Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Francisca C. Gushiken"'
Autor:
Francisca C Gushiken, Han Hyojeong, Subhashree Pradhan, Kimberly W Langlois, Nawaf Alrehani, Miguel A Cruz, Rolando E Rumbaut, K Vinod Vijayan
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8304 (2009)
BACKGROUND:Hemostasis and thrombosis are regulated by agonist-induced activation of platelet integrin alpha(IIb)beta(3). Integrin activation, in turn is mediated by cellular signaling via protein kinases and protein phosphatases. Although the catalyt
Externí odkaz:
https://doaj.org/article/57f1b97b0ae54165a94560c3a3290c0b
Autor:
Doug Bolgiano, José A. López, Xiaoping Wu, Rolando E. Rumbaut, Jing-fei Dong, Breia J. Salsbery, K. Vinod Vijayan, Francisca C. Gushiken, Roberto Adachi, Zhou Zhou, Niloufar Aghakasiri, Naijie Jing
Publikováno v:
Circulation. 127:476-485
Background— Platelet hyperactivity induced by inflammation is a known risk factor for atherosclerosis and thrombosis, but its underlying mechanisms remain poorly understood. Methods and Results— The signal transducer and activator of transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d965b9f824f16a4e09fe4b30c4fc080f
https://doi.org/10.1161/circulationaha.112.132126
https://doi.org/10.1161/circulationaha.112.132126
Publikováno v:
Critical Care Medicine. 40:1-328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447a5fc11bba1583018caab68cabf942
https://doi.org/10.1097/01.ccm.0000424399.19903.8e
https://doi.org/10.1097/01.ccm.0000424399.19903.8e
Autor:
Subhashree Pradhan, Joel L. Moake, Tanvir Khatlani, Jing-fei Dong, K. V. Vijayan, Francisca C. Gushiken, Nancy A. Turner, Leticia Nolasco
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:1009-1018
Summary. Background: Secretion of Weibel–Palade body (WPB) contents is regulated, in part, by the phosphorylation of proteins that constitute the endothelial exocytotic machinery. In comparison to protein kinases, a role for protein phosphatases in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce2a1dc20f9dab57983ea8b6af71076
https://doi.org/10.1111/j.1538-7836.2009.03355.x
https://doi.org/10.1111/j.1538-7836.2009.03355.x
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:865-870
Summary. Background and Objectives: The complement system is a biochemical cascade composed of several plasma proteins that can interact with endothelial cells and blood cells, including platelets. In order to investigate the effect of the complement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05af231eecefcb3df7b7bd33947a221a
https://doi.org/10.1111/j.1538-7836.2009.03334.x
https://doi.org/10.1111/j.1538-7836.2009.03334.x
Autor:
K. Vinod Vijayan, Subhashree Pradhan, Yuandong Peng, Francisca C. Gushiken, Vimal Patel, Angela L. Bergeron, Yan Liu
Publikováno v:
Journal of Biological Chemistry. 283:12862-12869
Integrin αIIbβ3 activation is critical for platelet physiology and is controlled by signal transduction through kinases and phosphatases. Compared with kinases, a role for phosphatases in platelet integrin αIIbβ3 signaling is less understood. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb4046357d880ecb5833daee483b507a
https://doi.org/10.1074/jbc.m708804200
https://doi.org/10.1074/jbc.m708804200
Publikováno v:
Human Gene Therapy. 18:837-848
Thrombocytopenia is one of the complications for in vivo administration of adenovirus serotype 5 (Ad5) vectors after intravenous injection. In this paper, we investigated the mechanism of Ad5-induced thrombocytopenia and how these effects are attenua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9a6f05778e79edd5181da5847914e4
https://doi.org/10.1089/hum.2007.0051
https://doi.org/10.1089/hum.2007.0051
Publikováno v:
Thrombosis Research. 108:175-180
beta2-glycoprotein I is a phospholipid-binding protein of 326 amino acids and is found in plasma at a concentration of approximately 200 microg/ml. It has a sequence of positively charged amino acids located at the carboxy terminus that mediates anio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd532abb523fb2231e1bc4be9915d303
https://doi.org/10.1016/s0049-3848(02)00392-4
https://doi.org/10.1016/s0049-3848(02)00392-4
Autor:
Tanvir Khatlani, Subhashree Pradhan, Angela L. Bergeron, K. V. Vijayan, Qi Da, Francisca C. Gushiken, Kimberly W. Langlois, Rolando E. Rumbaut, J. D. Molkentin
Summary Background Calcium-dependent signaling mechanisms play a critical role in platelet activation. Unlike calcium-activated protease and kinase, the contribution of calcium-activated protein serine/threonine phosphatase in platelet activation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2195fcfe3fa560d1ec2fb4939b709a75
https://europepmc.org/articles/PMC4268338/
https://europepmc.org/articles/PMC4268338/
Publikováno v:
American Journal of Hematology. 65:160-165
β2-Glycoprotein I, an anionic phospholipid-binding 50-kDa plasma protein, circulates in the plasma at a concentration of 30–200 μg/ml. Its physiological role remains uncertain, but an important clue to this role is suggested by the finding that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4511727e196ac9362be7463ded6a21
https://doi.org/10.1002/1096-8652(200010)65:2<160::aid-ajh12>3.0.co
https://doi.org/10.1002/1096-8652(200010)65:2<160::aid-ajh12>3.0.co