the telomere-specific 5’ exonuclease Apollo rather than the Mre11-Rad50-Nbs1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df2ff2e907ad9853c700e0801ad6ebf
https://doi.org/10.1101/2023.03.06.531339
https://doi.org/10.1101/2023.03.06.531339
Background: At this time when vaccine development is at its peak against different respiratory diseases, it is of utmost importance to find suitable adjuvants that can increase the potency of the vaccine candidates. This study aims to find the system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5908d9911bcf8aea0ed309f063ad52e1
https://doi.org/10.21203/rs.3.rs-2210670/v1
https://doi.org/10.21203/rs.3.rs-2210670/v1
Autor:
Francisca Lottersberger, Daniel Durocher, Tatsuya Kibe, Kaori K. Takai, Titia de Lange, Hiroyuki Takai, Alessandro Bianchi, Michal Zimmermann, Zachary Mirman, Yi Gong
Publikováno v:
Nature
In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair—which requires a 3′ overhang—and classical non-homologous end joining, which can join unresected ends1,2. BRCA1-mutant cancers show minima
Publikováno v:
Cell. 163:880-893
Summary Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair remain unclear. Here, we use a telomere-based system to track
Autor:
Francisca Lottersberger, Giovanna Lucchini, Simonetta Piatti, Andrea Panza, Maria Pia Longhese
Publikováno v:
Genetics. 173:661-675
14-3-3 proteins are highly conserved polypeptides that participate in many biological processes by binding phosphorylated target proteins. The Saccharomyces cerevisiae BMH1 and BMH2 genes, whose concomitant deletion is lethal, encode two functionally
Autor:
Francisca Lottersberger, Titia de Lange, Michel C. Nussenzweig, Anne Bothmer, Davide F. Robbiani
Tumor suppressor p53-binding protein 1 (53BP1) regulates the repair of dysfunctional telomeres lacking the shelterin protein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here, by blocking 5′ resection by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7a00bd2367181b19db70c5c36df955
https://europepmc.org/articles/PMC3568336/
https://europepmc.org/articles/PMC3568336/
Publikováno v:
Science (New York, N.Y.). 339(6120)
Fixing Broken DNA Some physiological processes, such as immunoglobulin class switching and telomere attrition, result in double-stranded DNA breaks. The DNA damage repair protein, 53BP1, prevents nucleolytic processing of these breaks, but the protei
Publikováno v:
Molecular and cellular biology. 27(9)
The highly conserved 14-3-3 proteins participate in many biological processes in different eukaryotes. The BMH1 and BMH2 genes encode the two functionally redundant Saccharomyces cerevisiae 14-3-3 isoforms. In this work we provide evidence that defec