Zobrazeno 1 - 10
of 270
pro vyhledávání: '"Francis Y. Lee"'
Publikováno v:
Cells, Vol 13, Iss 6, p 522 (2024)
Fracture callus formation is a dynamic stage of bone activity and repair with precise, spatially localized gene expression. Metastatic breast cancer impairs fracture healing by disrupting bone homeostasis and imparting an altered genomic profile. Pre
Externí odkaz:
https://doaj.org/article/a8a5afb55f1f4860917902f035cbcecd
Autor:
Hyuk-Kwon Kwon, Sean V. Cahill, Kristin E. Yu, Kareme D. Alder, Christopher M. Dussik, Jain Jeong, Jung Ho Back, Francis Y. Lee
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionDiabetes mellitus (DM) impairs fracture healing and is associated with susceptibility to infection, which further inhibits fracture healing. While intermittent parathyroid hormone (1-34) (iPTH) effectively improves fracture healing, it is
Externí odkaz:
https://doaj.org/article/1eb8782af7ba43ba83ccbf8651255737
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection
Autor:
Taiwo Samuel Agidigbi, Hyuk-Kwon Kwon, James R. Knight, Dejian Zhao, Francis Y. Lee, Irvin Oh
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionInfection in diabetic foot ulcers (DFUs) is one of the major complications associated with patients with diabetes. Staphylococcus aureus is the most common offending pathogen in patients with infected DFU. Previous studies have suggested
Externí odkaz:
https://doaj.org/article/1d0790a8ddcd40daa84e487e567c4597
Autor:
Jungho Back, Minh Nam Nguyen, Lu Li, Saelim Lee, Inkyu Lee, Fancheng Chen, Lauren Gillinov, Yeon-Ho Chung, Kareme D. Alder, Hyuk-Kwon Kwon, Kristin E. Yu, Christopher M. Dussik, Zichen Hao, Michael J. Flores, Yoseph Kim, Izuchukwu K. Ibe, Alana M. Munger, Sung Wook Seo, Francis Y. Lee
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation, thereby predisposing patients to pathological fracture and cancer growth. Alteration of osteob
Externí odkaz:
https://doaj.org/article/be04f427e4a7463ca43298e5ceafb353
Autor:
Hyuk-Kwon Kwon, Christopher M. Dussik, Sang-Hun Kim, Themis R. Kyriakides, Irvin Oh, Francis Y. Lee
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Bacterial infection within the synovial joint, commonly known as septic arthritis, remains a clinical challenge as it presents two concurrent therapeutic goals of reducing bacterial burden and preservation of articular cartilage from destructive host
Externí odkaz:
https://doaj.org/article/fe963741b8504a53bc24a0946915d9fb
Autor:
Joseph B. Kahan, MD, MPH, Christopher A. Schneble, MD, Ryan Applonie, DO, Allen Nicholson, MD, Ian Whittall, BA, Rachel Talley-Bruns, MD, Anna Jorgensen, MD, Nicole LaVette, APRN, Jay Moran, BS, J. Kristopher Ware, MD, Francis Y. Lee, MD, PhD, Theodore A. Blaine, MD
Publikováno v:
JSES Reviews, Reports, and Techniques, Vol 1, Iss 2, Pp 96-101 (2021)
Background: There is wide variability in surgical technique for biceps tenodesis. Prior biomechanical studies have demonstrated superior ultimate and fatigue strength with a Krakow-type locked loop when compared with simple suture and lasso-loop conf
Externí odkaz:
https://doaj.org/article/160fdd7955364da88208d84079c6df6f
Autor:
Hyuk-Kwon Kwon, Mahesh Chandra Patra, Hyeon-Jun Shin, Xiangai Gui, Asma Achek, Suresh Panneerselvam, Dong-Jin Kim, Suk-Jong Song, Riwon Hong, Kyoung Soo Kim, Yang Gyun Kim, Francis Y. Lee, Dae-Hyun Hahm, Sang Ho Lee, Sangdun Choi
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-19 (2019)
Inflammation: A decoy peptide treats arthritis and sepsis in mice A newly discovered peptide drug that disrupts signaling through a critical immune pathway could offer a new treatment for inflammatory diseases. Sangdun Choi from Ajou University in Su
Externí odkaz:
https://doaj.org/article/d6e0d5885d2f46d4af80b5803f5e237b
Autor:
Kristin E. Yu, Kareme D. Alder, Montana T. Morris, Alana M. Munger, Inkyu Lee, Sean V. Cahill, Hyuk-Kwon Kwon, JungHo Back, Francis Y. Lee
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 12 (2020)
Naringin is a naturally occurring flavonoid found in plants of the Citrus genus that has historically been used in traditional Chinese medical regimens for the treatment of osteoporosis. Naringin modulates signaling through numerous molecular pathway
Externí odkaz:
https://doaj.org/article/9293324847c344d4992a1f94ae7b1695
Publikováno v:
Journal of Functional Foods, Vol 35, Iss , Pp 458-465 (2017)
The anti-rheumatic efficacy of grape powder (GP) diet was evaluated in transgenic mice (TG) overexpressing human tumor necrosis factor (TNF), a model for rheumatoid arthritis (RA). After 4-weeks, TG mice fed on 10% of GP showed improvement with epiph
Externí odkaz:
https://doaj.org/article/af5bd5ce89e447998d0bb601e79c2308
Autor:
Hong Shen, Lifei Wang, Weiqi Chen, Krista Menard, Yang Hong, Yuan Tian, Samuel J. Bonacorsi, W. Griffith Humphreys, Francis Y. Lee, Jinping Gan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 460-467 (2016)
To assess targeting of an epothilone folate conjugate (BMS-753493) to the folate receptor (FR)-overexpressed tumor in mice bearing both FR+ and FR– tumors, a series of experiments were conducted by quantitative whole-body autoradiography (QWBA) and
Externí odkaz:
https://doaj.org/article/ebd2251cedc4474c92e66080f6b9bb62